Safety And Efficacy Study Of Palbociclib Plus Cetuximab Versus Cetuximab To Treat Head And Neck Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

125

Participants

Timeline

Start Date

September 10, 2015

Primary Completion Date

July 19, 2018

Study Completion Date

September 7, 2022

Conditions
Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Interventions
DRUG

palbociclib

Palbociclib will be supplied as capsules containing 75 mg, 100 mg, or 125 mg equivalents of palbociclib free base. Administered with food on Day 1 to Day 21 followed by 7 days off treatment in a 28-day cycle.

DRUG

Cetuximab

Cetuximab injection for IV infusion will be provided in 100 mg/50 mL, single-use vials, and 200 mg/100 mL, single-use vials. In Japan, cetuximab will be provided in 100 mg/20 mL, single-use vials. Administered, 400 mg/m2 initial dose as a 120-minute IV infusion followed by 250 mg/m2 weekly infused over 60 minutes.

DRUG

Placebo

"Placebo for palbociclib will be indistinguishable from the palbociclib capsules and will be supplied as capsules matching in size and color the various palbociclib formulations.~Administered with food on Day 1 to Day 21 followed by 7 days off treatment in a 28-day cycle."

Trial Locations (71)

114

Tri-Service General Hospital, Taipei

407

Taichung Veterans General Hospital, Taichung

704

National Cheng Kung University Hospital Department of Pathology, Tainan City

4032

Debreceni Egyetem klinikai Koezpont Onkologiai Intezet, Debrecen

5000

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet,Onkologiai Kozpont, Szolnok

7623

Neuro CT Kft, Pécs

7624

Pecsi Tudomanyegyetem, Klinikai Kozpont, Laboratoriumi, Pécs

Pecsi Tudomanyegyetem, Klinikai Kozpont,, Pécs

11000

Institute for Oncology and Radiology of Serbia, Belgrade

Military Medical Academy, Belgrade

14080

Instituto Nacional de Cancerologia, Mexico City

21029

Podilskiy Regional Center of Oncology, Chemotherapy Department, Vinnytsia

28041

Hospital Universitario 12 de Octubre, Madrid

31008

Servicio de Oncologia, Pamplona

36200

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. ks. B. Markiewicza, Brzozów

37232

Henry Joyce Cancer Clinic, Nashville

40202

University Medical Center, lnc.:DBA University of Louisville Hospital, Louisville

40447

China Medical University Hospital, Taichung

45069

UC Health Physicians Office South, West Chester

45219

University of Cincinnati Investigational Pharmacy, Cincinnati

University of Cincinnati Medical Center, Cincinnati

49044

SI Dnipropetrovsk Medical Academy of MoH of Ukraine, Chair of Oncology and Medical Radiology, Dnipropetrovsk

49102

CI Dnipropetrovsk City Multifunctional Clinical Hospital #4 of Dnipropetrovsk Regional Council, Dnipropetrovsk

50048

"Communal Institution Krivorizhskiy Oncology Dispensary of Dnipropetrovsk Regional Council,", Kryvyi Rih

55905

Mayo Clinic, Rochester

58013

"Communal Institution Chernivtsi Regional clinical oncology dispensary,", Chernivtsy

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine, Siteman Cancer Center, St Louis

63129

Siteman Cancer Center - South County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center, City of Saint Peters

64460

Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey

68000

Cirugia y Ginecobstetricia de Oaxaca S.A de C.V Hospital Reforma, Oaxaca City

Oaxaca Site Management Organization S C, Oaxaca City

68020

Diaz San Juan Noe, Imagenologia Siglo XXI San Felipe, Oaxaca City

68120

Daniel Javier Mendez Lopez Imagen y Diagnostico Medico IDM, Oaxaca City

70154

National Cheng Kung University Hospital, Tainan City

73000

Communal Institution of Kherson Regional Council Kherson Regional Oncological Dispensary, Antonivka

76018

Regional Clinical Hospital, Department of microsurgery of otolaryngology organs, Ivano-Frankivsk

77520

Fakultni nemocnice Olomouc, Lekarna, Olomouc

80131

Istituto Nazionale Tumori Napoli, Napoli

83310

Narodny onkologicky ustav, Bratislava

92037

UC San Diego Medical Center - La Jolla (Thornton Hospital), La Jolla

92093

UC San Diego Moores Cancer Center, La Jolla

92103

UC San Diego Medical Center- Hillcrest, San Diego

163045

State Budgetary Healthcare Institution of Arkhangelsk Region, Arkhangelsk

197758

"FSBI National Medical Scientific Centre of Oncology n.a.N.N.Petrov of the MOH of Russia", Saint Petersburg

200347

Centrul de Oncologie Sf. Nectarie SRL, Craiova

200385

SC Oncolab SRL, Craiova

300166

S.C. ONCOCENTER Oncologie Clinica S.R.L., Timișoara

354057

"State Budgetary Healthcare Institution Oncology Center #2 of the Ministry of", Sochi

400058

SC Medisprof SRL, Cluj-Napoca

420029

State Autonomous Healthcare Institution Republican Clinical Oncology Dispensary of the Ministry, Kazan'

550245

Spitalul Clinic Judetean de Urgenta Sibiu, Clinica Oncologie Medicala, Sibiu

775 20

Fakultni nemocnice Olomouc, Olomouc

180 81

Nemocnice Na Bulovce, Centralni laboratore Pavilon c. 8, Prague

Nemocnice Na Bulovce, Lekarna, Oddeleni Centralni pripravy, Prague

Nemocnice Na Bulovce, Ustav radiacni onkologie, Prague

464-8681

Aichi cancer center Central hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

060-8648

Hokkaido University Hospital/Otolaryngology, Sapporo

411-8777

Shizuoka Cancer Center, Sunto-gun

80-211

Uniwersyteckie Centrum Kliniczne Klinika Onkologii i Radioterapii, Gdansk

93-513

Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi Oddzial Chemioterapii, Lodz

10-228

SPZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie Oddzial Kliniczny Onkologii, Olsztyn

05801

POKO Poprad, s.r.o., Poprad

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08035

Hospital Universitario Vall d'Hebron, Barcelona

03057

"Clinic of SI Institute of Otolaryngology n.a. Prof. O.S. Kolomyichenka of NAMSU", Kyiv

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT02499120 - Safety And Efficacy Study Of Palbociclib Plus Cetuximab Versus Cetuximab To Treat Head And Neck Cancer | Biotech Hunter | Biotech Hunter