Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,280

Participants

Timeline

Start Date

October 31, 2015

Primary Completion Date

January 26, 2024

Study Completion Date

August 30, 2035

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Atezolizumab

Participants will receive atezolizumab (1200 mg IV) Q3W for 16 cycles (cycle length=21 days).

DRUG

Cisplatin

Participants will receive cisplatin 75 milligrams per square meter (mg/m\^2) IV on Day 1 of up to four 21-day cycles.

DRUG

Vinorelbine

Participants will receive vinorelbine 30 mg/m\^2 IV on Days 1 and 8 of each of the four 21-day cycles.

DRUG

Docetaxel

Participants will receive docetaxel 75 mg/m\^2 IV on Day 1 of each of the four 21-day cycles.

DRUG

Gemcitabine

Participants will receive gemcitabine 1250 mg/m\^2 IV on Days 1 and 8 of each of the four 21-day cycles.

DRUG

Pemetrexed

Participants will receive pemetrexed 500 mg/m\^2 IV on Day 1 of each of the four 21-day cycles. Pemetrexed will be administered only in participants with non-squamous cell NSCLC.

Trial Locations (153)

333

Chang Gung Medical Foundation Linkou Branch, Taoyuan

500

Changhua Christian Hospital, Changhua

1200

Cliniques Universitaires St-Luc, Brussels

3144

Cabrini Hospital Malvern, Malvern

3820

Hospital Universitario de Canarias, San Cristóbal de La Laguna

4000

CHU de Liège (Sart Tilman), Liège

4814

Townsville Hospital, Douglas

5004

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rend.Int., Szolnok

7624

University of Pecs, I st Dept of Internal Medicine, Pécs

10043

Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano

10065

Weill Cornell Medical College, New York

10126

Azienda Ospedaliera Città della Salute e della Scienza di Torino, Turin

11042

Clinical Research Alliance, Lake Success

12002

Consorcio Hospitalario Provincial de Castellon, Castellon

13125

Evang. Lungenklinik Berlin Klinik für Pneumologie, Berlin

14004

C.H. Regional Reina Sofia, Córdoba

21018

Communal Nonprofit Enterprise Podilsky Regional Center Of Oncology OfTheVinnytsia Regional Council, Vinnytsia

22408

Hematology Oncology Associates of Fredericksburg, Inc., Fredericksburg

22927

LungenClinic Grosshansdorf GmbH, Großhansdorf

23007

Complejo Hospitalario de Jaen, Jaén

24127

Asst Papa Giovanni XXIII, Bergamo

24201

Wellmont Medical Associates, Bristol

25123

ASST Spedali Civili di Brescia, Brescia

26121

Pius-Hospital Oldenburg, Oldenburg

27003

Hospital Lucus Augusti, Lugo

28046

Hospital Universitario La Paz, Madrid

28050

Hospital Universitario HM Sanchinarro-CIOCC, Madrid

28204

Presbyterian Hospital, Charlotte

30120

Hospital Universitario Virgen de La Arrixaca, El Palmar

31096

Rambam Medical Center, Haifa

31792

Lewis Hall Singletary Oncology Center, Thomasville

33170

Azienda per l'Assistenza Sanitaria N° 5 - Friuli Occidentale, Pordenone

33442

University of Miami School of Medicine - Sylvester at Deerfield, Deerfield Beach

33486

Lynn Cancer Institute - West, Boca Raton

33611

Ev.Krankenhaus Bielefeld gGmbH, Bielefeld

33705

SCRI Florida Cancer Specialists North, St. Petersburg

34070

Clinique Clémentville, Montpellier

34298

Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque, Montpellier

34376

Fachklinik für Lungenerkrankungen, Immenhausen

37126

Azienda Ospedaliera Universitaria Integrata Verona, Verona

37403

University Oncology Associates, Chattanooga

38100

Ospedale Santa Chiara, Trento

38114

Stadtisches Klinikum Braunschweig, Braunschweig

39008

Hospital Universitario Marques de Valdecilla, Santander

40000

Centre Hospitalier de Mont de Marsan - Hopital Layne, Mont-de-Marsan

40022

Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary, Sumy

40402

Norton Cancer Institute, Louisville

40705

Taichung Veterans General Hospital, Taichung

44093

Centre René Gauducheau Centre de Lutte Contre Le Cancer Nantes Atlantique, Nantes

44281

Meir Medical Center, Kfar Saba

45219

University of Cincinnati, Cincinnati

45242

Oncology Hematology Care - SCRI, Cincinnati

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

48149

Gemeinschaftspraxis für Hämatologie und Onkologie, Münster

49102

MI Dnipropetrovsk City Multifield Clinical Hospital 4 of Dnipropetrovsk Regional Council, Dnipropetrovsk

50009

Hosp Clinico Univ Lozano Blesa, Zaragoza

50048

CE Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council, Kryvyi Rih

52621

Chaim Sheba Medical Center, Tel Litwinsky

56073

Katholisches Klinikum Marienhof, Koblenz Am Rhein

56124

Azienda Ospedaliero Universitaria Pisana, Pisa

58100

Edith Wolfson Medical Center, Holon

58675

Lungenklinik Hemer, Hemer

60488

Krankenhaus Nordwest, Frankfurt am Main

60569

Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu, Poznan

60612

University of Illinois at Chicago, Chicago

61070

Communal Non profit Enterprise Regional Center of Oncology, Kharkiv

61363

Chang Gung Memorial Hospital Chiayi, Putzui City

61615

Illinois Cancer Care, Peoria

64111

St. Luke's Cancer Institute, Kansas City

64239

Tel Aviv Sourasky Medical Ctr, Tel Aviv

65055

Municipal Institution Odesa Regional Oncology Dispensary, Odesa

66013

Ospedale Clinicizzato SS Annunziata, Chieti

66421

Universität Des Saarlandes, Homburg

69040

MI Zaporizhzhia Regional Clinical Oncological Dispensary Zaporizhzhia SMU Ch of Oncology, Zaporizhzhya

