A Safety, Efficacy and Pharmacokinetic Study of BTCT4465A (Mosunetuzumab) as a Single Agent and Combined With Atezolizumab in Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

713

Participants

Timeline

Start Date

September 15, 2015

Primary Completion Date

May 21, 2024

Study Completion Date

September 1, 2025

Conditions
Lymphocytic Leukemia, ChronicLymphoma, Non Hodgkin
Interventions
DRUG

BTCT4465A (Mosunetuzumab) IV

Participants with B-cell NHL and CLL will receive BTCT4465A (Mosunetuzumab) via IV infusion.

DRUG

Atezolizumab

Participants assigned to an atezolizumab combination group will receive atezolizumab 1200 mg administered as an IV infusion in combination with BTCT4465A (Mosunetuzumab).

DRUG

BTCT4465A (Mosunetuzumab) SC

Participants with B-cell NHL and CLL will receive BTCT4465A (Mosunetuzumab) via SC injection.

Trial Locations (35)

2010

St Vincent's Hospital Sydney, Darlinghurst

3065

St. Vincent's Hospital Melbourne, Fitzroy

3168

Monash Health Clinical Trial Pharmacy department, Clayton

4101

Icon Cancer Care South Brisbane, South Brisbane

4102

Princess Alexandra Hospital, Woolloongabba

5000

Royal Adelaide Hospital, Adelaide

6009

The Perth Blood Institute, Nedlands

7000

Royal Hobart Hospital, Hobart

10016

New York Uni Medical Center, New York

10604

Memorial Sloan Kettering Cancer Center at Westchester, Harrison

11725

Memorial Sloan Kettering Cancer Center - Commack, Commack

19103

University of Pennsylvania, Philadelphia

31008

Clínica Universidad de Navarra, Pamplona

37007

Complejo Asistencial Universitario de Salamanca, Salamanca

50931

Universitatsklinikum Koln, Cologne

55101

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz, Mainz

69120

Universitätsklinikum Heidelberg, Heidelberg

77030

MD Anderson Cancer Center, Houston

80218

Rocky Mountain Cancer Center, Denver

83177

Klinikum der Universität München, Campus Großhadern, München

93105

Sansum Medical Clinic, Inc., Santa Barbara

97477

Willamette Valley Cancer Insitute and Research Center, Springfield

280146

Hospital Universitario La Paz, Madrid

92093-0698

University of California San Diego Moores Cancer Center, La Jolla

06510

Yale University School Of Medicine, New Haven

07601

Hackensack University Medical Center, Hackensack

07645

Memorial Sloan Kettering Bergen, Montvale

M5G 2M9

Princess Margaret Hospital, Toronto

H3T 1E2

Jewish General Hospital, Montreal

03080

Seoul National University Hospital, Seoul

06351

Samsung Medical Center, Seoul

08035

Hospital Universitario Vall d Hebron, Barcelona

EC1A 7BE

Barts Cancer Institute, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

SM2 5PT

Royal Marsden Hospital;Institute of Cancer Research, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY