IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA

PHASE4CompletedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

August 31, 2015

Primary Completion Date

September 30, 2017

Study Completion Date

December 31, 2017

Conditions
Rheumatoid Arthritis
Interventions
OTHER

Lab Work

Lab work to measure IL-7 and IL-7R

DRUG

Certolizumab pegol (CDP870, tradename Cimzia)(prefilled syringes at the dose of 200mg)

"Certolizumab pegol (CDP870, tradename Cimzia) or is provided in prefilled syringes at the dose of 200mg.~Patients received 2x200mg at weeks 0, 2 and 4. Additionally a maintenance dose of 200mg is given every 2 weeks. Treatment is performed through subcutaneous injection."

DRUG

Certolizumab pegol (CDP870, tradename Cimzia)

"rtolizumab pegol (CDP870, tradename Cimzia) or is provided in prefilled syringes at the dose of 200mg.~Patients received 2x200mg at weeks 0, 2 and 4. Additionally a maintenance dose of 200mg is given every 2 weeks. Treatment is performed through subcutaneous injection."

DRUG

Hydroxychloroquine

some patients are on 400mg/day of hydroxychloroquine.

DRUG

Sulfasalazine

some patients are on 300 mg/day and some patients are on 1000 mg/day dose of sulfasalazine

DRUG

Medrol

some patients are on 8mg/day of medrol

DRUG

Prednisone

some patients are on 10mg /day, some patients are on 20 mg/day, some patients are on 2.5 mg/day, some patients are on 30 mg/day, and some patients are on 5 mg/day of prednisone

DRUG

Triamcinolone

some patients are on Triamcinolone 40-80mg IM monthly (received 40mg dose 1 week before blood draw, off enbrel 50mg weekly and SSZ 1000mg bid for \~ 3 months) some patients are on Triamcinolone 40mg IM monthly

DRUG

Naproxen

some patients are on 1000 mg/day of naproxen

DRUG

Leflunomide

some patients are on 20mg/day of leflunomide

DRUG

Methotrexate

some patients are on 20mg weekly, some patients are on 25mg weekly, some patients are on 17.5 mg, some patients are on 15 mg weekly, some patients are on 7.5 mg weekly, and some patients are on 15 mg weekly dose of methotrexate

DRUG

humira

some patients are on Humira 40mg q2weeks

Trial Locations (1)

60612

Outpatient Care Center, Chicago

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

UCB Pharma

INDUSTRY

lead

University of Illinois at Chicago

OTHER