A Study Of PF-06410293 (Adalimumab-Pfizer) And Adalimumab (Humira®) In Combination With Methotrexate In Subjects With Active Rheumatoid Arthritis (REFLECTIONS B538-02).

PHASE3CompletedINTERVENTIONAL
Enrollment

597

Participants

Timeline

Start Date

June 25, 2015

Primary Completion Date

August 31, 2016

Study Completion Date

December 6, 2017

Conditions
Rheumatoid Arthritis
Interventions
BIOLOGICAL

PF-06410293

PF-06410293 will be administered with a uniform dose regimen, which is SC injection at a dose of 40 mg every other week, throughout the study treatment.

BIOLOGICAL

Adalimumab

Adalimumab will be administered with a uniform dose regimen, which is SC injection at a dose of 40 mg every other week, throughout the study treatment.

Trial Locations (183)

1036

Qualiclinic Kft., Budapest

1612

"UMHAT Sv. Ivan Rilski EAD", Sofia

"University Multiprofile Hospital for Active Treatment Sv. Ivan Rilski EAD", Sofia

1619

Clinresco Centres (Pty) Ltd, Kempton Park

2193

Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg

2200

Unimedi Kakheti Ltd, Telavi Referral Hospital, Telavi

3204

Waikato Hospital, Hamilton

4000

MHAT Plovdiv AD, Plovdiv

4001

St. Augustine's Hospital, Durban

4002

University Multiprofile Hospital for Active Treatment (UMHAT) Kaspela EOOD, Plovdiv

4215

Paradise Arthritis & Rheumatology Pty Ltd, Southport

5011

The Queen Elizabeth Hospital, Woodville South

6010

"LTD Unimed Adjara", Batumi

6021

Wellington Hospital, Capital Coast District Health Board, Wellington

6100

RK Will Pty Ltd, Victoria Park

7405

Arthritis Clinical Research Trials, Dr. C.E Spargo and Dr. R.B Bhorat Practice, Cape Town

7500

Panorama Medical Centre, Cape Town

7940

MedLab, Timaru

Timaru Hospital, Timaru

Timaru Rheumatology Studies, Timaru

8200

Vital Medical Center Orvosi es Fogorvosi Kozpont, Veszprém

10016

Manhattan Medical Research, New York

10117

Innomedica OÜ, Tallinn

11000

Institute of Rheumatology, Belgrade

Military Medical Academy,, Belgrade

11031

Taipei Medical University Hospital, Taipei

11312

East Tallinn Central Hospital, Tallinn

14059

Schlosspark-Klinik, Berlin

14127

Buffalo Rheumatology and Medicine PLLC, Orchard Park

15006

Hospital Universitario A Coruña, A Coruña

16635

Altoona Center for Clinical Research, Duncansville

18205

Institute for Treatment and Rehabilitation Niska Banja, Niška Banja

19610

Clinical Research of Reading, LLC, Wyomissing

19713

Javed Rheumatology Associates, Inc, Newark

20902

The Center for Rheumatology and Bone Research, Wheaton

21018

Vinnytska oblasna klinichna likarnia im. M.I.Pyrohova revmatolohichne viddilennia, Vinnytsia

21100

Consultorio Medico Privado de Reumatologia, Mexicali

21112

Special Hospital for Rheumatic Diseases Novi Sad, Novi Sad

23320

Center for Arthritis and Rheumatic Diseases, P.C., Chesapeake

25801

Rheumatology and Pulmonary Clinic, Beckley

27834

Physicians East PA, Greenville

28034

Hospital Universitario Ramón y Cajal, Madrid

28942

Hospital Universitario de Fuenlabrada, Fuenlabrada

29406

Low Country Rheumatology, PA, Charleston

31134

Gemeinschaftspraxis Dr. von Hinüber/Dr. Demary, Hildesheim

32117

International Medical Research, Daytona Beach

32607

SIMED Arthritis Center, Gainesville

Southeastern Integrated Medical, PL, d/b/a Florida Medical Research, Gainesville

32806

Rheumatology Associates of Central Florida, P.A., Orlando

32960

Alastair C. Kennedy, MD, Vero Beach

Indian River Primary Care, Vero Beach

33180

Arthritis and Rheumatic Disease Specialties, Aventura

33765

Robert W. Levin, MD, PA, Clearwater

34239

Sarasota Arthritis Research Center, Sarasota

38119

Ramesh C Gupta, M.D., Memphis

38305

West Tennessee Research Institute, Jackson

38801

North Mississippi Medical Clinics, Inc. - Clinical Research, Tupelo

40022

"Komunalnyi zaklad Sumskoi oblasnoi rady Sumska oblasna klinichna", Sumy

40201

Chung Shan Medical University Hospital, Taichung

40447

China Medical University Hospital, Taichung

40878

Rheumazentrum Ratingen, Ratingen

41010

Hospital Infanta Luisa, Seville

42101

Graves-Gilbert Clinic Bowling Green, Bowling Green

45242

Cincinnati Rheumatic Disease Study Group, Inc., Cincinnati

48903

Hospital Universitario Cruces, Barakaldo

49015

Bronson Internal Medicine and Rheumatology, Battle Creek

52403

Physician's Clinic of Iowa, P.C., Cedar Rapids

57701

Regional Health Clinical Research, Rapid City

Regional Medical Clinic - Rheumatology, Rapid City

61176

"Komunalnyi zaklad okhorony zdorovia Kharkivska miska klinichna likarnia #8", M. Kharkiv

61469

Chonnam National University Hospital, Gwangju

65026

Bahatoprofilnyi medychnyi tsentr (Universytetska klinika #1), Odesa

66346

Knappschaftsklinikum Saar GmbH, Püttlingen

68114

Westroads Clinical Research, Inc., Omaha

68516

Physician Research Collaboration, LLC, Lincoln

69600

"Komunalna ustanova Zaporizka oblasna klinichna likarnia Zaporizkoi oblasnoi rady", Zaporizhzhia

75150

Southwest Rheumatology Research, LLC, Mesquite

75231

Metroplex Clinical Research Center, Dallas

77090

The Clinical Research Institute of Houston, LLC, Houston

77380

Northwest Diagnostic Clinic, PA, Shenandoah

77573

Accurate Clinical Research, League City

78731

Austin Regional Clinic, Austin

79010

Lvivskyi oblasnyi klinichnyi diahnostychnyi tsentr,, Lviv

79011

Komunalna 4-a miska klinichna likarnia m. Lvova,, Lviv

79124

Amarillo Center for Clinical Research, Ltd., Amarillo

80336

Klinikum der Universität München, München

81541

Praxiszentrum St. Bonifatius, München

82152

Rheumapraxis Dr. Martin Welcker und Kollegen, Planegg

83642

St Luke' s Clinic, Meridian

83702

St Luke's Intermountain Research Center, Boise

85032

Arizona Arthritis & Rheumatology Associates, PC, Phoenix

85234

ArthroCare, Arthritis Care & Research P.C., Gilbert

85306

Arizona Arthritis & Rheumatology Associates, PC, Glendale

91360

Westlake Medical Research, Thousand Oaks

91786

Inland Rheumatology Clinical Trials, Inc., Upland

92395

Desert Valley Medical Group, Victorville

92835

St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare, Fullerton

94578

East Bay Rheumatology Medical Group, Inc., San Leandro

98801

Wenatchee Valley Hospitals & Clinics, Wenatchee

119049

Municipal Clinical Hospital No. 1 Named after N.I. Pirogov, Moscow

129327

GBUZ of city of Moscow City clinical hospital n.a. A.K.Eramishantsev of Ministry of Healthcare of, Moscow

150002

"GBKUZ of Yaroslavl region City hospital n. a. N.A. Semashko", Yaroslavl

185019

GBUZ Republican hospital n.a. V.A. Baranov, Petrozavodsk

190068

"Spb GBUZ Clinical rheumatology hospital # 25 City CDC prevention of osteoporosis", Saint Petersburg

305007

GMU Kursk Regional Clinical Hospital of the Healthcare Committee of the Kursk Region, Kursk

390026

GBOU VPO Ryazan State Medical University Named after Academician I.P. Pavlov, Ryazan

GBU of Ryazan region Regional clinical cardiology dispanser, Ryazan

410053

"GUZ Regional clinical hospital", Saratov

426035

LLC Alliance Biomedical Ural group, Izhevsk

460000

Orenburg State Medical Academy, Orenburg

460018

Regional Clinical Hospital, Orenburg

600023

GBUZ VO Regional clinical hospital, Vladimir

650000

"GAUZ of Kemerovo Region Regional clinical hospital for war veterans", Kemerovo

08043

Arthritis, Rheumatic & Back Disease Associates, P.A., Voorhees Township

80440-080

EDUMED Educação em Saúde S/S Ltda, Curitiba

Unknown

Fundacion Instituto de Reumatologia Fernando Chalem, Bogotá

792 01

Lekarna Na vrsku, Bruntál

Revmatologie Bruntal, s.r.o., Bruntál

748 01

L.K.N. Arthrocentrum, s.r.o., Hlučín

702 00

Lekarna Vesalion, Ostrava

530 02

Benu Lekarna, Pardubice

CCBR-SYNARC, a.s., Pardubice

128 50

Revmatologicky ustav, Prague

686 01

Lekarna Hradebni s.r.o., Uherské Hradiště

MEDICAL PLUS, s.r.o., Uherské Hradiště

0102

V.Tsitlanadze Scientifically-Practical Rheumatology Center LTD, Tbilisi

0105

V.Tsitlanadze Scientifically-Practical Rheumatology Center, Tbilisi

0112

"LTD Israeli-Georgian Medical Research Clinic Helsicore", Tbilisi

0159

LTD Cardio-Reanimation Center, Tbilisi

Tbilisi Heart and Vascular Clinic LTD, Tbilisi

0160

LTD Altravita, Tbilisi

LTD.MediClubGeorgia, Tbilisi

0177

JSC Medical Corporation Evex, Tbilisi

H-4032

Debreceni Egyetem Klinikai Központ, Debrecen

446-8602

Anjo Kosei Hospital, Anjo-shi

370-0053

Inoue Hospital, Takasaki

070-8644

National Hospital Organization Asahikawa Medical Center, Asahikawa

078-8243

Katayama Orthopaedic Rheumatology Clinic, Asahikawa

060-8604

Sapporo City General Hospital, Sapporo

060-8648

Hokkaido University Hospital, Sapporo

673-1462

Matsubara Mayflower Hospital, Katō

856-8562

National Hospital Organization Nagasaki Medical Center, Ōmura

350-8550

Saitama Medical Center, Kawagoe

359-1111

Hirose Clinic, Tokorozawa

810-0001

Kondo clinic for rheumatism and orthopaedics, Fukuoka

810-8563

National Hospital Organization Kyushu Medical Center, Fukuoka

LT-50161

LSMUL Kauno klinikos, Kaunas

LT-92288

Klaipedos universitetine ligonine, Klaipėda

LT-08661

Vilniaus universiteto ligonines Santariskiu klinikos, Vilnius

CP 07760

Consultorio de Reumatologia, Mexico City

CP656

Unidad de Investigacion en Medicina Interna y Enfermedades Criticas, Arequipa

04020

Oficina administrativa, Arequipa, Arequipa

Lima 21

ABK REUMA SRL-Medicentro Biociencias Peru SRL, Lima

Lima 31

Clinica Medica Cayetano Heredia, Lima

Lima 33

Centro de Investigación para el Estudio de Enfermedades Reumáticas, Lima

Instituto de Ginecología y Reproducción & Cirugía Mínimamente Invasiva, Lima

Oficina Administrativa, Lima Lima

15-099

Gabinet Internistyczno-Reumatologiczny Piotr Adrian Klimiuk, Bialystok

15-351

NZOZ Zdrowie Osteo-Medic s.c., Bialystok

82-300

Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka Partnerska, Elblag

NZOZ Centrum Reumatologiczne Indywidualna Specjalistyczna Praktyka Lekarska Lek. med. Barbara Bazela, Elblag

81-537

Synexus Polska Sp. z o.o. Oddzial w Gdyni, Gdynia

40-040

Synexus Polska Sp. z o.o. Oddzial w Katowicach, Katowice

40-081

Centrum Medyczne Pratia Katowice, Katowice

20-582

"Zespol Poradni Specjalistycznych REUMED Filia nr 2", Lublin

05-830

NZOZ Lecznica MAK-MED. S.C., Nadarzyn

61-397

Prywatna Praktyka Lekarska Prof. UM Dr Hab. Med. Pawel Hrycaj, Poznan

87-100

Niepubliczny Zaklad Opieki Zdrowotnej ''Nasz Lekarz'', Torun

01-192

Synexus Polska Sp. z o.o. Oddzial w Warszawie, Warsaw

01-518

Centrum Medyczne AMED, Warsaw

02-106

MTZ Clinical Research Sp. z o.o., Warsaw

02-118

''Rheuma Medicus'' Zakład Opieki Zdrowotnej, Warsaw

50-381

Synexus Polska Sp. z o.o. Oddział we Wroclawiu, Wroclaw

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05030

Konkuk University Medical Center, Seoul

133-817

Hanyang University Seoul Hospital, Seoul

03680

Kyivska miska klinichna likarnia #6, Kyiv

04107

"Komunalnyi zaklad Kyivskoi oblasnoi rady Kyivska oblasna klinichna likarnia,", M. Kyiv,

RG24 9NA

Basingstoke and North Hampshire Hospital, Hampshire Hospitals NHS Foundation Trust, Basingstoke

CH49 5PE

Arrowe Park Hospital, Wirral University Teaching Hospitals NHS Foundation Trust, Metropolitan Borough of Wirral

BA1 1RL

Royal United Hospital Bath NHS Foundation Trust ,Royal National Hospital for Rheumatic Diseases, Bath

LS7 4SA

The Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY