NCT02446964 - Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 25, 2015

Primary Completion Date

May 20, 2025

Study Completion Date

May 20, 2025

Conditions

Adult Acute Lymphoblastic Leukemia in Complete RemissionAcute Myeloid Leukemia in RemissionPreviously Treated Myelodysplastic SyndromeRecurrent Adult Acute Lymphoblastic LeukemiaRecurrent Adult Acute Myeloid LeukemiaRecurrent Childhood Acute Lymphoblastic LeukemiaRecurrent Childhood Acute Myeloid LeukemiaChildhood Acute Lymphoblastic Leukemia in Complete Remission

Interventions

PROCEDURE

Bone Marrow Transplantation

Undergo bone marrow transplant

DRUG

Cyclophosphamide

Given IV

DRUG

Fludarabine Phosphate

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Mycophenolate Mofetil

Given PO or IV

PROCEDURE

Peripheral Blood Stem Cell Transplantation

Undergo peripheral blood stem cell transplant

DRUG

Tacrolimus

Given IV and PO

RADIATION

Total Marrow Irradiation

Undergo TMLI

Trial Locations (1)

91010

City of Hope Comprehensive Cancer Center, Duarte

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER