6
Participants
Start Date
July 31, 2015
Primary Completion Date
December 31, 2016
Study Completion Date
April 30, 2017
Cyclophosphamide
Cyclophosphamide 60 mg/kg is administered i.v. on day -7 and day -6.
Fludarabine
Fludarabine 25 mg/m2 is administered on day -5 to day -1.
TIL infusion
The maximum number of expanded TILs are infused over 30-45 minutes on day 0.
Interleukin-2
Interleukin-2 is administered as a continous i.v. infusion in a decrescendo regimen (18 MIU/m3 IL-2 over 6 hours, 18 MIU/m2 IL-2 over 12 hours, 18 MIU/m2 IL-2 over 24 hours followed by 4,5 MIU/m2 IL-2 over another 24 hours for three days).
Center for Cancer Immune Therapy Dept. of Hematology/oncology, Copenhagen
Inge Marie Svane
OTHER