Deep vs Moderate Neuromuscular Blockade With Rocuronium in Patients Undergoing Endolaryngeal Procedures

PHASE4CompletedINTERVENTIONAL
Enrollment

102

Participants

Timeline

Start Date

June 30, 2016

Primary Completion Date

March 31, 2018

Study Completion Date

March 31, 2018

Conditions
Laryngoscopic Surgical Procedures
Interventions
PROCEDURE

Deep Neuromuscular Blockade

"* During maintenance phase, if recovery after 1 Post-Tetanic-count (PTC) responses, a continuous infusion can be initiated to maintain deep NMB (TOF =0, PTC 1-2).~* At the end of surgery, continuous infusion Rocuronium and Propofol are discontinued and paralysis will be simultaneously reversed by Sugammadex 4mg/kg from PTC 1-2."

PROCEDURE

Moderate Neuromuscular Blockade

\- During maintenance phase, if recovery at the presence of \<10% of control T1 of TOF from initial doses of 0.6 mg rocuronium, a continuous infusion can be initiated to maintain TOF = 1 - 2. The initial pump rate will be set at 0.5 mg/kg per hour.

DRUG

Sugammadex

DRUG

Rocuronium

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Chulalongkorn University

OTHER

NCT02451202 - Deep vs Moderate Neuromuscular Blockade With Rocuronium in Patients Undergoing Endolaryngeal Procedures | Biotech Hunter | Biotech Hunter