54
Participants
Start Date
May 31, 2015
Primary Completion Date
September 4, 2018
Study Completion Date
September 28, 2018
Physical Activity Monitoring (Actiheart)
Monitor physical activity using an Actiheart monitor during the required periods.
Energy Intake Monitoring
Monitor energy intake by weighing and recording all foods/drinks consumed during the required periods.
Body Weight Monitoring
Monitor body weight during monitoring phase to ensure stability despite other monitoring activities.
Intravenous Cannulation
Fitting of an intravenous cannula to a vein on the forearm for blood sampling during laboratory protocols.
Adipose Tissue Biopsy
This is an optional feature which if included involves the removal of a 0.5 gram sample of adipose tissue from just below the skin using a needle.
Lidocaine Hydrochloride
The anaesthetic that will be used to numb the site of the adipose tissue biopsy in the event it is included.
Post-Prandial Meal Tests
Consume two successive meals with regular blood samples throughout the ensuing hours (2-3 hours each).
DEXA Scan
Undergo a dual energy x-ray absorptiometry scan to examine body composition.
Actiheart Calibration
Submaximal treadmill test to calibrate monitoring equipment.
Daily Calorie Restriction
Reduce energy intake by 25% on a daily basis.
Intermittent Fasting with Weight Loss
Alternate between 24 hour cycles of fasting and feeding with 150% of normal intake when feeding.
Intermittent Fasting without Weight Loss
Alternate between 24 hour cycles of fasting and feeding with 200% of normal intake when feeding.
University of Bath, Bath
University of Bath
OTHER