Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases

PHASE2TerminatedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

April 30, 2016

Primary Completion Date

February 1, 2019

Study Completion Date

December 15, 2022

Conditions
RadionecrosisBrain Metastases
Interventions
DRUG

bevacizumab

IV

DRUG

corticosteroids

IV

OTHER

placebo

IV

Trial Locations (341)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

Regional Hematology and Oncology PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

Nanticoke Memorial Hospital, Seaford

25401

WVUH-Berkely Medical Center, Martinsburg

26101

Camden Clark Medical Center, Parkersburg

26330

United Hospital Center, Bridgeport

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

27203

Randolph Hospital, Asheboro

27215

Cone Health Cancer Center at Alamance Regional, Burlington

27302

Cone Heath Cancer Center at Mebane, Mebane

27320

Annie Penn Memorial Hospital, Reidsville

27403

Cone Health Cancer Center, Greensboro

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

Wayne Memorial Hospital, Goldsboro

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27834

East Carolina University, Greenville

27893

Southeastern Medical Oncology Center-Wilson, Wilson

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Onslow Memorial Hospital, Jacksonville

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29307

Greenville Health System Cancer Institute-Spartanburg, Spartanburg

29325

Greenville Health System Cancer Institute-Laurens, Clinton

29401

Roper Hospital, Charleston

29403

Charleston Hematology Oncology Associates-Roper, Charleston

29406

Lowcountry Hematology Oncology PA-North Charleston, Charleston

29414

Bon Secours Saint Francis Hospital, Charleston

Charleston Hematology Oncology Associates PA-Saint Francis, Charleston

Lowcountry Hematology Oncology PA-West Ashley, Charleston

29464

Lowcountry Hematology Oncology PA-Mount Pleasant, Mt. Pleasant

29605

Greenville Health System Cancer Institute-Butternut, Greenville

Greenville Health System Cancer Institute-Faris, Greenville

Greenville Memorial Hospital, Greenville

29615

Greenville Health System Cancer Institute-Eastside, Greenville

29640

Greenville Health System Cancer Institute-Easley, Easley

29650

Greenville Health System Cancer Institute-Greer, Greer

29672

Greenville Health System Cancer Institute-Seneca, Seneca

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30607

University Cancer and Blood Center LLC, Athens

31404

Memorial Health University Medical Center, Savannah

Summit Cancer Care-Memorial, Savannah

31405

Low Country Cancer Care Associates PC, Savannah

Summit Cancer Care-Candler, Savannah

32114

Halifax Health Medical Center-Centers for Oncology, Daytona Beach

32207

Baptist MD Anderson Cancer Center, Jacksonville

33486

Boca Raton Regional Hospital, Boca Raton

33612

Moffitt Cancer Center, Tampa

37067

Vanderbilt-Ingram Cancer Center Cool Springs, Franklin

37204

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

44307

Cleveland Clinic Akron General, Akron

45005

Dayton Physicians LLC-Atrium, Franklin

45042

Dayton Physicians LLC-Signal Point, Middletown

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45331

Dayton Physicians LLC-Wayne, Greenville

Wayne Hospital, Greenville

45365

Dayton Physicians LLC-Wilson, Sidney

45373

Dayton Physicians LLC-Upper Valley, Troy

Upper Valley Medical Center, Troy

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

Greater Dayton Cancer Center, Kettering

45415

Dayton Physicians LLC-Samaritan North, Dayton

Miami Valley Hospital North, Dayton

45420

First Dayton Cancer Care, Kettering

45429

Kettering Medical Center, Kettering

45431

Indu and Raj Soin Medical Center, Beavercreek

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

45505

Springfield Regional Medical Center, Springfield

45840

Armes Family Cancer Center, Findlay

Blanchard Valley Hospital, Findlay

Orion Cancer Care, Findlay

46219

Community Cancer Center East, Indianapolis

46227

Community Cancer Center South, Indianapolis

46256

Community Cancer Center North, Indianapolis

46545

Memorial Regional Cancer Center Day Road, Mishawaka

46601

Memorial Hospital of South Bend, South Bend

46904

Community Howard Regional Health, Kokomo

47374

Reid Health, Richmond

47630

Chancellor Center for Oncology, Newburgh

47713

Deaconess Clinic Downtown, Evansville

48044

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb

Michigan Breast Specialists-Macomb Township, Macomb

48054

Great Lakes Cancer Management Specialists-Doctors Park, East China Township

48060

Huron Medical Center PC, Port Huron

Lake Huron Medical Center, Port Huron

48066

Michigan Cancer Specialists, Roseville

48067

Oakland Colon and Rectal Association, Royal Oak

48073

Cancer Care Associates PC, Royal Oak

Comprehensive Medical Center PLLC, Royal Oak

Hematology Oncology Consultants PC, Royal Oak

Oakland Medical Group, Royal Oak

William Beaumont Hospital-Royal Oak, Royal Oak

48075

Ascension Providence Hospitals - Southfield, Southfield

48084

Michigan Institute of Urology-Town Center, Troy

48085

Claudia BR Herke MD PC, Troy

William Beaumont Hospital - Troy, Troy

48088

Advanced Breast Care Center PLLC, Warren

48093

Bhadresh Nayak MD PC-Warren, Warren

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren

Macomb Hematology Oncology PC, Warren

Michigan Breast Specialists-Warren, Warren

Saint John Macomb-Oakland Hospital, Warren

48098

Hematology Oncology Consultants PC-Troy, Troy

48106

Saint Joseph Mercy Hospital, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

IHA Hematology Oncology Consultants-Brighton, Brighton

Saint Joseph Mercy Brighton, Brighton

48118

IHA Hematology Oncology Consultants-Chelsea, Chelsea

Saint Joseph Mercy Chelsea, Chelsea

48124

Beaumont Hospital-Dearborn, Dearborn

48154

Hope Cancer Clinic, Livonia

Saint Mary Mercy Hospital, Livonia

48188

IHA Hematology Oncology Consultants-Canton, Canton

Saint Joseph Mercy Canton, Canton

48197

IHA Hematology Oncology Consultants-Ann Arbor, Ypsilanti

48230

William Beaumont Hospital-Grosse Point, Grosse Pointe

48236

Ascension Saint John Hospital, Detroit

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods

Lymphoma Clinic of Michigan, Grosse Pointe Woods

Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods

48309

Great Lakes Cancer Management Specialists-Rochester Hills, Rochester Hills

48312

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights

Premier Hematology Oncology Care, Sterling Heights

48314

Mitchell Folbe MD PC, Sterling Heights

48336

Beaumont Hospital - Farmington Hills, Farmington Hills

48341

21st Century Oncology-Pontiac, Pontiac

Hope Cancer Center, Pontiac

Newland Medical Associates-Pontiac, Pontiac

Saint Joseph Mercy Oakland, Pontiac

48346

Hematology Oncology Consultants-Clarkston, Clarkston

Newland Medical Associates-Clarkston, Clarkston

48374

Ascension Providence Hospitals - Novi, Novi

48453

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette

48503

Genesee Cancer and Blood Disease Treatment Center, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Saint Mary's of Michigan, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48723

Caro Cancer Center, Caro

48764

Saint Joseph Health System-Tawas City, Tawas City

48912

Sparrow Hospital, Lansing

49201

Allegiance Health, Jackson

50309

Iowa Methodist Medical Center, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Broadlawns Medical Center, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50501

Trinity Regional Medical Center, Fort Dodge

53792

University of Wisconsin Hospital and Clinics, Madison

54806

Ashland Memorial Medical Center, Ashland

Duluth Clinic Ashland, Ashland

55072

Essentia Health Sandstone, Sandstone

55746

Essentia Health Hibbing Clinic, Hibbing

55792

Essentia Health Virginia Clinic, Virginia

55805

Essentia Health Cancer Center, Duluth

Essentia Health Saint Mary's Medical Center, Duluth

Miller-Dwan Hospital, Duluth

55905

Mayo Clinic, Rochester

56401

Essentia Health Saint Joseph's Medical Center, Brainerd

56470

Essentia Health - Park Rapids, Park Rapids

56501

Essentia Health Saint Mary's - Detroit Lakes Clinic, Detroit Lakes

56537

Lake Region Healthcare Corporation-Cancer Care, Fergus Falls

56542

Essentia Health - Fosston, Fosston

56636

Essentia Health - Deer River Clinic, Deer River

58103

Essentia Health Cancer Center-South University Clinic, Fargo

58401

Essentia Health - Jamestown Clinic, Jamestown

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Deaconess Hospital, Bozeman

59804

Community Medical Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60504

Rush - Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

60612

Rush University Medical Center, Chicago

University of Illinois, Chicago

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle on Vermilion, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

62864

Good Samaritan Regional Health Center, Mount Vernon

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63110

Washington University School of Medicine, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64057

Centerpoint Medical Center LLC, Independence

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64111

Saint Luke's Hospital of Kansas City, Kansas City

64132

Research Medical Center, Kansas City

64507

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66209

Menorah Medical Center, Overland Park

66213

Saint Luke's South Hospital, Overland Park

66219

Kansas Institute of Medicine Cancer and Blood Center, Lenexa

Minimally Invasive Surgery Hospital, Lenexa

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

73120

Mercy Hospital Oklahoma City, Oklahoma City

77030

M D Anderson Cancer Center, Houston

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83301

Saint Luke's Mountain States Tumor Institute-Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83617

Walter Knox Memorial Hospital, Emmett

83619

Saint Luke's Mountain States Tumor Institute - Fruitland, Fruitland

83642

Idaho Urologic Institute-Meridian, Meridian

Saint Luke's Mountain States Tumor Institute - Meridian, Meridian

83686

Saint Alphonsus Medical Center-Nampa, Nampa

Saint Luke's Mountain States Tumor Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Mountain States Tumor Institute, Boise

83814

Kootenai Medical Center, Coeur d'Alene

83854

Kootenai Cancer Center, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

89048

Hope Cancer Care of Nevada-Pahrump, Pahrump

89052

Cancer and Blood Specialists-Henderson, Henderson

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson

Las Vegas Cancer Center-Henderson, Henderson

Nevada Cancer Specialists-Saint Rose, Henderson

89074

21st Century Oncology-Henderson, Henderson

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson

89102

Desert West Surgery, Las Vegas

Nevada Cancer Specialists?Oakey, Las Vegas

University Medical Center of Southern Nevada, Las Vegas

89106

Cancer and Blood Specialists-Shadow, Las Vegas

Radiation Oncology Centers of Nevada Central, Las Vegas

89109

21st Century Oncology, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas

89113

HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89121

Cancer Therapy and Integrative Medicine, Las Vegas

89128

21st Century Oncology-Vegas Tenaya, Las Vegas

Ann M Wierman MD LTD, Las Vegas

Cancer and Blood Specialists-Tenaya, Las Vegas

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas

Nevada Cancer Specialists-Tenaya, Las Vegas

89144

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

Summerlin Hospital Medical Center, Las Vegas

89148

21st Century Oncology-Fort Apache, Las Vegas

Comprehensive Cancer Centers of Nevada, Las Vegas

Nevada Cancer Specialists-Fort Apache, Las Vegas

89149

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas

89169

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

University Cancer Center, Las Vegas

89502

Renown Regional Medical Center, Reno

89503

Saint Mary's Regional Medical Center, Reno

89509

Radiation Oncology Associates, Reno

89703

Carson Tahoe Regional Medical Center, Carson City

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92093

UC San Diego Moores Cancer Center, La Jolla

93420

PCR Oncology, Arroyo Grande

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Oncology and Hematology Care Southeast, Clackamas

97045

Providence Willamette Falls Medical Center, Oregon City

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97814

Saint Alphonsus Medical Center-Baker City, Baker City

97914

Saint Alphonsus Medical Center-Ontario, Ontario

98026

Swedish Medical Center-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98112

Kaiser Permanente Washington, Seattle

98201

Providence Regional Cancer Partnership, Everett

98221

Cancer Care Center at Island Hospital, Anacortes

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99204

Rockwood Cancer Treatment Center-DHEC-Downtown, Spokane

99216

Rockwood Clinic Cancer Treatment Center-Valley, Spokane Valley

99218

Rockwood North Cancer Treatment Center, Spokane

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

32224-9980

Mayo Clinic in Florida, Jacksonville

50266-7700

Methodist West Hospital, West Des Moines

01104

Mercy Medical Center, Springfield

89148-2405

Las Vegas Cancer Center-Medical Center, Las Vegas

03301

New Hampshire Oncology Hematology PA-Concord, Concord

03106

New Hampshire Oncology Hematology PA-Hooksett, Hooksett

07631

Englewood Hospital and Medical Center, Englewood

07902

Overlook Hospital, Summit

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

98122-4307

Swedish Medical Center-First Hill, Seattle

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

V5Z 4E6

BCCA-Vancouver Cancer Centre, Vancouver

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

K1H 8L6

Ottawa Hospital and Cancer Center-General Campus, Ottawa

M4N 3M5

Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

H2L 4M1

CHUM - Hopital Notre-Dame, Montreal

H2X 3E4

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

H3T 1E2

Jewish General Hospital, Montreal

J1H 5N4

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Genentech, Inc.

INDUSTRY

lead

Alliance for Clinical Trials in Oncology

OTHER