72703

Highlands Oncology Group, Fayetteville

76018

Municipal Institution SubCarpathian ClinicalOncological Centre, Ivano-Frankivsk

76137

Vincentius-Diakonissen-Kliniken gAG, Karlsruhe

77030

Houston Methodist Cancer Center, Houston

81925

Klinikum Bogenhausen, München

83041

Hopital d Instruction des Armees de Sainte Anne, Toulon

90024

University of California Los Angeles, Los Angeles

92024

California Cancer Associates for Research & Excellence, Inc., Encinitas

92708

Compassionate Cancer Care Medical Group, Inc, Fountain Valley

93049

Krankenhaus Barmherzige Bruder Regensburg, Regensburg

94589

Kaiser Permanente, Vallejo

94596

Kaiser Permanente - Walnut Creek, Walnut Creek

95122

Azienda Ospedaliera Di Rilievo Nazionale E Di Alta Specializzazione Garibaldi, Catania

97239

Oregon Health and Science University, Portland

97448

Centre Hospitalier Regional Sud Reunion, Saint-Pierre

98122

Swedish Medical Center, Seattle

98201

Providence Everett Med Ctr, Everett

100021

Cancer Institute and Hospital Chinese Academy of Medical Sciences, Beijing

105229

Principal Military Clinical Hospital n.a. N.N. Burdenko, Moscow

110001

First Hospital of China Medical University, Shenyang

110042

Liaoning Provincial Cancer Hospital, Shengyang

150040

Regional Clinical Oncology Hospital, Yaroslavl

194291

Leningrad Regional Clinical Hospital, Saint Petersburg

197758

GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology), Saint Petersburg

Scientific Research Institute of Oncology n.a. N.N. Petrov, Saint Petersburg

200030

Shanghai Chest Hospital, Shanghai

200433

Shanghai Pulmonary Hospital, Shanghai

200542

Oncology Center Sf. Nectarie, Craiova

215006

First Affiliated Hospital of Soochow University, Suzhou

310022

Zhejiang Cancer Hospital, Hangzhou

400138

Volgograd Regional Clinical Oncology Dispensary, Volgograd

510120

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

630047

City Clinical Hospital #1, Novosibirsk

06360

Eastern Connecticut Hematology and Oncology Associates, Norwich

07932

Hematology Oncology Associates of Northern New Jersey, Florham Park

07039

Saint Barnabas Medical Center, Livingston

07652

Valley Hospital, Paramus

07901

Overlook Medical Center, Summit

98002-4117

MultiCare Regional Cancer Center - Auburn, Auburn

Unknown

Anhui Province Cancer Hospital, Hefei

Prince of Wales Hosp, Shatin

02321

Centre Hospitalier de Saint-Quentin, Saint-Quentin

09113

Klinikum Chemnitz gGmbH, Chemnitz

00128

Policlinico Universitario Campus Biomedico Di Roma, Rome

06132

Ospedale Silvestrini, Perugia

464-8681

Aichi Cancer Center Hospital, Aichi

673-0021

Hyogo Cancer Center, Akashi

113-8431

Juntendo University Hospital, Bunkyō City

113-8677

Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Bunkyō City

104-0045

National Cancer Center Hospital, Chūō

812-8582

Kyushu University Hospital, Fukuoka

734-8551

Hiroshima University Hospital, Hiroshima

362-0806

Saitama Cancer Center, Kitaadachi-gun

807-8555

Hospital of the University of Occupational and Environmental Health,Japan, Kitakyushu-shi

860-8556

Kumamoto University Hospital, Kumamoto

606-8507

Kyoto University Hospital, Kyoto

791-0280

Shikoku Cancer Center, Matsuyama

181-0004

Kyorin University Hospital, Mitaka-shi

951-8566

Niigata Cancer Center Hospital, Niigata

700-8558

Okayama University Hospital, Okayama

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

105-8470

Toranomon Hospital, Tokyo

160-0023

Tokyo Medical University Hospital, Tokyo

241-8515

Kanagawa Cancer Center, Yokohama-shi, Asahi-ku

5223 GZ

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

3430 EM

St. Antonius Ziekenhuis Nieuwegein, Nieuwegein

05-400

Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy, Otwock

3000-602

Centro Hospitalar E Universitário de Coimbra EPE, Coimbra

4200-072

Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe, Porto

4200-319

Hospital de Sao Joao, Porto

519-763

Chonnam National University Hwasun Hospital, Jeonnam

442-723

The Catholic University of Korea St. Vincent's Hospital, Suwon

08003

Hospital del Mar, Barcelona

08025

Hospital Santa Creu i Sant Pau, Barcelona

08035

Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

00112

Taipei Veterans General Hospital, Taipei

03115

Kyiv City Clinical Oncological Center, Kyiv

CO4 5JL

Colchester General Hospital, Colchester, Essex

EC1A 7BE

St Bartholomew's Hospital, London

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY