Study of Tumour Focused Radiotherapy for Bladder Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

345

Participants

Timeline

Start Date

October 21, 2015

Primary Completion Date

December 31, 2021

Study Completion Date

March 31, 2029

Conditions
Bladder Cancer
Interventions
RADIATION

WBRT

One RT plan with whole bladder treated to standard dose.

RADIATION

SART

Three plans (small, medium \& large) generated with the standard dose of RT focused on the tumour, sparing the normal bladder from full dose radiation. Pretreatment cone beam CTs will be used to select the best fitting of the three plans prior to treatment.

RADIATION

DART

Three plans (small, medium \& large) generated with a higher dose than standard focused on the tumour and the remainder of the bladder treated to the same dose as in the SART group. Pretreatment cone beam CTs will be used to select the best fitting of the three plans prior to treatment.

Trial Locations (49)

Unknown

Riverina Cancer Care Centre, Wagga Wagga

Princess Alexandra Hospital, Brisbane

Townsville General Hospital, Douglas

Radiation Oncology Mater Centre QLD, South Brisbane

Royal Hobart Hospital, Hobart

Austin Hospital, Melbourne

Sir Charles Gairdner Hospital, Nedlands

Auckland Hospital, Auckland

Christchurch Hospital, Christchurch

Waikato, Hamilton

Torbay District General Hospital, Torquay

Queen's Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Romford

Mount Vernon Cancer Centre, Northwood

Maidstone Hospital, Kent Oncology Centre, Adstone

Belfast City Hospital, Belfast

Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham

Queen Elizabeth Hospital, University Hospitals Birmingham NHS Trust, Birmingham

Bradford Teaching Hospitals NHS Foundation Trust, Bradford

Royal Sussex County Hospital, Brighton

Bristol Haematology & Oncology Centre, Brixton

West Suffolk Hospital, Bury St Edmunds

Addenbrooke's Hospital, Cambridge

Velindre Hospital, Cardiff and Vale NHS Trust, Cardiff

Cheltenham General Hospital, Cheltenham

University Hospital Coventry, Coventry

Western General Hospital, Edinburgh

Royal Devon and Exeter Hospital, Exeter

Beatson West of Scotland Cancer Centre, Glasgow

St Luke's Cancer Centre, Guildford

Leeds Teaching Hospitals NHS Trust, Leeds

Guy's and St Thomas' Hospital, London

Royal Marsden NHSFT, London

Royal Oldham Hospital, Manchester

The Clatterbridge Cancer Centre NHS Foundation Trust, Metropolitan Borough of Wirral

Northern Centre for Cancer Care, Freeman Hospital,, Newcastle upon Tyne

Norfolk and Norwich University Hospital, Norwich

The Royal Oldham Hospital, Oldham

Peterborough City Hospital, Peterborough

Queen Alexandra Hospital, Portsmouth

Royal Preston Hospital, Preston

Weston Park Hospital, Sheffield Teaching Hospitals Trust, Sheffield

Kings Mill Hospital, Sherwood Forest Hospitals Foundation NHS Trust, Sutton in Ashfield

Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton

Mid Yorkshire Hospitals, Wakefield

Pinderfields hospital, The Mid Yorkshire Hospitals NHS Trust, Wakefield

EC1M 6BQ

Barts Health NHS Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

NG5 1PB

Nottingham University Hospital NHS Trust, Nottingham

KA6 6DX

Ayr Hospital, Ayr

All Listed Sponsors
collaborator

Trans Tasman Radiation Oncology Group

OTHER

lead

Institute of Cancer Research, United Kingdom

OTHER