450
Participants
Start Date
May 10, 2016
Primary Completion Date
January 26, 2023
Study Completion Date
July 14, 2026
Brachytherapy
Undergo brachytherapy
Cisplatin
Given IV
External Beam Radiation Therapy
Undergo EBRT
Intensity-Modulated Radiation Therapy
Undergo IMRT
Laboratory Biomarker Analysis
Correlative studies
Radiation Therapy
Undergo conventional RT
Triapine
Given IV
Mount Sinai Chelsea, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Maimonides Medical Center, Brooklyn
Saint Peter's Health Partners, Albany
Women's Cancer Care Associates LLC, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
Highland Hospital, Rochester
University of Rochester, Rochester
UPMC-Heritage Valley Health System Beaver, Beaver
UPMC Hillman Cancer Center in Coraopolis, Moon Township
UPMC-Magee Womens Hospital, Pittsburgh
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
UPMC-Shadyside Hospital, Pittsburgh
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg
Adams Cancer Center, Gettysburg
WellSpan Medical Oncology and Hematology, Hanover
WellSpan Health-York Cancer Center, York
WellSpan Health-York Hospital, York
Ephrata Cancer Center, Ephrata
Northeast Radiation Oncology Center, Dunmore
Jefferson Abington Hospital, Abington
Asplundh Cancer Pavilion, Willow Grove
Lankenau Medical Center, Wynnewood
Thomas Jefferson University Hospital, Philadelphia
Christiana Care Health System-Concord Health Center, Chadds Ford
Reading Hospital, West Reading
Delaware Clinical and Laboratory Physicians PA, Newark
Helen F Graham Cancer Center, Newark
Medical Oncology Hematology Consultants PA, Newark
Christiana Care Health System-Christiana Hospital, Newark
Beebe Medical Center, Lewes
Greater Baltimore Medical Center, Baltimore
Edwards Comprehensive Cancer Center, Huntington
Wheeling Hospital/Schiffler Cancer Center, Wheeling
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
Novant Health Presbyterian Medical Center, Charlotte
Spartanburg Medical Center, Spartanburg
Saint Francis Hospital, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Saint Francis Cancer Center, Greenville
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Augusta University Medical Center, Augusta
Memorial Health University Medical Center, Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
University of Florida Health Science Center - Gainesville, Gainesville
Moffitt Cancer Center, Tampa
Lakeland Regional Health Hollis Cancer Center, Lakeland
University of Alabama at Birmingham Cancer Center, Birmingham
Vanderbilt University/Ingram Cancer Center, Nashville
Memorial Hospital, Chattanooga
University of Mississippi Medical Center, Jackson
Jewish Hospital, Louisville
The James Graham Brown Cancer Center at University of Louisville, Louisville
UofL Health Medical Center Northeast, Louisville
Saint Joseph Radiation Oncology Resource Center, Lexington
Saint Joseph Hospital East, Lexington
University of Kentucky/Markey Cancer Center, Lexington
Delaware Radiation Oncology, Delaware
Grady Memorial Hospital, Delaware
Licking Memorial Hospital, Newark
Newark Radiation Oncology, Newark
Saint Ann's Hospital, Westerville
Mount Carmel East Hospital, Columbus
Riverside Methodist Hospital, Columbus
Grant Medical Center, Columbus
The Mark H Zangmeister Center, Columbus
Mount Carmel Health Center West, Columbus
Doctors Hospital, Columbus
ProMedica Flower Hospital, Sylvania
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Genesis Healthcare System Cancer Care Center, Zanesville
Geauga Hospital, Chardon
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
Case Western Reserve University, Cleveland
MetroHealth Medical Center, Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
UHHS-Chagrin Highlands Medical Center, Beachwood
Hillcrest Hospital Cancer Center, Mayfield Heights
UH Seidman Cancer Center at Saint John Medical Center, Westlake
UHHS-Westlake Medical Center, Westlake
Cleveland Clinic Foundation, Cleveland
University Hospitals Sharon Health Center, Wadsworth
Summa Health System - Akron Campus, Akron
Aultman Health Foundation, Canton
OhioHealth Mansfield Hospital, Mansfield
University of Cincinnati Cancer Center-West Chester, West Chester
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
Good Samaritan Hospital - Cincinnati, Cincinnati
Bethesda North Hospital, Cincinnati
Oncology Hematology Care Inc-Blue Ash, Cincinnati
Wayne Hospital, Greenville
Upper Valley Medical Center, Troy
Good Samaritan Hospital - Dayton, Dayton
Miami Valley Hospital, Dayton
Dayton Physician LLC - Englewood, Dayton
Miami Valley Hospital North, Dayton
Kettering Medical Center, Kettering
Miami Valley Hospital South, Centerville
Springfield Regional Medical Center, Springfield
Adena Regional Medical Center, Chillicothe
Southern Ohio Medical Center, Portsmouth
Marietta Memorial Hospital, Marietta
Blanchard Valley Hospital, Findlay
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
Sidney and Lois Eskenazi Hospital, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
Parkview Hospital Randallia, Fort Wayne
Parkview Regional Medical Center, Fort Wayne
Reid Health, Richmond
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
Henry Ford Cancer Institute-Downriver, Brownstown
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
Henry Ford West Bloomfield Hospital, West Bloomfield
Weisberg Cancer Treatment Center, Farmington Hills
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Beacon Kalamazoo, Kalamazoo
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Trinity Health Muskegon Hospital, Muskegon
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
University of Michigan Health - West, Wyoming
Corewell Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Mercy Medical Center-West Lakes, West Des Moines
Iowa Methodist Medical Center, Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
Iowa Lutheran Hospital, Des Moines
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
Mercy Hospital, Cedar Rapids
Oncology Associates at Mercy Medical Center, Cedar Rapids
Medical College of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Medical Center - Minocqua, Minocqua
Marshfield Medical Center-EC Cancer Center, Eau Claire
University of Minnesota/Masonic Cancer Center, Minneapolis
Mayo Clinic in Rochester, Rochester
Rapid City Regional Hospital, Rapid City
Billings Clinic Cancer Center, Billings
Saint Vincent Healthcare, Billings
Benefis Sletten Cancer Institute, Great Falls
Great Falls Clinic, Great Falls
Saint James Community Hospital and Cancer Treatment Center, Butte
Bozeman Health Deaconess Hospital, Bozeman
Community Medical Center, Missoula
Logan Health Medical Center, Kalispell
Northwestern Medicine Cancer Center Delnor, Geneva
Loyola University Medical Center, Maywood
Northwestern Medicine Cancer Center Warrenville, Warrenville
Northwestern University, Chicago
John H Stroger Jr Hospital of Cook County, Chicago
Rush University Medical Center, Chicago
Illinois CancerCare-Ottawa Clinic, Ottawa
Radiation Oncology of Northern Illinois, Ottawa
Illinois CancerCare-Peru, Peru
Valley Radiation Oncology, Peru
Illinois CancerCare-Princeton, Princeton
Western Illinois Cancer Treatment Center, Galesburg
OSF Saint Francis Radiation Oncology at Pekin, Pekin
Illinois CancerCare-Peoria, Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria
Methodist Medical Center of Illinois, Peoria
OSF Saint Francis Medical Center, Peoria
OSF Saint Joseph Medical Center, Bloomington
Carle Cancer Center, Urbana
Southwest Illinois Health Services LLP, Swansea
Cancer Care Center of O'Fallon, O'Fallon
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Central Illinois Hematology Oncology Center, Springfield
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
SSM Health Good Samaritan, Mount Vernon
Memorial Hospital of Carbondale, Carbondale
Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin
Missouri Baptist Medical Center, St Louis
Mercy Hospital Saint Louis, St Louis
Mercy Cancer Center - Cape Girardeau, Cape Girardeau
Saint Francis Medical Center, Cape Girardeau
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
North Kansas City Hospital, Kansas City
The University of Kansas Cancer Center-South, Kansas City
