Efficacy of VHM After Treatment Interruption in Subjects Initiating ART During Acute HIV Infection

Vorinostat (suberoylanilide hydroxamic acid) inhibits histone deacetylases class I and II. Vorinostat is supplied as 100mg capsules and will be administered at 400mg/ day in 2 week cycles beginning at week 0 for 10 weeks - 42 doses.

Hydroxychloroquine is supplied as 200mg tablets and will be administered at week 0 for 10 weeks

Maraviroc will be administered at 150 to 600mg/ml twice daily depending on the subject's ART regimen at week 0 for 10 weeks

NRTI. Tenofovir will be administered at 300mg 1 X day at week 0 for 10 weeks

NRTI. Emtricitabine will be administered at 200mg 1 X day at week 0 for 10 weeks

NNRTI. Efavirenz will be administered at 600 mg 1 X day at week 0 for 10 weeks

Protease Inhibitor. Darunavir will be administered at a dose of 900mg 1 X day for subjects on NNRTI based ART beginning at week 8 until week 10