52
Participants
Start Date
August 17, 2015
Primary Completion Date
September 26, 2018
Study Completion Date
September 26, 2018
Docetaxel
Participants will receive docetaxel in line with locally approved Prescribing Information. After Cycle 6 (cycle length = 21 days), continuation of docetaxel treatment will be at the discretion of the investigator. Docetaxel will be administered after pertuzumab and trastuzumab.
Pertuzumab
Participants will receive pertuzumab at an initial dose of 840 milligrams (mg) as a 60-minute intravenous infusion on Cycle 1 Day 1 (cycle length = 21 days), followed by every 3 weeks at a dose of 420 mg as a 30 to 60-minute intravenous infusion until disease progression, unacceptable toxicity, withdrawal of consent or death, whichever occurs first.
Trastuzumab
Participants will receive trastuzumab at an initial dose of 8 milligrams per kilogram (mg/kg) as a 90-minute intravenous infusion on Cycle 1 Day 1 (cycle length = 21 days), followed by every 3 weeks at a dose of 6 mg/kg as a 30 to 90-minute intravenous infusion until disease progression, unacceptable toxicity, withdrawal of consent or death, whichever occurs first.
MAX Balaji Hospital, Delhi
Tata Memorial Hospital; Dept of Medical Oncology, Mumbai
Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute, Mumbai
Jehangir Clinical Development Centre Pvt. Ltd; Cancer Research Room, Pune
Indo-American Cancer Hospital & Research Center, Hyderabad
M S Ramaiah Memorial Hospital, Bangalore
Christian Medical College & Hospital; Medicine, Vellore
TATA Medical Centre; Medical Oncology, Kolkata
Rajiv Gandhi Cancer Institute & Research Center, New Delhi
Hoffmann-La Roche
INDUSTRY