Ponatinib in Participants With Resistant Chronic Phase Chronic Myeloid Leukemia (CP-CML) to Characterize the Efficacy and Safety of a Range of Doses

PHASE2CompletedINTERVENTIONAL
Enrollment

283

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

April 14, 2020

Study Completion Date

April 23, 2025

Conditions
Myeloid Leukemia, Chronic, Chronic Phase
Interventions
DRUG

Ponatinib

Tablet, taken orally once daily.

Trial Locations (86)

100

National Taiwan University Hospital, Taipei

852

Queen Mary Hospital, Hong Kong

2065

Royal North Shore Hospital, Saint Leonards

5000

Royal Adelaide Hospital, Adelaide

6591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

8091

University Hospital Zurich, Zurich

10065

Memorial Sloan-Kettering Cancer Center - New York, New York

NewYork-Presbyterian Weill Cornell Medical Center, New York

12820

Ustav Hematologie a Krevni Transfuze Praha, Prague

13353

Charite Universitatsmedizin Berlin, Berlin

16132

Azienda Ospedaliera Universitaria San Martino, Genova

18057

Universitatsmedizin Rostock, Rostock

19104

Abramson Cancer Center, Philadelphia

20090

Azienda Ospedaliera San Gerardo di Monza, Monza

20246

Universitatsklinikum Hamburg-Eppendorf, Hamburg

21201

University of Maryland Medical Center, Baltimore

27710

Duke University Medical Center, Durham

28006

Hospital Universitario de La Princesa, Madrid

28034

Hospital Universitario Ramon Y Cajal, Madrid

29010

Hospital Regional Universitario Carlos Haya, Málaga

30322

Emory University Winship Cancer Institute, Atlanta

31059

Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse

33076

Centre de Lutte Contre le Cancer - Institut Bergonie, Bordeaux

35010

Hospital Universitario de Gran Canaria Doctor Nergrin, Las Palmas de Gran Canaria

37134

"AOUI - Ospedale Policlinico Giambattista Rossi di Borgo Roma", Verona

44093

Centre Hospitalier Universitaire de Nantes Hotel Dieu, Nantes

44195

Cleveland Clinic Taussig Cancer Institute Main Campus, Cleveland

45147

Universitaetsklinikum Essen, Essen

46010

Hospital Clinico Universitario de Valencia, Valencia

46237

Indiana Blood & Marrow Transplantation, Indianapolis

48109

Michigan Medicine, Ann Arbor

48201

Barbara Ann Karmanos Cancer Institute, Detroit

49933

Center Hospitalier Universitaire d'Angers, Angers

52074

Uniklinik RWTH Aachen, Aachen

54511

Centre Hospitalier Universitaire de Nancy Hopital de Brabois, Vandœuvre-lès-Nancy

55455

University of Minnesota Medical School, Minneapolis

59037

Centre Hospitalier Regional Universitaire de Lille, Lille

61100

Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro

65124

Azienda Sanitaria Locale di Pescara Ospedale Civile Dello Spirito Santo, Pescara

68169

Universitaetsklinikum Heidelberg, Mannheim

68198

University of Nebraska Medical Center, Omaha

77030

MD Anderson Cancer Center, Houston

84112

University of Utah Huntsman Cancer Institute, Salt Lake City

86021

Centre Hospitalier Universitaire de Poitiers, Poitiers

89081

Universitatsklinikum Ulm, Ulm

95124

Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania

97239

Oregon Health and Science University, Portland

111123

GBUZ Moscow Clinical Scientific Center DZM, Moscow

125167

Russian Academy of Medical Science, Moscow

169856

Singapore General Hospital, Singapore

191024

FGU Russian Scientific Research Institute of Hematology and Transfusiology, Saint Petersburg

197341

Almazov Federal North-West Medical Research Centre of Department of Health of Russian Federation, Saint Petersburg

344022

Rostov State Medical University, Rostov-on-Don

355018

Saratov State Medical University, Saratov

443099

Samara State Medical University, Samara

454076

Chelyabinsk Regional Clinical Hospital, Chelyabinsk

650066

Kemerovo Regional Clinical Hospital, Kemerovo

2540364

Centro de Investigaciones Clinicas Vina del Mar, Viña del Mar

7500922

Hospital del Salvador, Providencia

07601

Hackensack University Medical Center, Hackensack

C1114AAN

Fundaleu, Ciudad Autonoma de Buenos Aires

C1221ADC

Hospital General de Agudo Jose Maria Ramos Mejia, Ciudad Autonoma de Buenos Aires

B1900AXI

Hospital Italiano La Plata, La Plata

M5G 2M9

Princess Margaret Hospital - Toronto, Toronto

H3T 1E2

Jewish General Hospital, Montreal

S4T 7T1

Saskatchewan Cancer Agency, Regina

772 00

Fakultni Nemocnice Olomouc, Olomouc

DK-8000

Aarhus University Hospital, Aarhus C

06202

Centre Hospitalier Universitaire de Nice Hopital l'Archet, Nice

07747

Universitatsklinikum Jena, Jena

00161

Sapienza Universita Di Roma, Roma

30-510

Malopolskie Centrum Medyczne, Krakow

50-367

Samodzielny Publiczny Szpital Kliniczny Nr 1 we Wroclawiu, Wroclaw

02-776

Instytut Hematologii i Transfuzjologii, Warsaw

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

93-510

Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz

1090-023

Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisbon

4200-319

Centro Hospitalar Sao Joao, Porto

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

751 85

Akademiska Sjukhuset, Uppsala

L7 8XP

Royal Liverpool University Hospital NHS Trust, Liverpool

SE5 9RS

King's College Hospital NHS Foundation Trust, London

W12 0NN

Imperial College Healthcare NHS Trust, London

NG5 1PB

Nottingham City Hospital NHS Trust, Nottingham

OX3 7LE

Churchill Hospital, Oxford

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Takeda

INDUSTRY