Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma

PHASE2CompletedINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

October 12, 2015

Primary Completion Date

June 30, 2017

Study Completion Date

September 30, 2021

Conditions
Pleuropulmonary BlastomaRecurrent Malignant Peripheral Nerve Sheath TumorRecurrent NeuroblastomaRecurrent RhabdomyosarcomaRecurrent Synovial SarcomaWilms Tumor
Interventions
OTHER

Laboratory Biomarker Analysis

Correlative studies

BIOLOGICAL

Lorvotuzumab Mertansine

Given IV

OTHER

Pharmacological Study

Correlative studies

Trial Locations (69)

10029

Mount Sinai Hospital, New York

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

19803

Alfred I duPont Hospital for Children, Wilmington

20010

Children's National Medical Center, Washington D.C.

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

23507

Children's Hospital of The King's Daughters, Norfolk

26506

West Virginia University Healthcare, Morgantown

29203

Prisma Health Richland Hospital, Columbia

30322

Children's Healthcare of Atlanta - Egleston, Atlanta

32803

AdventHealth Orlando, Orlando

33155

Nicklaus Children's Hospital, Miami

33701

Johns Hopkins All Children's Hospital, St. Petersburg

33908

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

Children's Hospital of Alabama, Birmingham

37232

Vanderbilt University/Ingram Cancer Center, Nashville

38105

St. Jude Children's Research Hospital, Memphis

39216

University of Mississippi Medical Center, Jackson

40536

University of Kentucky/Markey Cancer Center, Lexington

43205

Nationwide Children's Hospital, Columbus

44106

Rainbow Babies and Childrens Hospital, Cleveland

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

Riley Hospital for Children, Indianapolis

46260

Saint Vincent Hospital and Health Care Center, Indianapolis

48109

C S Mott Children's Hospital, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Ascension Saint John Hospital, Detroit

49503

Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids

53226

Children's Hospital of Wisconsin, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

Mayo Clinic, Rochester

58122

Sanford Broadway Medical Center, Fargo

60611

Lurie Children's Hospital-Chicago, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61637

Saint Jude Midwest Affiliate, Peoria

63110

Washington University School of Medicine, St Louis

63141

Mercy Hospital Saint Louis, St Louis

70121

Ochsner Medical Center Jefferson, New Orleans

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

Cook Children's Medical Center, Fort Worth

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

78723

Dell Children's Medical Center of Central Texas, Austin

80045

Children's Hospital Colorado, Aurora

83712

Saint Luke's Mountain States Tumor Institute, Boise

84113

Primary Children's Hospital, Salt Lake City

90027

Children's Hospital Los Angeles, Los Angeles

90242

Kaiser Permanente Downey Medical Center, Downey

92123

Rady Children's Hospital - San Diego, San Diego

92354

Loma Linda University Medical Center, Loma Linda

92868

Children's Hospital of Orange County, Orange

94158

UCSF Medical Center-Mission Bay, San Francisco

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96826

Kapiolani Medical Center for Women and Children, Honolulu

97239

Oregon Health and Science University, Portland

98105

Seattle Children's Hospital, Seattle

99204

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

72202-3591

Arkansas Children's Hospital, Little Rock

94609-1809

Children's Hospital and Research Center at Oakland, Oakland

06520

Yale University, New Haven

04401

Eastern Maine Medical Center, Bangor

04074

Maine Children's Cancer Program, Scarborough

02215

Dana-Farber Cancer Institute, Boston

03756

Dartmouth Hitchcock Medical Center, Lebanon

05405

University of Vermont and State Agricultural College, Burlington

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT02452554 - Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma | Biotech Hunter | Biotech Hunter