NCT02443155 - A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function | Biotech Hunter

Enrollment

308

Participants

Timeline

Start Date

November 10, 2015

Primary Completion Date

August 31, 2018

Study Completion Date

February 27, 2019

Conditions

DiabetesDiabetes Mellitus, Type 1

Interventions

DRUG

NNC0114-0006

NNC0114-0006 12 mg/kg administered i.v (intravenously) every 6 weeks. Subjects will continue their pre-trial insulin treatment

DRUG

liraglutide

Liraglutide 1.8 mg administered s.c. (subcutaneously) daily. Subjects will continue their pre-trial insulin treatment

DRUG

placebo

Placebo administered s.c (subcutaneously) or i.v ( intravenously). Subjects will continue their pre-trial insulin treatment

Trial Locations (108)

1030

Novo Nordisk Investigational Site, Vienna

1090

Novo Nordisk Investigational Site, Brussels

1130

Novo Nordisk Investigational Site, Vienna

2650

Novo Nordisk Investigational Site, Edegem

2900

Novo Nordisk Investigational Site, Hellerup

3000

Novo Nordisk Investigational Site, Leuven

4011

Novo Nordisk Investigational Site, Stavanger

5020

Novo Nordisk Investigational Site, Salzburg

6020

Novo Nordisk Investigational Site, Innsbruck

6700

Novo Nordisk Investigational Site, Esbjerg

8036

Novo Nordisk Investigational Site, Graz

8200

Novo Nordisk Investigational Site, Aarhus N

10002

Novo Nordisk Investigational Site, Zhytomyr

11000

Novo Nordisk Investigational Site, Belgrade

17007

Novo Nordisk Investigational Site, Girona

20132

Novo Nordisk Investigational Site, Milan

21010

Novo Nordisk Investigational Site, Vinnytsia

24127

Novo Nordisk Investigational Site, Bergamo

27517

Novo Nordisk Investigational Site, Chapel Hill

29010

Novo Nordisk Investigational Site, Málaga

30318

Novo Nordisk Investigational Site, Atlanta

32804

Novo Nordisk Investigational Site, Orlando

33136

Novo Nordisk Investigational Site, Miami

33520

Novo Nordisk Investigational Site, Tampere

34000

Novo Nordisk Investigational Site, Kragujevac

37203

Novo Nordisk Investigational Site, Nashville

40503

Novo Nordisk Investigational Site, Lexington

41003

Novo Nordisk Investigational Site, Seville

41009

Novo Nordisk Investigational Site, Seville

46026

Novo Nordisk Investigational Site, Valencia

49202

Novo Nordisk Investigational Site, Petah Tikva

53100

Novo Nordisk Investigational Site, Siena

58100

Novo Nordisk Investigational Site, Holon

75149

Novo Nordisk Investigational Site, Mesquite

76100

Novo Nordisk Investigational Site, Rehovot

77079

Novo Nordisk Investigational Site, Houston

80045

Novo Nordisk Investigational Site, Aurora

88100

Novo Nordisk Investigational Site, Catanzaro

89128

Novo Nordisk Investigational Site, Las Vegas

90220

Novo Nordisk Investigational Site, Oulu

91120

Novo Nordisk Investigational Site, Jerusalem

91325

Novo Nordisk Investigational Site, Northridge

92037

Novo Nordisk Investigational Site, La Jolla

123423

Novo Nordisk Investigational Site, Moscow

125315

Novo Nordisk Investigational Site, Moscow

140091

Novo Nordisk Investigational Site, Dzerzhinskiy

163001

Novo Nordisk Investigational Site, Arkhangelsk

167981

Novo Nordisk Investigational Site, Syktyvkar

199226

Novo Nordisk Investigational Site, Saint Petersburg

410031

Novo Nordisk Investigational Site, Saratov

410053

Novo Nordisk Investigational Site, Saratov

420012

Novo Nordisk Investigational Site, Kazan'

424004

Novo Nordisk Investigational Site, Yoshkar-Ola

432063

Novo Nordisk Investigational Site, Ulyanovsk

440026

Novo Nordisk Investigational Site, Penza

454048

Novo Nordisk Investigational Site, Chelyabinsk

630091

Novo Nordisk Investigational Site, Novosibirsk

07666

Novo Nordisk Investigational Site, Teaneck

T6G 2E1

Novo Nordisk Investigational Site, Edmonton

V5Z 1M9

Novo Nordisk Investigational Site, Vancouver

R3E 3P4

Novo Nordisk Investigational Site, Winnipeg

B3H 2Y9

Novo Nordisk Investigational Site, Halifax

K7L 2V7

Novo Nordisk Investigational Site, Kingston

M4G 3E8

Novo Nordisk Investigational Site, Toronto

H7T 2P5

Novo Nordisk Investigational Site, Laval

H4A 3T2

Novo Nordisk Investigational Site, Montreal

G1L 3L5

Novo Nordisk Investigational Site, PQ

J1H 5N4

Novo Nordisk Investigational Site, Sherbrooke

00290

Novo Nordisk Investigational Site, Helsinki

DUBLIN 15

Novo Nordisk Investigational Site, Dublin

DUBLIN 4

Novo Nordisk Investigational Site, Dublin

H91 YR71

Novo Nordisk Investigational Site, Galway

0586

Novo Nordisk Investigational Site, Oslo

80-214

Novo Nordisk Investigational Site, Gdansk

80-546

Novo Nordisk Investigational Site, Gdansk

04-736

Novo Nordisk Investigational Site, Warsaw

41-800

Novo Nordisk Investigational Site, Zabrze

2805-267

Novo Nordisk Investigational Site, Almada

2720-276

Novo Nordisk Investigational Site, Amadora

4710-243

Novo Nordisk Investigational Site, Braga

4464-513

Novo Nordisk Investigational Site, Matosinhos Municipality

4200-319

Novo Nordisk Investigational Site, Porto

4901-858

Novo Nordisk Investigational Site, Viana do Castelo

08035

Novo Nordisk Investigational Site, Barcelona

07198

Novo Nordisk Investigational Site, Palma de Mallorca

08208

Novo Nordisk Investigational Site, Sabadell

413 45

Novo Nordisk Investigational Site, Gothenburg

651 85

Novo Nordisk Investigational Site, Karlstad

221 85

Novo Nordisk Investigational Site, Lund