University of Kansas Cancer Center - North, Kansas City
Freeman Health System, Joplin
MU Health Care Goldschmidt Cancer Center, Jefferson City
Mercy Clinic-Rolla-Cancer and Hematology, Rolla
Phelps Health Delbert Day Cancer Institute, Rolla
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
The University of Kansas Cancer Center - Olathe, Olathe
University of Kansas Cancer Center, Kansas City
University of Kansas Cancer Center-Overland Park, Overland Park
University of Kansas Health System Saint Francis Campus, Topeka
Mercy Hospital Pittsburg, Pittsburg
Salina Regional Health Center, Salina
Saint Rose Ambulatory and Surgery Center, Great Bend
HaysMed, Hays
Saint Catherine Hospital, Garden City
Midlands Community Hospital, Papillion
Nebraska Methodist Hospital, Omaha
Alegent Health Immanuel Medical Center, Omaha
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
Creighton University Medical Center, Omaha
University of Nebraska Medical Center, Omaha
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island
CHI Health Good Samaritan, Kearney
East Jefferson General Hospital, Metairie
University Medical Center New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
CHI Saint Vincent Cancer Center Hot Springs, Hot Springs
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
Parkland Memorial Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Houston Methodist Hospital, Houston
Memorial Hermann Texas Medical Center, Houston
Methodist Willowbrook Hospital, Houston
Houston Methodist The Woodlands Hospital, The Woodlands
Houston Methodist Sugar Land Hospital, Sugar Land
Saint Joseph Regional Cancer Center, Bryan
UCHealth University of Colorado Hospital, Aurora
AdventHealth Littleton, Littleton
AdventHealth Porter, Denver
Saint Anthony Hospital, Lakewood
Rocky Mountain Cancer Centers-Thornton, Thornton
Longmont United Hospital, Longmont
Penrose-Saint Francis Healthcare, Colorado Springs
Rocky Mountain Cancer Centers-Penrose, Colorado Springs
Saint Mary Corwin Medical Center, Pueblo
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
Saint Luke's Cancer Institute - Fruitland, Fruitland
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Cancer Institute - Boise, Boise
Kootenai Clinic Cancer Services - Post Falls, Post Falls
South Jordan Health Center, South Jordan
Utah Cancer Specialists-Salt Lake City, Salt Lake City
Intermountain Medical Center, Murray
Huntsman Cancer Institute/University of Utah, Salt Lake City
LDS Hospital, Salt Lake City
Logan Regional Hospital, Logan
McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center, Provo
Sandra L Maxwell Cancer Center, Cedar City
Saint George Regional Medical Center, St. George
Banner University Medical Center - Tucson, Tucson
University of Arizona Cancer Center-North Campus, Tucson
Southwest Gynecologic Oncology Associates Inc, Albuquerque
University of New Mexico Cancer Center, Albuquerque
Memorial Medical Center-Las Cruces, Las Cruces
Radiation Oncology Centers of Nevada Central, Las Vegas
Women's Cancer Center of Nevada, Las Vegas
Center of Hope at Renown Medical Center, Reno
Renown Regional Medical Center, Reno
Los Angeles General Medical Center, Los Angeles
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
UC San Diego Moores Cancer Center, La Jolla
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Kaiser Permanente-Fresno, Fresno
Kaiser Permanente-Redwood City, Redwood City
Kaiser Permanente Cancer Treatment Center, South San Francisco
Kaiser Permanente-South San Francisco, South San Francisco
Kaiser Permanente-San Francisco, San Francisco
Kaiser Permanente-Deer Valley Medical Center, Antioch
Kaiser Permanente-Fremont, Fremont
Kaiser Permanente San Leandro, San Leandro
Kaiser Permanente-Vallejo, Vallejo
Kaiser Permanente-Walnut Creek, Walnut Creek
Kaiser Permanente Oakland-Broadway, Oakland
Kaiser Permanente-Oakland, Oakland
Kaiser Permanente-Richmond, Richmond
Kaiser Permanente-San Rafael, San Rafael
Kaiser San Rafael-Gallinas, San Rafael
Rohnert Park Cancer Center, Rohnert Park
