An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)

PHASE3CompletedINTERVENTIONAL
Enrollment

2,748

Participants

Timeline

Start Date

August 5, 2015

Primary Completion Date

October 25, 2024

Study Completion Date

October 25, 2024

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Nivolumab

DRUG

Ipilimumab

DRUG

Carboplatin

DRUG

Cisplatin

DRUG

Gemcitabine

DRUG

Pemetrexed

DRUG

Paclitaxel

Trial Locations (290)

0

Local Institution - 0324, Zhengzhou

Local Institution - 0347, Nanchang

Local Institution - 0328, Changsha

Local Institution - 0345, Kunming

Local Institution - 0374, Shantou

Local Institution - 0273, Pereira

Local Institution - 0237, Bogotá

Local Institution - 0238, Bogotá

Local Institution - 0229, Besançon

Local Institution - 0055, Galway

Local Institution - 0100, Limerick

Local Institution - 0262, Lima

Local Institution - 0263, Lima

27

Local Institution - 0350, Lima

34

Local Institution - 0261, Lima

100

Local Institution - 0138, Taipei

112

Local Institution - 0140, Taipei

235

Local Institution - 0310, Taipei

333

Local Institution - 0141, Taoyuan

407

Local Institution - 0139, Taichung

1011

Local Institution - 0244, Lausanne

1025

Local Institution - 0176, Ciudad de Buenos Aires

1083

Local Institution - 0025, Budapest

1090

Local Institution - 0240, Vienna

1121

Local Institution - 0024, Budapest

1181

Local Institution - 0172, Ciudad Autonoma de Buenos Aire

1426

Local Institution - 0171, Capital Federal

1880

Local Institution - 0170, Berazategui

1936

Local Institution - 0305, Vereeniging

2148

Local Institution - 0301, Blacktown

2196

Local Institution - 0234, Sandton

Local Institution - 0233, Saxonwold, Johannesburg

2250

Local Institution - 0300, Gosford

2340

Local Institution - 0183, North Tamworth

2605

Local Institution - 0182, Garran

2650

Local Institution - 0030, Edegem

3065

Local Institution - 0042, Fitzroy

3168

Local Institution - 0043, Clayton

3233

Local Institution - 0026, Mátraháza

3500

Local Institution - 0117, Hasselt

4000

Local Institution - 0130, San Miguel de Tucumán

4031

Local Institution - 0243, Basel

4102

Local Institution - 0045, Brisbane

4600

Local Institution - 0239, Wels

5000

Local Institution - 0268, Córdoba

5016

Local Institution - 0272, Córdoba

5112

Local Institution - 0046, Elizabeth Vale

6060

Local Institution - 0034, Gilly

6150

Local Institution - 0180, Perth

Local Institution - 0040, Murdoch

7000

Local Institution - 0246, Chur

7600

Local Institution - 0296, Mar del Plata

8036

Local Institution - 0241, Graz

8401

Local Institution - 0245, Winterthur

8500

Local Institution - 0177, Viedma

8800

Local Institution - 0121, Roeselare

9000

Local Institution - 0031, Ghent

9100

Local Institution - 0033, Sint-Niklaas

10065

Local Institution - 0019, New York

13125

Local Institution - 0208, Berlin

13915

Local Institution - 0215, Marseille

14076

Local Institution - 0283, Caen

14080

Local Institution - 0193, Mexico City

14263

Local Institution - 0005, Buffalo

18103

Local Institution - 0007, Allentown

18547

Local Institution - 0190, Neo Faliro

18840

Local Institution - 0015, Sayre

19047

Local Institution - 0075, Langhorne

19107

Local Institution - 0299, Philadelphia

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20141

Local Institution - 0083, Milan

20520

Local Institution - 0271, Turku

22927

Local Institution - 0203, Großhansdorf

24127

Local Institution - 0179, Bergamo

28041

Local Institution - 0065, Madrid

28222

Local Institution - 0064, Majadahonda

28644

Local Institution - 0249, Cheongju-si

29425

Local Institution - 0008, Charleston

29605

Local Institution - 0080, Greenville

29607

Local Institution - 0010, Greenville

30060

Local Institution - 0013, Marietta

30322

Local Institution - 0001, Atlanta

31217

Local Institution - 0192, Chihuahua City

33604

Local Institution - 0227, Pessac

36608

Southern Cancer Center, Inc., Mobile

37232

Local Institution - 0020, Nashville

39120

Local Institution - 0231, Magdeburg

40138

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna

40503

Local Institution - 0004, Lexington

41013

Local Institution - 0069, Seville

42271

Local Institution - 0221, Saint-Priest-en-Jarez

43210

Local Institution - 0009, Columbus

44106

Local Institution - 0014, Cleveland

44270

Local Institution - 0197, Guadalajara

44280

Local Institution - 0191, Zapopan

44281

Local Institution - 0186, Kfar Saba

44805

Local Institution - 0217, Saint-Herblain

45147

Local Institution - 0205, Essen

46014

Local Institution - 0068, Valencia

48121

Ospedale Santa Maria delle Croci, Ravenna

49055

Local Institution - 0216, Angers

49100

Local Institution - 0185, Petah Tikva

50180

Local Institution - 0194, Toluca

52621

Local Institution - 0184, Tel Litwinsky

54007

Local Institution - 0101, Thessaloniki

54769

Local Institution - 0198, Cuautitlán

57124

Local Institution - 0084, Livorno

58000

Local Institution - 0267, Morelia

58675

Local Institution - 0214, Hemer

60590

Local Institution - 0210, Frankfurt

63110

Local Institution - 0115, St Louis

64060

Local Institution - 0277, Monterrey

65199

Local Institution - 0212, Wiesbaden

67000

Local Institution - 0224, Strasbourg

69126

Local Institution - 0202, Heidelberg

69677

Local Institution - 0222, Bron

70300

Local Institution - 0188, Ẕerifin

70376

Local Institution - 0201, Stuttgart

75018

Local Institution - 0230, Paris

75390

Local Institution - 0003, Dallas

76000

Local Institution - 0225, Rouen

77030

Local Institution - 0102, Houston

78200

Local Institution - 0195, San Luis Potosí City

78213

Local Institution - 0236, San Luis Potosí City

80131

Istituto Nazionale Tumori Fondazione Pascale, Napoli

81925

Local Institution - 0204, München

83024

Azienda Ospedaliera Moscati, Avellino

83056

Local Institution - 0226, Toulon

84108

Local Institution - 0011, Salt Lake City

87042

Local Institution - 0228, Limoges

87509

Local Institution - 0206, Immenstadt im Allgäu

90029

Local Institution - 0270, Oulu

91120

Local Institution - 0187, Jerusalem

94010

Local Institution - 0218, Créteil

94115

Local Institution - 0017, San Francisco

97070

Local Institution - 0303, Mérida

98125

Policlinico G. Martino, Messina

99336

Local Institution - 0074, Kennewick

99437

Local Institution - 0213, Bad Berka

100001

Local Institution - 0313, Beijing

100021

Local Institution - 0315, Beijing

Local Institution - 0316, Beijing

100032

Local Institution - 0314, Beijing

110000

Local Institution - 0359, Shenyang

115478

Local Institution - 0022, Moscow

130012

Local Institution - 0329, Changchun

130021

Local Institution - 0361, Changchun

150081

Local Institution - 0325, Haerbin

166830

Local Institution - 0286, Beirut

194291

Local Institution - 0028, Saint Petersburg

197758

Local Institution - 0049, Saint Petersburg

198255

Local Institution - 0027, Saint Petersburg

200030

Local Institution - 0336, Shanghai

Local Institution - 0337, Shanghai

200032

Local Institution - 0334, Shanghai

200542

Local Institution - 0167, Craiova

230001

Local Institution - 0380, Hefei

266061

Local Institution - 0360, Qingdao

300060

Local Institution - 0373, Tianjin

310003

Local Institution - 0343, Hangzhou

310009

Local Institution - 0370, Hangzhou

310016

Local Institution - 0341, Hangzhou

310022

Local Institution - 0342, Hangzhou

350330

Local Institution - 0223, Rennes

400015

Local Institution - 0166, Romania

400037

Local Institution - 0365, Chongqing

400038

Local Institution - 0364, Chongqing

400042

Local Institution - 0378, Chongqing

407280

Local Institution - 0250, Floreşti

410013

Local Institution - 0362, Changsha

420029

Local Institution - 0142, Kazan'

