Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

450

Participants

Timeline

Start Date

May 10, 2016

Primary Completion Date

January 26, 2023

Study Completion Date

July 14, 2026

Conditions
Advanced Vaginal AdenocarcinomaAdvanced Vaginal Adenosquamous CarcinomaAdvanced Vaginal Squamous Cell CarcinomaCervical AdenocarcinomaCervical Adenosquamous CarcinomaCervical Squamous Cell CarcinomaStage IB2 Cervical Cancer AJCC v6 and v7Stage II Cervical Cancer AJCC v7Stage II Vaginal Cancer AJCC v6 and v7Stage IIA Cervical Cancer AJCC v7Stage IIB Cervical Cancer AJCC v6 and v7Stage III Vaginal Cancer AJCC v6 and v7Stage IIIB Cervical Cancer AJCC v6 and v7Stage IV Vaginal Cancer AJCC v6 and v7Stage IVA Cervical Cancer AJCC v6 and v7Stage IVA Vaginal Cancer AJCC v6 and v7Unresectable Vaginal CarcinomaVaginal AdenocarcinomaVaginal Adenosquamous CarcinomaVaginal CarcinomaVaginal Squamous Cell Carcinoma, Not Otherwise Specified
Interventions
RADIATION

Brachytherapy

Undergo brachytherapy

DRUG

Cisplatin

Given IV

RADIATION

External Beam Radiation Therapy

Undergo EBRT

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

OTHER

Laboratory Biomarker Analysis

Correlative studies

RADIATION

Radiation Therapy

Undergo conventional RT

DRUG

Triapine

Given IV

Trial Locations (382)

10011

Mount Sinai Chelsea, New York

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

11219

Maimonides Medical Center, Brooklyn

12208

Saint Peter's Health Partners, Albany

Women's Cancer Care Associates LLC, Albany

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

15009

UPMC-Heritage Valley Health System Beaver, Beaver

15108

UPMC Hillman Cancer Center in Coraopolis, Moon Township

15213

UPMC-Magee Womens Hospital, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

UPMC-Shadyside Hospital, Pittsburgh

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

17325

Adams Cancer Center, Gettysburg

17331

WellSpan Medical Oncology and Hematology, Hanover

17403

WellSpan Health-York Cancer Center, York

WellSpan Health-York Hospital, York

17522

Ephrata Cancer Center, Ephrata

18512

Northeast Radiation Oncology Center, Dunmore

19001

Jefferson Abington Hospital, Abington

19090

Asplundh Cancer Pavilion, Willow Grove

19096

Lankenau Medical Center, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19611

Reading Hospital, West Reading

19713

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19958

Beebe Medical Center, Lewes

21204

Greater Baltimore Medical Center, Baltimore

25701

Edwards Comprehensive Cancer Center, Huntington

26003

Wheeling Hospital/Schiffler Cancer Center, Wheeling

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

28204

Novant Health Presbyterian Medical Center, Charlotte

29303

Spartanburg Medical Center, Spartanburg

29601

Saint Francis Hospital, Greenville

29605

Prisma Health Cancer Institute - Faris, Greenville

29607

Saint Francis Cancer Center, Greenville

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

30912

Augusta University Medical Center, Augusta

31404

Memorial Health University Medical Center, Savannah

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

32610

University of Florida Health Science Center - Gainesville, Gainesville

33612

Moffitt Cancer Center, Tampa

33805

Lakeland Regional Health Hollis Cancer Center, Lakeland

35233

University of Alabama at Birmingham Cancer Center, Birmingham

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37404

Memorial Hospital, Chattanooga

39216

University of Mississippi Medical Center, Jackson

40202

Jewish Hospital, Louisville

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

UofL Health Medical Center Northeast, Louisville

40504

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40536

University of Kentucky/Markey Cancer Center, Lexington

43015

Delaware Radiation Oncology, Delaware

Grady Memorial Hospital, Delaware

43055

Licking Memorial Hospital, Newark

Newark Radiation Oncology, Newark

43081

Saint Ann's Hospital, Westerville

43213

Mount Carmel East Hospital, Columbus

43214

Riverside Methodist Hospital, Columbus

43215

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43560

ProMedica Flower Hospital, Sylvania

43606

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44024

Geauga Hospital, Chardon

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44145

UH Seidman Cancer Center at Saint John Medical Center, Westlake

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44281

University Hospitals Sharon Health Center, Wadsworth

44304

Summa Health System - Akron Campus, Akron

44710

Aultman Health Foundation, Canton

44903

OhioHealth Mansfield Hospital, Mansfield

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

Oncology Hematology Care Inc-Blue Ash, Cincinnati

45331

Wayne Hospital, Greenville

45373

Upper Valley Medical Center, Troy

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Miami Valley Hospital South, Centerville

45504

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45750

Marietta Memorial Hospital, Marietta

45840

Blanchard Valley Hospital, Findlay

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

Sidney and Lois Eskenazi Hospital, Indianapolis

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

46805

Parkview Hospital Randallia, Fort Wayne

46845

Parkview Regional Medical Center, Fort Wayne

47374

Reid Health, Richmond

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

Weisberg Cancer Treatment Center, Farmington Hills

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49048

Beacon Kalamazoo, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

52403

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

57701

Rapid City Regional Hospital, Rapid City

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60153

Loyola University Medical Center, Maywood

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

Rush University Medical Center, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Radiation Oncology of Northern Illinois, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Western Illinois Cancer Treatment Center, Galesburg

61554

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

OSF Saint Joseph Medical Center, Bloomington

61801

Carle Cancer Center, Urbana

62226

Southwest Illinois Health Services LLP, Swansea

62269

Cancer Care Center of O'Fallon, O'Fallon

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Central Illinois Hematology Oncology Center, Springfield

