NCT02498613 - A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors | Biotech Hunter

Enrollment

122

Participants

Timeline

Start Date

August 31, 2016

Primary Completion Date

June 22, 2022

Study Completion Date

April 10, 2026

Conditions

Advanced Malignant Solid NeoplasmMetastatic Lung Non-Small Cell CarcinomaMetastatic Lung Small Cell CarcinomaMetastatic Pancreatic AdenocarcinomaMetastatic Triple-Negative Breast CarcinomaPancreatic Ductal AdenocarcinomaStage III Breast Cancer AJCC v7Stage III Lung Non-Small Cell Cancer AJCC v7Stage III Lung Small Cell Carcinoma AJCC v7Stage III Pancreatic Cancer AJCC v6 and v7Stage IIIA Breast Cancer AJCC v7Stage IIIA Lung Non-Small Cell Cancer AJCC v7Stage IIIA Lung Small Cell Carcinoma AJCC v7Stage IIIB Breast Cancer AJCC v7Stage IIIB Lung Non-Small Cell Cancer AJCC v7Stage IIIB Lung Small Cell Carcinoma AJCC v7Stage IIIC Breast Cancer AJCC v7Stage IV Breast Cancer AJCC v6 and v7Stage IV Lung Non-Small Cell Cancer AJCC v7Stage IV Lung Small Cell Carcinoma AJCC v7Stage IV Pancreatic Cancer AJCC v6 and v7Triple-Negative Breast CarcinomaUnresectable Lung Small Cell CarcinomaUnresectable Pancreatic AdenocarcinomaUnresectable Pancreatic CarcinomaUnresectable Triple-Negative Breast Carcinoma

Interventions

OTHER

18F-Fluoromisonidazole

Correlative studies

DRUG

Cediranib Maleate

Given PO

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Olaparib

Given PO

PROCEDURE

Positron Emission Tomography

Correlative studies

Trial Locations (16)

23298

VCU Massey Comprehensive Cancer Center, Richmond

33607

Moffitt Cancer Center-International Plaza, Tampa

33612

Moffitt Cancer Center, Tampa

37232

Vanderbilt University/Ingram Cancer Center, Nashville

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48334

Weisberg Cancer Treatment Center, Farmington Hills

77030

M D Anderson Cancer Center, Houston

92093

UC San Diego Moores Cancer Center, La Jolla

92103

UC San Diego Medical Center - Hillcrest, San Diego

94115

UCSF Medical Center-Mount Zion, San Francisco

95817

University of California Davis Comprehensive Cancer Center, Sacramento

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

02215

Dana-Farber Cancer Institute, Boston

V5Z 4E6

BCCA-Vancouver Cancer Centre, Vancouver

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto