212
Participants
Start Date
November 20, 2015
Primary Completion Date
January 15, 2018
Study Completion Date
February 4, 2019
Placebo
Participants will receive matching placebo subcutaneous (SC) injections once weekly for 48 weeks of double-blind treatment.
Tocilizumab
Participants will receive 162 mg SC tocilizumab once weekly for 48 weeks of double-blind treatment. The same regimen will be given to all eligible participants for 48 weeks of open-label treatment.
National Institute of Rheumatology and Physiology, Budapest
MHAT St.Ivan Rilski; Rheumtology Department, Sofia
MHAT Sv.Ivan Rilski; Clinic of Rheumatology, Sofia
Bispebjerg Hospital, Dermatologisk afdeling, København NV
UZ Leuven Gasthuisberg, Leuven
Centro de Investigaciones Reumatologicas Tucuman, San Miguel de Tucumán
MHAT Kaspela; Rheumatology, Plovdiv
MHAT-Plovdiv AD; Reumatology Department, Plovdiv
Universitätsspital Basel; Rheumatologische Poliklinik, Basel
Pécsi Tudományegyetem Klinikai Központ: Immunológiai és Reumatológiai Klinika, Pécs
Universitätsspital Zürich; Klinik für Rheumatologie, Zurich
Aarhus Universitetshospital Skejby, Hud- og Kønssygdomme, Aarhus N
UZ Gent, Ghent
Thomas Jefferson Uni ; Division of Rheumatology, Philadelphia
Clinical Research Center of Reading, Wyomissing
Georgetown Uni. Hosp.; Rheumatology, Immunology and Allergy Dept., Washington D.C.
Ospedale Maggiore Policlinico; Unità Operativa Complessa di Allergologia e Immunologia Clinica, Milan
Hospital General Universitario Gregorio Marañon; Servicio de Reumatología, Madrid
Joint & Muscle Research Institute, Charlotte
Millenium Research, Ormond Beach
Rheumatology Assoc. of S. Florida - Clinical Research Center, Boca Raton
West Tennessee Research Institute, Jackson
Unidad De Enfermedades; Cronico Degenerativas, SC., México
West Michigan Rheumatology, PLLC, Grand Rapids
Ospedale Careggi Villa Monnatessa ; Sezione Di Reumatologia, Florence
Hopital Claude Huriez; Internal Medicine, Lille
Kerckhoff-Klinik; Rheumatologie&klin.Immunologie, Bad Nauheim
Universitätsklinikum Tübingen Medizinische UNI-Klinik und Poliklinik Abt. Innere Medizin II, Tübingen
Arthritis and Rheumatology; Center of Oklahoma PLLC, Oklahoma City
Metroplex Clinical Research, Dallas
Policlinico Universitario-II Università di Napoli; Reumatologia, Napoli
Klinikum der Universitat Munchen; Bereich Pettenkoferstr; Rheumaeinheit der medizinischen Klinik IV, München
Univ of Calif., Los Angeles; Rheumatology, Los Angeles
Arthritis Associates of Southern California, Los Angeles
TriWest Research Associates, LLC, El Cajon
St. Joseph's Heritage Healthcare, Fullerton
Asklepios Kllinikum Bad Abbach; Klinik für Rheumatologie und Klinische Immunologie, Bad Abbach
Spitalul Judetean Cluj; Sectia de Reumatologie, Cluj-Napoca
Boston Univ Med Center - AC, Boston
University of Michigan, Ann Arbor
Organizacion Medica de Investigacion, Buenos Aires
Hospital Britanico; Haematology, Buenos Aires
Sanatorio Parque S.A., Rosario, Santa FE
St. Paul's Hospital University of British Colambia Division of Hematology, Vancouver
Mount Sinai Hospital; Rebecca Macdonald Centre For Arthritis & Autoimmune Disease, Toronto
Universitätsklinikum Dresden; Technische Universität Dresden; Rheumatologie, Innere Medizin III, Dresden
Laiko General Hospital; Dept. of Pathophysiology-Uni of Athens, Athens
University Hospital of Patras; Rheumatology, Pátrai
Uni ' Cattolica Del Sacro Cuore; Facoltà Di Medicina E Chirurgia A.Gemelli-Clinica Reumatologica, Rome
Gunma University Hospital, Gunma
Sapporo Medical University Hospital, Hokkaido
Hokkaido University Hospital, Hokkaido
Kanazawa University Hospital, Ishikawa
St. Marianna University School of Medicine Hospital, Kanagawa
Hospital of the University of Occupational and Environmental Health,Japan, Kitakyushu-shi
Kumamoto University Hospital, Kumamoto
Tohoku University Hospital, Miyagi
Osaka University Hospital, Osaka
Nippon Medical School Hospital, Tokyo
The University of Tokyo Hospital, Tokyo
Klaipeda University Hospital; Department of Rheumatology, Klaipėda
Vilnius University Hospital Santariskiu Clinic Public Insti, Vilnius
Instituto Nacional de Ciencias Médicas Y de La Nutricion Zubirán, Mexico City
Cliditer SA de CV, Miexico City
Academisch Ziekenhuis Leiden; Dept of Rheumatology, Leiden
Szpital Uniwersytecki; nr 2 im. Dr J. Biziela; Klinika Reumatologii i Ukladowych Chorob, Bydgoszcz
Uniwersyteckie Centrum Kliniczne; Klinika Chorob Wewnetrznych, Chorob Tkanki Łacznej i Geriatrii, Gdansk
Gornoslaskie Centrum Medyczne, Katowice
Szpital Specjalistyczny im Jozefa Dietla; Centrum Reumatologii, Immunologii i Rehabilitacji, I Oddzi, Krakow
SPSK NR 4; Reumatologii i Ukladowych Chorob Tkanki, Lublin
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. Eleonory Reicher, Warsaw
Hospital Garcia de Orta; Servico de Reumatologia, Almada
Hospital Prof. Dr. Fernando Fonseca; Medicina IV, Amadora
Puerto Rico Clinical & Translational Research Consortium, San Juan
Cantacuzino Hospital; Department of Internal Medicine and Rheumatology, Bucharest
Hospital de la Santa Creu i Sant Pau; Servicio de Medicina Interna/Reumatologia, Barcelona
Hospital Universitario Vall d'Hebron; Servicio de Medicina Interna, Barcelona
Queen Elizabeth Hospital; Rheumatology Dept., Birmingham
Western General Hospital, Edinburgh
Chapel Allerton Hospital; Leeds Institution of Rheumatology Medicine, Leeds
Uni Hospital Aintree; Academic Rheumatology Unit, Liverpool
Royal Free Hospital; Department of Rheumatology, London
Freeman Hospital; Musculoskeletal Unit, Newcastle upon Tyne
Hoffmann-La Roche
INDUSTRY