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62864

SSM Health Good Samaritan, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

63011

Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

Saint Francis Medical Center, Cape Girardeau

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

North Kansas City Hospital, Kansas City

64131

The University of Kansas Cancer Center-South, Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

64804

Freeman Health System, Joplin

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

Phelps Health Delbert Day Cancer Institute, Rolla

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66061

The University of Kansas Cancer Center - Olathe, Olathe

66160

University of Kansas Cancer Center, Kansas City

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66606

University of Kansas Health System Saint Francis Campus, Topeka

66762

Mercy Hospital Pittsburg, Pittsburg

67401

Salina Regional Health Center, Salina

67530

Saint Rose Ambulatory and Surgery Center, Great Bend

67601

HaysMed, Hays

67846

Saint Catherine Hospital, Garden City

68046

Midlands Community Hospital, Papillion

68114

Nebraska Methodist Hospital, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68198

University of Nebraska Medical Center, Omaha

68803

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island

68847

CHI Health Good Samaritan, Kearney

70006

East Jefferson General Hospital, Metairie

70112

University Medical Center New Orleans, New Orleans

70121

Ochsner Medical Center Jefferson, New Orleans

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

Houston Methodist Hospital, Houston

Memorial Hermann Texas Medical Center, Houston

77070

Methodist Willowbrook Hospital, Houston

77385

Houston Methodist The Woodlands Hospital, The Woodlands

77479

Houston Methodist Sugar Land Hospital, Sugar Land

77802

Saint Joseph Regional Cancer Center, Bryan

80045

UCHealth University of Colorado Hospital, Aurora

80122

AdventHealth Littleton, Littleton

80210

AdventHealth Porter, Denver

80228

Saint Anthony Hospital, Lakewood

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80501

Longmont United Hospital, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

84009

South Jordan Health Center, South Jordan

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84143

LDS Hospital, Salt Lake City

84321

Logan Regional Hospital, Logan

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center, Provo

84720

Sandra L Maxwell Cancer Center, Cedar City

84770

Saint George Regional Medical Center, St. George

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

87106

Southwest Gynecologic Oncology Associates Inc, Albuquerque

University of New Mexico Cancer Center, Albuquerque

88011

Memorial Medical Center-Las Cruces, Las Cruces

89106

Radiation Oncology Centers of Nevada Central, Las Vegas

Women's Cancer Center of Nevada, Las Vegas

89502

Center of Hope at Renown Medical Center, Reno

Renown Regional Medical Center, Reno

90033

Los Angeles General Medical Center, Los Angeles

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92093

UC San Diego Moores Cancer Center, La Jolla

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93720

Kaiser Permanente-Fresno, Fresno

94063

Kaiser Permanente-Redwood City, Redwood City

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

Kaiser Permanente-Fremont, Fremont

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente Oakland-Broadway, Oakland

Kaiser Permanente-Oakland, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser Permanente-San Rafael, San Rafael

Kaiser San Rafael-Gallinas, San Rafael

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

Kaiser Permanente-Stockton, Stockton

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

Kaiser Permanente-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95688

Kaiser Permanente Medical Center-Vacaville, Vacaville

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95823

Kaiser Permanente-South Sacramento, Sacramento

South Sacramento Cancer Center, Sacramento

95825

Kaiser Permanente Sacramento Medical Center, Sacramento

96161

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee

96701

Pali Momi Medical Center, ‘Aiea

Queen's Cancer Center - Pearlridge, ‘Aiea

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Island Urology, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Hawaii Cancer Care Inc-Liliha, Honolulu

Kuakini Medical Center, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

97030

Legacy Mount Hood Medical Center, Gresham

97062

Legacy Meridian Park Hospital, Tualatin

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97239

Oregon Health and Science University, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

98001

MultiCare Auburn Medical Center, Auburn

98002

Virginia Mason Federal Way Medical Center, Federal Way

98004

Overlake Medical Center, Bellevue

98029

Swedish Cancer Institute-Issaquah, Issaquah

98101

Virginia Mason Medical Center, Seattle

98109

Fred Hutchinson Cancer Center, Seattle

98112

Kaiser Permanente Washington, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98166

Highline Medical Center-Main Campus, Burien

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98332

Tacoma/Valley Radiation Oncology Centers-Gig Harbor, Gig Harbor

98335

MultiCare Gig Harbor Medical Park, Gig Harbor

98372

MultiCare Good Samaritan Hospital, Puyallup

Tacoma/Valley Radiation Oncology Centers-Puyallup, Puyallup

98383

Saint Michael Cancer Center, Silverdale

98405

MultiCare Tacoma General Hospital, Tacoma

Northwest Medical Specialties PLLC, Tacoma

Tacoma/Valley Radiation Oncology Centers-Saint Joe's, Tacoma

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

98686

Legacy Salmon Creek Hospital, Vancouver

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

99701

Fairbanks Memorial Hospital, Fairbanks

06102

Hartford Hospital, Hartford

32224-9980

Mayo Clinic in Florida, Jacksonville

50266-7700

Methodist West Hospital, West Des Moines

20889-5600

Walter Reed National Military Medical Center, Bethesda

08103

Cooper Hospital University Medical Center, Camden

08060

Virtua Memorial, Mount Holly

08054

Cooper CyberKnife Center, Mount Laurel

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

07101

Rutgers New Jersey Medical School, Newark

08876

Robert Wood Johnson University Hospital Somerset, Somerville

08043

MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township

Virtua Voorhees, Voorhees Township

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

02905

Women and Infants Hospital, Providence

M4N 3M5

Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto

00917

San Juan Community Oncology Group, San Juan

00927

Centro Comprensivo de Cancer de UPR, San Juan

00936

San Juan City Hospital, San Juan

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH