55
Participants
Start Date
September 30, 2015
Primary Completion Date
January 25, 2018
Study Completion Date
January 25, 2018
Tadalafil
single dose, 20 mg capsule p.o.
Placebo
single dose, matching capsule p.o.
Cognitive functioning tests
Cognitive function tests will be performed prior to MRI scan 1 performed prior to IMP dosing on 2 occasions as patient will act as their own control
Neuropsychological tests
"Neuropsychological tests will be performed prior to pre IMP dose MRI scan \& then parallel V2 of the tests repeated 3-5 post IMP dose and before 2nd MRI scan.~Participants act as own controls as 1 IMP occasion will be placebo- 2nd IMP occasion will be active. 7-30 days apart"
MRI Scan - Arterial Spin Labelling
Pre and post IMP dose on 2 occasions to detect difference in blood flow in deep brain 4 MRI scans in total
St George's Healthcare NHS Trust, London
Alzheimer's Drug Discovery Foundation
OTHER
Alzheimer's Society
OTHER
University of Copenhagen
OTHER
University of Glasgow
OTHER
St George's University Hospitals NHS Foundation Trust
OTHER
St George's, University of London
OTHER