579
Participants
Start Date
March 28, 2016
Primary Completion Date
February 23, 2020
Study Completion Date
August 23, 2026
Biospecimen Collection
Undergo blood sample collection
Carboplatin
Given IV
Cediranib Maleate
Given PO
Computed Tomography
Undergo CT
Echocardiography Test
Undergo ECHO
Gemcitabine
Given IV
Gemcitabine Hydrochloride
Given IV
Laboratory Biomarker Analysis
Correlative studies
Magnetic Resonance Imaging
Undergo MRI
Multigated Acquisition Scan
Undergo MUGA
Olaparib
Given PO
Paclitaxel
Given IV
Pegylated Liposomal Doxorubicin Hydrochloride
Given IV
Pharmacological Study
Correlative studies
Quality-of-Life Assessment
Ancillary studies
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center-Einstein Campus, The Bronx
Dickstein Cancer Treatment Center, White Plains
Memorial Sloan Kettering Westchester, Harrison
State University of New York Downstate Medical Center, Brooklyn
Memorial Sloan Kettering Nassau, Uniondale
Memorial Sloan Kettering Commack, Commack
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
West Penn Hospital, Pittsburgh
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
Adams Cancer Center, Gettysburg
WellSpan Health-York Hospital, York
Ephrata Cancer Center, Ephrata
Lancaster General Hospital, Lancaster
UPMC Susquehanna, Williamsport
Geisinger Medical Center, Danville
Geisinger Medical Oncology-Selinsgrove, Selinsgrove
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem
Guthrie Medical Group PC-Robert Packer Hospital, Sayre
Jefferson Abington Hospital, Abington
University of Pennsylvania/Abramson Cancer Center, Philadelphia
Thomas Jefferson University Hospital, Philadelphia
Reading Hospital, West Reading
Helen F Graham Cancer Center, Newark
Christiana Care Health System-Christiana Hospital, Newark
Beebe Health Campus, Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center, Seaford
Sibley Memorial Hospital, Washington D.C.
Greater Baltimore Medical Center, Baltimore
MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
University of Maryland Shore Medical Center at Easton, Easton
University of Virginia Cancer Center, Charlottesville
VCU Massey Comprehensive Cancer Center, Richmond
West Virginia University Charleston Division, Charleston
Edwards Comprehensive Cancer Center, Huntington
Wake Forest University Health Sciences, Winston-Salem
Southeastern Medical Oncology Center-Goldsboro, Goldsboro
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke Cancer Center Raleigh, Raleigh
Duke University Medical Center, Durham
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst
Novant Health New Hanover Regional Medical Center, Wilmington
Southeastern Medical Oncology Center-Jacksonville, Jacksonville
Spartanburg Medical Center, Spartanburg
Gibbs Cancer Center-Gaffney, Gaffney
SMC Center for Hematology Oncology Union, Union
Medical University of South Carolina, Charleston
Saint Francis Hospital, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Saint Francis Cancer Center, Greenville
AnMed Health Cancer Center, Anderson
Gibbs Cancer Center-Pelham, Greer
Emory Decatur Hospital, Decatur
Piedmont Hospital, Atlanta
Northside Hospital, Atlanta
University Cancer and Blood Center LLC, Athens
Atrium Health Navicent, Macon
Memorial Health University Medical Center, Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
University of Florida Health Science Center - Gainesville, Gainesville
University of Alabama at Birmingham Cancer Center, Birmingham
University of South Alabama Mitchell Cancer Institute, Mobile
Vanderbilt University/Ingram Cancer Center, Nashville
Wellmont Medical Associates Oncology and Hematology-Johnson City, Johnson City
Ballad Health Cancer Care - Kingsport, Kingsport
Wellmont Holston Valley Hospital and Medical Center, Kingsport
Thompson Cancer Survival Center, Knoxville
Thompson Cancer Survival Center - West, Knoxville
Saint Dominic-Jackson Memorial Hospital, Jackson
University of Mississippi Medical Center, Jackson
Norton Hospital Pavilion and Medical Campus, Louisville
Norton Suburban Hospital and Medical Campus, Louisville
Norton Brownsboro Hospital and Medical Campus, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Ohio State University Comprehensive Cancer Center, Columbus
Columbus Oncology and Hematology Associates Inc, Columbus
Riverside Methodist Hospital, Columbus
The Mark H Zangmeister Center, Columbus
ProMedica Flower Hospital, Sylvania
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
Case Western Reserve University, Cleveland
MetroHealth Medical Center, Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
UHHS-Chagrin Highlands Medical Center, Beachwood
Hillcrest Hospital Cancer Center, Mayfield Heights
UHHS-Westlake Medical Center, Westlake
Cleveland Clinic Foundation, Cleveland
University Hospitals Sharon Health Center, Wadsworth
Summa Health System - Akron Campus, Akron
Cleveland Clinic Akron General, Akron
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
Good Samaritan Hospital - Cincinnati, Cincinnati
TriHealth Cancer Institute-Westside, Cincinnati
Grandview Hospital, Dayton
Wright-Patterson Medical Center, Wright-Patterson Air Force Base
Orion Cancer Care, Findlay
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
Henry Ford Health Providence Southfield Hospital, Southfield
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Henry Ford Cancer Institute-Downriver, Brownstown
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
Henry Ford West Bloomfield Hospital, West Bloomfield
Weisberg Cancer Treatment Center, Farmington Hills
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
University of Michigan Health - Sparrow Lansing, Lansing
West Michigan Cancer Center, Kalamazoo
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Munson Medical Center, Traverse City
OSF Saint Francis Hospital and Medical Group, Escanaba
Green Bay Oncology-Manistique, Manistique
Mercy Medical Center-West Lakes, West Des Moines
Iowa Methodist Medical Center, Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
ProHealth D N Greenwald Center, Mukwonago
ProHealth Waukesha Memorial Hospital, Waukesha
UW Cancer Center at ProHealth Care, Waukesha
Medical College of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Saint Vincent Hospital Cancer Center at Marinette, Marinette
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
Marshfield Clinic-Wausau Center, Wausau
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Aspirus Cancer Care - Stevens Point, Stevens Point
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids
Marshfield Medical Center - Minocqua, Minocqua
Gundersen Lutheran Medical Center, La Crosse
Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire
Marshfield Clinic-Chippewa Center, Chippewa Falls
Marshfield Medical Center - Ladysmith, Ladysmith
Marshfield Medical Center-Rice Lake, Rice Lake
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Saint John's Hospital - Healtheast, Maplewood
Minnesota Oncology Hematology PA-Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
Saint Francis Regional Medical Center, Shakopee
Abbott-Northwestern Hospital, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
University of Minnesota/Masonic Cancer Center, Minneapolis
Mayo Clinic in Rochester, Rochester
Mayo Clinic Health Systems-Mankato, Mankato
Sanford Joe Lueken Cancer Center, Bemidji
Sanford Cancer Center Oncology Clinic, Sioux Falls
Avera Cancer Institute, Sioux Falls
Rapid City Regional Hospital, Rapid City
Sanford Broadway Medical Center, Fargo
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Trinity Cancer Care Center, Minot
Billings Clinic Cancer Center, Billings
Benefis Sletten Cancer Institute, Great Falls
Community Medical Center, Missoula
Logan Health Medical Center, Kalispell
NorthShore University HealthSystem-Glenbrook Hospital, Glenview
NorthShore University HealthSystem-Highland Park Hospital, Highland Park
Advocate Lutheran General Hospital, Park Ridge
Northwestern Medicine Cancer Center Delnor, Geneva
NorthShore University HealthSystem-Evanston Hospital, Evanston
Rush-Copley Medical Center, Aurora
Sudarshan K Sharma MD Limited-Gynecologic Oncology, Hinsdale
Northwestern Medicine Cancer Center Warrenville, Warrenville
Northwestern University, Chicago
John H Stroger Jr Hospital of Cook County, Chicago
Rush University Medical Center, Chicago
UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital, Chicago
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Peru, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare-Peoria, Peoria
Illinois CancerCare-Bloomington, Bloomington
Cancer Care Center of O'Fallon, O'Fallon
Illinois CancerCare-Carthage, Carthage
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Centralia Oncology Clinic, Centralia
Barnes-Jewish Hospital, St Louis
Washington University School of Medicine, St Louis
Saint Francis Medical Center, Cape Girardeau
Mercy Hospital Joplin, Joplin
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
University of Kansas Cancer Center, Kansas City
Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka
Mercy Hospital Pittsburg, Pittsburg
Associates In Womens Health, Wichita
Ascension Via Christi Hospitals Wichita, Wichita
Nebraska Methodist Hospital, Omaha
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island
CHI Health Good Samaritan, Kearney
Ochsner Medical Center Jefferson, New Orleans
Women's Cancer Care-Covington, Covington
Mary Bird Perkins Cancer Center, Baton Rouge
Woman's Hospital, Baton Rouge
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
Parkland Memorial Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Texas Oncology Bedford, Bedford
Texas Oncology - Fort Worth Cancer Center, Fort Worth
Houston Methodist Hospital, Houston
Methodist Willowbrook Hospital, Houston
Texas Oncology-The Woodlands, The Woodlands
Houston Methodist Sugar Land Hospital, Sugar Land
Texas Oncology - Central Austin Cancer Center, Austin
Texas Oncology - South Austin Cancer Center, Austin
Rocky Mountain Cancer Centers-Aurora, Aurora
Kaiser Permanente-Rock Creek, Lafayette
UCHealth University of Colorado Hospital, Aurora
Rocky Mountain Cancer Centers-Littleton, Littleton
Kaiser Permanente-Lone Tree, Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree
Kaiser Permanente-Franklin, Denver
Rocky Mountain Cancer Centers-Rose, Denver
Intermountain Health Lutheran Hospital, Wheat Ridge
Poudre Valley Hospital, Fort Collins
Penrose-Saint Francis Healthcare, Colorado Springs
UCHealth Memorial Hospital Central, Colorado Springs
Saint Luke's Cancer Institute - Fruitland, Fruitland
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Cancer Institute - Boise, Boise
Utah Cancer Specialists-Salt Lake City, Salt Lake City
Intermountain Medical Center, Murray
Saint George Regional Medical Center, St. George
Arizona Oncology Associates-West Orange Grove, Tucson
Arizona Oncology Associates-Wilmot, Tucson
Southwest Gynecologic Oncology Associates Inc, Albuquerque
University of New Mexico Cancer Center, Albuquerque
Memorial Medical Center-Las Cruces, Las Cruces
Women's Cancer Center of Nevada, Las Vegas
Cedars Sinai Medical Center, Los Angeles
UC San Diego Moores Cancer Center, La Jolla
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo
PCR Oncology, Arroyo Grande
Palo Alto Medical Foundation-Camino Division, Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
California Pacific Medical Center-Pacific Campus, San Francisco
Kaiser Permanente-San Francisco, San Francisco
UCSF Medical Center-Mission Bay, San Francisco
Palo Alto Medical Foundation Health Care, Palo Alto
Kaiser Permanente-Vallejo, Vallejo
Kaiser Permanente-Walnut Creek, Walnut Creek
Kaiser Permanente-Oakland, Oakland
Marin Cancer Care Inc, Greenbrae
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz
Sutter Pacific Medical Foundation, Santa Rosa
Mercy San Juan Medical Center, Carmichael
Sutter Roseville Medical Center, Roseville
Woodland Memorial Hospital, Woodland
Mercy Cancer Center - Sacramento, Sacramento
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Kaiser Permanente Sacramento Medical Center, Sacramento
Queen's Medical Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Legacy Mount Hood Medical Center, Gresham
Legacy Meridian Park Hospital, Tualatin
Legacy Good Samaritan Hospital and Medical Center, Portland
Kaiser Permanente Northwest, Portland
Willamette Valley Cancer Center, Eugene
Saint Charles Health System, Bend
Pacific Gynecology Specialists, Seattle
Fred Hutchinson Cancer Center, Seattle
Swedish Medical Center-First Hill, Seattle
University of Washington Medical Center - Northwest, Seattle
Women's Cancer Center of Seattle, Seattle
University of Washington Medical Center - Montlake, Seattle
Skagit Regional Health Cancer Care Center, Mount Vernon
Skagit Valley Hospital, Mount Vernon
Legacy Salmon Creek Hospital, Vancouver
Wenatchee Valley Hospital and Clinics, Wenatchee
Kadlec Clinic Hematology and Oncology, Kennewick
Alaska Women's Cancer Care, Anchorage
Providence Alaska Medical Center, Anchorage
Smilow Cancer Hospital Care Center-Fairfield, Fairfield
Hartford Hospital, Hartford
Smilow Cancer Hospital Care Center at Saint Francis, Hartford
Middlesex Hospital, Middletown
The Hospital of Central Connecticut, New Britain
Yale University, New Haven
Smilow Cancer Hospital-Torrington Care Center, Torrington
Smilow Cancer Hospital Care Center-Trumbull, Trumbull
Eastern Maine Medical Center, Bangor
Lafayette Family Cancer Center-EMMC, Brewer
MaineHealth Maine Medical Center- Scarborough, Scarborough
Tufts Medical Center, Boston
Brigham and Women's Hospital, Boston
Dana-Farber Cancer Institute, Boston
Lahey Hospital and Medical Center, Burlington
Wentworth-Douglass Hospital, Dover
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Dartmouth Cancer Center - Nashua, Nashua
Memorial Sloan Kettering Basking Ridge, Basking Ridge
Cooper Hospital University Medical Center, Camden
Englewood Hospital and Medical Center, Englewood
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township
Women and Infants Hospital, Providence
South Carolina Cancer Specialists PC, Hilton Head Island
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay
Arthur J E Child Comprehensive Cancer Centre, Calgary
Cross Cancer Institute, Edmonton
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton
London Regional Cancer Program, London
Ottawa Hospital and Cancer Center-General Campus, Ottawa
Algoma District Cancer Program Sault Area Hospital, Sault Ste. Marie
Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto
University Health Network-Princess Margaret Hospital, Toronto
CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal
Jewish General Hospital, Montreal
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke
Iwate Medical University Hospital, Shiwa-gun
Kagoshima City Hospital, Kagoshima
The Cancer Institute Hospital Of JFCR, Koto-ku
Saitama Medical University International Medical Center, Saitama
National Cancer Center Hospital, Tokyo
Seoul National University Hospital, Seoul
Collaborators (2)
AstraZeneca
INDUSTRY
NRG Oncology
OTHER
National Cancer Institute (NCI)
NIH