120
Participants
Start Date
October 31, 2015
Primary Completion Date
October 31, 2019
Study Completion Date
October 31, 2025
Consolidation involved-site radiotherapy (ISRT)
"six cycles modern CHOP chemotherapy. Involved-site radiotherapy (ISRT) is based on defining the site of gross disease before chemotherapy, the GTV and using a CT-based volume with an expansion to form a CTV in the cranio-caudal direction.~Involved-site radiotherapy (ISRT) is given in 24Gy\~30Gy in 12\~15 fractions of 2 Gy 5 days per week."
Consolidation involved-field radiotherapy (IFRT)
"six cycles modern CHOP chemotherapy. Radiotherapy field of involved-field radiotherapy defined by CALGB is encompassed the prechemotherapy gross tumor.~Involved-field RT (IFRT) is given in 24Gy\~30Gy in 12\~15 fractions of 2 Gy 5 days per week."
cyclophosphamide
patients in both arms will be given cyclophosphamide chemotherapy.
doxorubicin
patients in both arms will be given cyclophosphamide chemotherapy.
vincristine
patients in both arms will be given cyclophosphamide chemotherapy.
prednisone
patients in both arms will be given cyclophosphamide chemotherapy.
RECRUITING
DiDeng, Wuhan
Wuhan University
OTHER