430024

Local Institution - 0375, Wuhan

450052

Local Institution - 0379, Zhengzhou

450054

Local Institution - 0143, Ufa

454048

Local Institution - 0137, Chelyabinsk

510060

Local Institution - 0322, Guangzhou

510080

Local Institution - 0319, Guanzhou

510095

Local Institution - 0372, Guangzhou

570311

Local Institution - 0323, Haikou

610041

Local Institution - 0376, Chengdu

710038

Local Institution - 0333, Xi'an

710061

Local Institution - 0371, Xi'an

830011

Local Institution - 0340, Ürümqi

1040045

Local Institution - 0147, Chuo-ku

1358550

Local Institution - 0149, Koto-ku

1600023

Local Institution - 0278, Shinjuku-ku

2210855

Local Institution - 0161, Yokohama

2360051

Local Institution - 0150, Yokohama

2778577

Local Institution - 0148, Kashiwa-shi

3501298

Local Institution - 0353, Hidaka-shi

3620806

Local Institution - 0256, Kitaadachi-gun

3730828

Local Institution - 0255, Ota-shi

4118777

Local Institution - 0151, Sunto-gun

4600001

Local Institution - 0153, Nagoya

4648681

Local Institution - 0152, Nagoya

5340021

Local Institution - 0154, Osaka

5698686

Local Institution - 0257, Takatsuki-shi

5731191

Local Institution - 0155, Hirakata-shi

5890014

Local Institution - 0251, Osakasayama-shi

6500047

Local Institution - 0156, Kobe

6738558

Local Institution - 0252, Akashi-shi

7100052

Local Institution - 0158, Kurashiki-shi

7308518

Local Institution - 0258, Hiroshima

7500921

Local Institution - 0173, Santiago

7550241

Local Institution - 0354, Ube-shi

8120054

Local Institution - 0160, Fukuoka

8300011

Local Institution - 0259, Kurume-shi

8420383

Local Institution - 0131, Santiago

9208641

Local Institution - 0146, Kanazawa

9518566

Local Institution - 0164, Niigata

9800873

Local Institution - 0254, Sendai

9808574

Local Institution - 0145, Sendai

9811293

Local Institution - 0275, Natori-shi

06520

Local Institution - 0021, New Haven

19111-2412

Local Institution - 0012, Philadelphia

75390-8852

Local Institution - 0306, Dallas

X50004FHP

Local Institution - 0297, Córdoba

40170-110

Local Institution - 0125, Salvador

98700-000

Local Institution - 0124, Ijuí

90610-000

Local Institution - 0123, Porto Alegre

14784-400

Local Institution - 0127, Barretos

20231-050

Local Institution - 0129, Rio de Janeiro

01321-001

Local Institution - 0144, São Paulo

01509-010

Local Institution - 0126, São Paulo

05403-010

Local Institution - 0128, São Paulo

T6G 1Z2

Local Institution - 0103, Edmonton

A1B 3V6

Local Institution - 0290, St. John's

N6A 5W9

Local Institution - 0104, London

H3T 1E2

Local Institution - 0122, Montreal

G1J 1Z4

Local Institution - 0106, Québec

G1V 4G5

Local Institution - 0302, Québec

G5L 5T1

Local Institution - 0107, Rimouski

J1H 5N4

Local Institution - 0291, Sherbrooke

G8Z 3R9

Local Institution - 0292, Trois-Rivières

254 0364

Local Institution - 0174, Viña del Mar

050034

Local Institution - 0282, Medellín

500 05

Local Institution - 0112, Hradec Králové

779 00

Local Institution - 0113, Olomouc

140 59

Local Institution - 0111, Prague

261 01

Local Institution - 0232, Příbram

07548

Local Institution - 0211, Gera

06120

Local Institution - 0209, Halle

115 27

Local Institution - 0094, Athens

711 10

Local Institution - 0095, Heraklion

Unknown

Local Institution - 0054, Dublin

Dublin 9

Local Institution - 0053, Beaumont

06132

Local Institution - 0087, Perugia

00144

Ifo-Istituto Regina Elena, Roma

00161

Local Institution - 0089, Roma

05100

Local Institution - 0085, Terni

791-0280

Local Institution - 0159, Matsuyama

0030804

Local Institution - 0163, Sapporo

0608648

Local Institution - 0253, Sapporo

641-8510

Local Institution - 0157, Wakayama

260-8677

Local Institution - 0260, Chiba

700-8558

Local Institution - 0165, Okayama

113-8603

Local Institution - 0162, Tokyo

00961

Local Institution - 0287, Beirut

06720

Local Institution - 0196, Df

1066 CX

Local Institution - 0036, Amsterdam

1081 HV

Local Institution - 0189, Amsterdam

4818 CK

Local Institution - 0169, Breda

3014 GD

Local Institution - 0037, Rotterdam

5504 DB

Local Institution - 0039, Veldhoven

Lima 41

Local Institution - 0351, Lima

85-796

Local Institution - 0060, Bydgoszcz

80-19

Local Institution - 0058, Gdansk

81-519

Local Institution - 0063, Gdynia

44-101

Local Institution - 0072, Gliwice

93-513

Local Institution - 0057, Lodz

02-781

Local Institution - 0059, Warsaw

52-229

Local Institution - 0070, Wroclaw

022328

Local Institution - 0284, Sector 2

0002

Local Institution - 0264, Pretoria

436-707

Local Institution - 0136, Seongnam-si

06351

Local Institution - 0133, Gangnam-gu

05505

Local Institution - 0132, Seoul

06591

Local Institution - 0135, Seoul

08035

Local Institution - 0066, Barcelona

08916

Local Institution - 0067, Barcelona

TS4 3BW

Local Institution - 0266, Middlesbrough

SW3 6JJ

Local Institution - 0098, London

SO16 0YD

Local Institution - 0099, Southampton

LE1 5WW

Local Institution - 0118, Leicester

B4 6DHH

Local Institution - 0265, Birmingham

CB2 2QQ

Local Institution - 0051, Cambridgeshire

EH4 2XU

Local Institution - 0109, Edinburgh

N18 1QX

Local Institution - 0097, London

SE1 9RT

Local Institution - 0050, London

SM2 5PT

Local Institution - 0119, Surrey

Sponsors
All Listed Sponsors
collaborator

Ono Pharmaceutical Co. Ltd

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY