Testing the Use of A Single Drug (Olaparib) or the Combination of Two Drugs (Cediranib and Olaparib) Compared to the Usual Chemotherapy for Women With Platinum Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

579

Participants

Timeline

Start Date

March 28, 2016

Primary Completion Date

February 23, 2020

Study Completion Date

August 23, 2026

Conditions
Fallopian Tube Clear Cell AdenocarcinomaFallopian Tube Transitional Cell CarcinomaFallopian Tube Undifferentiated CarcinomaOvarian Clear Cell AdenocarcinomaOvarian Endometrioid TumorOvarian Seromucinous CarcinomaOvarian Serous TumorOvarian Transitional Cell CarcinomaOvarian Undifferentiated CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Ovarian CarcinomaRecurrent Ovarian Endometrioid AdenocarcinomaRecurrent Primary Peritoneal Carcinoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Carboplatin

Given IV

DRUG

Cediranib Maleate

Given PO

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Echocardiography Test

Undergo ECHO

DRUG

Gemcitabine

Given IV

DRUG

Gemcitabine Hydrochloride

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Olaparib

Given PO

DRUG

Paclitaxel

Given IV

DRUG

Pegylated Liposomal Doxorubicin Hydrochloride

Given IV

OTHER

Pharmacological Study

Correlative studies

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (356)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

10601

Dickstein Cancer Treatment Center, White Plains

10604

Memorial Sloan Kettering Westchester, Harrison

11203

State University of New York Downstate Medical Center, Brooklyn

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15224

West Penn Hospital, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17325

Adams Cancer Center, Gettysburg

17403

WellSpan Health-York Hospital, York

17522

Ephrata Cancer Center, Ephrata

17602

Lancaster General Hospital, Lancaster

17701

UPMC Susquehanna, Williamsport

17822

Geisinger Medical Center, Danville

17870

Geisinger Medical Oncology-Selinsgrove, Selinsgrove

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

18840

Guthrie Medical Group PC-Robert Packer Hospital, Sayre

19001

Jefferson Abington Hospital, Abington

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

19611

Reading Hospital, West Reading

19713

Helen F Graham Cancer Center, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19971

Beebe Health Campus, Rehoboth Beach

19973

TidalHealth Nanticoke / Allen Cancer Center, Seaford

20016

Sibley Memorial Hospital, Washington D.C.

21204

Greater Baltimore Medical Center, Baltimore

21237

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

21601

University of Maryland Shore Medical Center at Easton, Easton

22908

University of Virginia Cancer Center, Charlottesville

23298

VCU Massey Comprehensive Cancer Center, Richmond

25304

West Virginia University Charleston Division, Charleston

25701

Edwards Comprehensive Cancer Center, Huntington

27157

Wake Forest University Health Sciences, Winston-Salem

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27609

Duke Cancer Center Raleigh, Raleigh

27710

Duke University Medical Center, Durham

28374

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28401

Novant Health New Hanover Regional Medical Center, Wilmington

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29303

Spartanburg Medical Center, Spartanburg

29341

Gibbs Cancer Center-Gaffney, Gaffney

29379

SMC Center for Hematology Oncology Union, Union

29425

Medical University of South Carolina, Charleston

29601

Saint Francis Hospital, Greenville

29605

Prisma Health Cancer Institute - Faris, Greenville

29607

Saint Francis Cancer Center, Greenville

29621

AnMed Health Cancer Center, Anderson

29651

Gibbs Cancer Center-Pelham, Greer

30033

Emory Decatur Hospital, Decatur

30309

Piedmont Hospital, Atlanta

30342

Northside Hospital, Atlanta

30607

University Cancer and Blood Center LLC, Athens

31201

Atrium Health Navicent, Macon

31404

Memorial Health University Medical Center, Savannah

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

32610

University of Florida Health Science Center - Gainesville, Gainesville

35233

University of Alabama at Birmingham Cancer Center, Birmingham

36688

University of South Alabama Mitchell Cancer Institute, Mobile

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37604

Wellmont Medical Associates Oncology and Hematology-Johnson City, Johnson City

37660

Ballad Health Cancer Care - Kingsport, Kingsport

Wellmont Holston Valley Hospital and Medical Center, Kingsport

37916

Thompson Cancer Survival Center, Knoxville

37932

Thompson Cancer Survival Center - West, Knoxville

39216

Saint Dominic-Jackson Memorial Hospital, Jackson

University of Mississippi Medical Center, Jackson

40202

Norton Hospital Pavilion and Medical Campus, Louisville

40207

Norton Suburban Hospital and Medical Campus, Louisville

40241

Norton Brownsboro Hospital and Medical Campus, Louisville

40536

University of Kentucky/Markey Cancer Center, Lexington

43210

Ohio State University Comprehensive Cancer Center, Columbus

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43219

The Mark H Zangmeister Center, Columbus

43560

ProMedica Flower Hospital, Sylvania

43606

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44145

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44281

University Hospitals Sharon Health Center, Wadsworth

44304

Summa Health System - Akron Campus, Akron

44307

Cleveland Clinic Akron General, Akron

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45405

Grandview Hospital, Dayton

45433

Wright-Patterson Medical Center, Wright-Patterson Air Force Base

45840

Orion Cancer Care, Findlay

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48075

Henry Ford Health Providence Southfield Hospital, Southfield

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

Weisberg Cancer Treatment Center, Farmington Hills

48341

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

West Michigan Cancer Center, Kalamazoo

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

49684

Munson Medical Center, Traverse City

49829

OSF Saint Francis Hospital and Medical Group, Escanaba

49854

Green Bay Oncology-Manistique, Manistique

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

ProHealth D N Greenwald Center, Mukwonago

53188

ProHealth Waukesha Memorial Hospital, Waukesha

UW Cancer Center at ProHealth Care, Waukesha

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

Saint Vincent Hospital Cancer Center at Marinette, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54481

Aspirus Cancer Care - Stevens Point, Stevens Point

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54548

Marshfield Medical Center - Minocqua, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54848

Marshfield Medical Center - Ladysmith, Ladysmith

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55379

Saint Francis Regional Medical Center, Shakopee

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

56001

Mayo Clinic Health Systems-Mankato, Mankato

56601

Sanford Joe Lueken Cancer Center, Bemidji

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

57105

Avera Cancer Institute, Sioux Falls

57701

Rapid City Regional Hospital, Rapid City

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

58701

Trinity Cancer Care Center, Minot

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60068

Advocate Lutheran General Hospital, Park Ridge

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60504

Rush-Copley Medical Center, Aurora

60521

Sudarshan K Sharma MD Limited-Gynecologic Oncology, Hinsdale

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

Rush University Medical Center, Chicago

60657

UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

64804

Mercy Hospital Joplin, Joplin

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66160

University of Kansas Cancer Center, Kansas City

66606

Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka

66762

Mercy Hospital Pittsburg, Pittsburg

67208

Associates In Womens Health, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

68114

Nebraska Methodist Hospital, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68803

