Enzalutamide in Androgen Deprivation Therapy With Radiation Therapy for High Risk, Clinically Localised, Prostate Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

802

Participants

Timeline

Start Date

March 31, 2014

Primary Completion Date

June 30, 2025

Study Completion Date

March 31, 2026

Conditions
Prostatic Neoplasms
Interventions
DRUG

Enzalutamide

DRUG

Conventional NSAA

DRUG

LHRHA

RADIATION

External Beam Radiotherapy (78 Gy in 39 fractions or 46 Gy in 23 fractions plus brachytherapy boost)

Trial Locations (69)

1000

The Institute Of Oncology, Ljubljana

1142

Auckland City Hospital, Auckland

2010

St Vincent's Hospital, Sydney

2050

Chris O'Brien Lifehouse, Camperdown

2065

Royal North Shore Hospital, St Leonards

2076

Sydney Adventist Hospital, Wahroonga

2131

Prince of Wales Hospital, Randwick

2145

Westmead Hospital, Westmead

2148

Blacktown Hospital, Blacktown

2170

Liverpool Hospital, Liverpool

2217

St George Hospital, Kogarah

2250

Gosford Hospital, Gosford

2290

Genesis Cancer Care Newcastle, Gateshead

2298

Calvary Mater Newcastle, Waratah

2340

Tamworth Rural Referral Hospital, Tamworth

2500

Wollongong Hospital, Wollongong

2560

Campbelltown Hospital, Campbelltown

2800

Orange Health Service, Orange

3002

Peter MacCallum Cancer Centre, Melbourne

3011

Genesis Care - Western (formerly WROC), Footscray

3021

Sunshine Hospital, St Albans

3076

Genesis Care - Epping (formerly EROC), Epping

3084

Austin Health, Heidelberg

3121

Epworth HealthCare - Richmond, Richmond

3128

Eastern Health (Box Hill Hospital), Box Hill

3135

Genesis Care - Ringwood (formerly RROC), Ringwood East

3165

Peter MacCallum Cancer Centre (Moorabbin Campus), Bentleigh East

3199

Genesis Care - Frankston (formerly FROC), Frankston

3550

Peter MacCallum Cancer Centre, Bendigo

4006

Royal Brisbane & Womens Hospital, Herston

4066

Genesis Cancer Care Queensland - Wesley and Chermside, Auchenflower

4101

Radiation Oncology Services Mater Centre, South Brisbane

4102

Princess Alexandra Hospital Brisbane, Woolloongabba

4170

Christchurch Hospital, Christchurch

4215

ICON - Gold Coast (formerly ROC Gold Coast), Southport

4224

Genesis Cancer Care Queensland - Tugun and Southport, Tugun

4350

ICON - Toowoomba (formerly ROC Toowoomba), Toowoomba

4442

Palmerston North Hospital, Palmerston North

4560

Nambour General Hospital, Nambour

4814

Townsville Hospital, Douglas

5000

Royal Adelaide Hospital, Adelaide

5020

Salzburger Landeskliniken - Universitätsklinikum Salzburg, Salzburg

5037

Ashford Cancer Centre Research (Adelaide Cancer Centre), Kurralta Park

5042

Flinders Medical Centre, Bedford Park

6149

Fiona Stanley Hospital, Murdoch

7000

Royal Hobart Hospital, Hobart

8500

AZ Groeninge Kortrijk- Campus Kennedylaan, Kortrijk

20014

Hospital Donostia, Donostia / San Sebastian

37007

Hospital Universitario de Salamanca, Salamanca

02115

Dana Farber Cancer Institute, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Unknown

Cork University Hospital, Cork

Galway University Hospital, Galway

Addenbrookes Hospital, Cambridge

Dublin 7

Mater Misericordiae University Hospital, Dublin

Mater Private Hospital, Dublin

Dublin 18

Beacon Private Hospital, Dublin

Dublin 6

St Luke's Hospital, Dublin

08916

Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia), Badalona

CF14 2TL

Velindre Hospital, Whitchurch

SO16 6YD

University Hospital Southhampton, Southampton

CT1 3NG

Kent and Canterbury Hospital, Canterbury

SW3 6JJ

Royal Marsden Hospital, Chelsea

EH4 2XU

Western General Hospital, Edinburgh

BA1 3NG

Royal United Hospital Bath, Bath

NW1 2BU

University of London Hospital, London

SE1 9RT

Guys and St Thomas Hospital, London

W6 8RF

Charring Cross Hospital: Imperial College Healthcare NHS Trust, London

NG5 1PB

Nottingham City Hospital- City Campus, Nottingham

All Listed Sponsors
collaborator

Australian and New Zealand Urogenital and Prostate Cancer Trials Group

OTHER

collaborator

National Health and Medical Research Council, Australia

OTHER

collaborator

Cancer Trials Ireland

NETWORK

collaborator

Trans Tasman Radiation Oncology Group

OTHER

collaborator

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

lead

University of Sydney

OTHER