Nivolumab After Induction Treatment in Triple-negative Breast Cancer (TNBC) Patients

PHASE2UnknownINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

August 31, 2015

Primary Completion Date

December 31, 2023

Study Completion Date

August 31, 2025

Conditions
Breast Cancer
Interventions
DRUG

Nivolumab

nivolumab 3 mg/kg, every 2 weeks after induction treatment

RADIATION

Radiation therapy

20 Gy to metastatic lesion

DRUG

Low dose doxorubicin

15 mg flat dose, once weekly for 2 weeks

DRUG

Cyclophosphamide

metronomic schedule, 50 mg daily orally for 2 weeks

DRUG

Cisplatin

40 mg/m2, weekly for 2 weeks

Trial Locations (1)

1066 CX

Antoni van Leeuwenhoek, Amsterdam

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

The Netherlands Cancer Institute

OTHER