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Kaiser Permanente-Santa Teresa-San Jose, San Jose
Kaiser Permanente-Stockton, Stockton
Kaiser Permanente-Modesto, Modesto
Kaiser Permanente-Santa Rosa, Santa Rosa
Kaiser Permanente-Roseville, Roseville
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova
The Permanente Medical Group-Roseville Radiation Oncology, Roseville
Kaiser Permanente Medical Center-Vacaville, Vacaville
University of California Davis Comprehensive Cancer Center, Sacramento
Kaiser Permanente-South Sacramento, Sacramento
South Sacramento Cancer Center, Sacramento
Kaiser Permanente Sacramento Medical Center, Sacramento
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee
Pali Momi Medical Center, ‘Aiea
Queen's Cancer Center - Pearlridge, ‘Aiea
The Cancer Center of Hawaii-Pali Momi, ‘Aiea
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu
Island Urology, Honolulu
Queen's Medical Center, Honolulu
Straub Clinic and Hospital, Honolulu
University of Hawaii Cancer Center, Honolulu
Hawaii Cancer Care Inc-Liliha, Honolulu
Kuakini Medical Center, Honolulu
Queen's Cancer Center - Kuakini, Honolulu
The Cancer Center of Hawaii-Liliha, Honolulu
Kaiser Permanente Moanalua Medical Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Clackamas Radiation Oncology Center, Clackamas
Legacy Mount Hood Medical Center, Gresham
Legacy Meridian Park Hospital, Tualatin
Legacy Good Samaritan Hospital and Medical Center, Portland
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Oregon Health and Science University, Portland
Bay Area Hospital, Coos Bay
Saint Charles Health System, Bend
MultiCare Auburn Medical Center, Auburn
Virginia Mason Federal Way Medical Center, Federal Way
Overlake Medical Center, Bellevue
Swedish Cancer Institute-Issaquah, Issaquah
Virginia Mason Medical Center, Seattle
Fred Hutchinson Cancer Center, Seattle
Kaiser Permanente Washington, Seattle
Swedish Medical Center-First Hill, Seattle
Highline Medical Center-Main Campus, Burien
Providence Regional Cancer Partnership, Everett
PeaceHealth Saint Joseph Medical Center, Bellingham
Tacoma/Valley Radiation Oncology Centers-Gig Harbor, Gig Harbor
MultiCare Gig Harbor Medical Park, Gig Harbor
MultiCare Good Samaritan Hospital, Puyallup
Tacoma/Valley Radiation Oncology Centers-Puyallup, Puyallup
Saint Michael Cancer Center, Silverdale
MultiCare Tacoma General Hospital, Tacoma
Northwest Medical Specialties PLLC, Tacoma
Tacoma/Valley Radiation Oncology Centers-Saint Joe's, Tacoma
Providence Regional Cancer System-Lacey, Lacey
Anchorage Associates in Radiation Medicine, Anchorage
Providence Regional Cancer System-Aberdeen, Aberdeen
Providence Regional Cancer System-Centralia, Centralia
PeaceHealth Saint John Medical Center, Longview
PeaceHealth Southwest Medical Center, Vancouver
Legacy Salmon Creek Hospital, Vancouver
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
Providence Saint Mary Regional Cancer Center, Walla Walla
Alaska Breast Care and Surgery LLC, Anchorage
Alaska Oncology and Hematology LLC, Anchorage
Alaska Women's Cancer Care, Anchorage
Anchorage Oncology Centre, Anchorage
Katmai Oncology Group, Anchorage
Providence Alaska Medical Center, Anchorage
Fairbanks Memorial Hospital, Fairbanks
Hartford Hospital, Hartford
Mayo Clinic in Florida, Jacksonville
Methodist West Hospital, West Des Moines
Walter Reed National Military Medical Center, Bethesda
Cooper Hospital University Medical Center, Camden
Virtua Memorial, Mount Holly
Cooper CyberKnife Center, Mount Laurel
Rutgers Cancer Institute of New Jersey, New Brunswick
Rutgers New Jersey Medical School, Newark
Robert Wood Johnson University Hospital Somerset, Somerville
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township
Virtua Voorhees, Voorhees Township
Atrium Medical Center-Middletown Regional Hospital, Franklin
Women and Infants Hospital, Providence
Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto
San Juan Community Oncology Group, San Juan
Centro Comprensivo de Cancer de UPR, San Juan
San Juan City Hospital, San Juan
Collaborators (1)
NRG Oncology
OTHER
National Cancer Institute (NCI)
NIH