346
Participants
Start Date
September 2, 2015
Primary Completion Date
June 21, 2024
Study Completion Date
June 21, 2024
Corticosteroid boluses Methylprednisolone
"Intensification of the corticotherapy in accordance with the validated protocol for the treatment of classic and subclinical acute rejections: 3 bolus Methylprednisolone 500 mg IV at D1, D2 and D3 then decreasing during 10-15 days at 1mg/kg/d and down to the maintenance dose.~An anti-pneumocystis and anti-CMV prophylaxis will be systemically introduced for 3 months.~The rest of maintenance immunosuppressive regimen (mycophenolate mofetil and anti-calcineurin) will remain unaltered"
No therapeutic modification
No therapeutic modification: continuation of the corticotherapy at the maintenance dose and maintaining unaltered the rest of immunosuppressive treatment (mycophenolate mofetil and anti-calcineurin).
Stop maintenance corticotherapy
Immediate withdrawal of maintenance corticotherapy. Maintaining unaltered the rest of immunosuppressive treatment (mycophenolate mofetil and anti-calcineurin).
Service de Néphrologie, Hémodialyse, Transplantations Rénales - Hôpital de la Cavale Blanche - CHU de Brest, Brest
Département de Néphrologie et Transplantation d'Organes - Hôpital Rangueil - CHU de Toulouse, Toulouse
Service de Néphrologie,Transplantation, Dialyse I - Hôpital Pellegrin - CHU Bordeaux, Bordeaux
Institut de Transplantation, Urologie et Néphrologie (ITUN) - CHU de Nantes, Nantes
Service de Néphrologie - Hôpital Claude Huriez - CHU de Lille, Lille
Service de Néphrologie et Transplantation - Nouvel Hôpital Civil - CHRU Strasbourg, Strasbourg
Service de Néphrologie, Transplantation et Immunologie Clinique - Hôpital Edouard Herriot - Hospices Civils de Lyon, Lyon
Service de Transplantation - Hôpital Universitaire Necker, Paris
Hospices Civils de Lyon
OTHER