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island

68847

CHI Health Good Samaritan, Kearney

70121

Ochsner Medical Center Jefferson, New Orleans

70433

Women's Cancer Care-Covington, Covington

70809

Mary Bird Perkins Cancer Center, Baton Rouge

70817

Woman's Hospital, Baton Rouge

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76022

Texas Oncology Bedford, Bedford

76104

Texas Oncology - Fort Worth Cancer Center, Fort Worth

77030

Houston Methodist Hospital, Houston

77070

Methodist Willowbrook Hospital, Houston

77380

Texas Oncology-The Woodlands, The Woodlands

77479

Houston Methodist Sugar Land Hospital, Sugar Land

78731

Texas Oncology - Central Austin Cancer Center, Austin

78745

Texas Oncology - South Austin Cancer Center, Austin

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

80026

Kaiser Permanente-Rock Creek, Lafayette

80045

UCHealth University of Colorado Hospital, Aurora

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80124

Kaiser Permanente-Lone Tree, Lone Tree

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

80205

Kaiser Permanente-Franklin, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

80401

Intermountain Health Lutheran Hospital, Wheat Ridge

80524

Poudre Valley Hospital, Fort Collins

80907

Penrose-Saint Francis Healthcare, Colorado Springs

80909

UCHealth Memorial Hospital Central, Colorado Springs

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84770

Saint George Regional Medical Center, St. George

85704

Arizona Oncology Associates-West Orange Grove, Tucson

85710

Arizona Oncology Associates-Wilmot, Tucson

87106

Southwest Gynecologic Oncology Associates Inc, Albuquerque

University of New Mexico Cancer Center, Albuquerque

88011

Memorial Medical Center-Las Cruces, Las Cruces

89106

Women's Cancer Center of Nevada, Las Vegas

90048

Cedars Sinai Medical Center, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

PCR Oncology, Arroyo Grande

94040

Palo Alto Medical Foundation-Camino Division, Mountain View

Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

California Pacific Medical Center-Pacific Campus, San Francisco

Kaiser Permanente-San Francisco, San Francisco

94158

UCSF Medical Center-Mission Bay, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

94904

Marin Cancer Care Inc, Greenbrae

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95065

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95403

Sutter Pacific Medical Foundation, Santa Rosa

95608

Mercy San Juan Medical Center, Carmichael

95661

Sutter Roseville Medical Center, Roseville

95695

Woodland Memorial Hospital, Woodland

95816

Mercy Cancer Center - Sacramento, Sacramento

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95825

Kaiser Permanente Sacramento Medical Center, Sacramento

96813

Queen's Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97030

Legacy Mount Hood Medical Center, Gresham

97062

Legacy Meridian Park Hospital, Tualatin

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97227

Kaiser Permanente Northwest, Portland

97401

Willamette Valley Cancer Center, Eugene

97701

Saint Charles Health System, Bend

98104

Pacific Gynecology Specialists, Seattle

98109

Fred Hutchinson Cancer Center, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98133

University of Washington Medical Center - Northwest, Seattle

Women's Cancer Center of Seattle, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98274

Skagit Regional Health Cancer Care Center, Mount Vernon

Skagit Valley Hospital, Mount Vernon

98686

Legacy Salmon Creek Hospital, Vancouver

98801

Wenatchee Valley Hospital and Clinics, Wenatchee

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99508

Alaska Women's Cancer Care, Anchorage

Providence Alaska Medical Center, Anchorage

06824

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06102

Hartford Hospital, Hartford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06457

Middlesex Hospital, Middletown

06050

The Hospital of Central Connecticut, New Britain

06520

Yale University, New Haven

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

04401

Eastern Maine Medical Center, Bangor

04412

Lafayette Family Cancer Center-EMMC, Brewer

04074

MaineHealth Maine Medical Center- Scarborough, Scarborough

02111

Tufts Medical Center, Boston

02115

Brigham and Women's Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

01805

Lahey Hospital and Medical Center, Burlington

03820

Wentworth-Douglass Hospital, Dover

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

03063

Dartmouth Cancer Center - Nashua, Nashua

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

08103

Cooper Hospital University Medical Center, Camden

07631

Englewood Hospital and Medical Center, Englewood

08043

MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township

02905

Women and Infants Hospital, Providence

29926-3827

South Carolina Cancer Specialists PC, Hilton Head Island

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

T2N 5G2

Arthur J E Child Comprehensive Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

N6A 4L6

London Regional Cancer Program, London

K1H 8L6

Ottawa Hospital and Cancer Center-General Campus, Ottawa

P6B 0A8

Algoma District Cancer Program Sault Area Hospital, Sault Ste. Marie

M4N 3M5

Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

H1T 2M4

CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal

H2X 3E4

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

H3T 1E2

Jewish General Hospital, Montreal

G1R 2J6

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec

J1H 5N4

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

028-3695

Iwate Medical University Hospital, Shiwa-gun

890-8760

Kagoshima City Hospital, Kagoshima

135-8550

The Cancer Institute Hospital Of JFCR, Koto-ku

350-1298

Saitama Medical University International Medical Center, Saitama

104 0045

National Cancer Center Hospital, Tokyo

110-744

Seoul National University Hospital, Seoul

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH