Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

94

Participants

Timeline

Start Date

October 12, 2016

Primary Completion Date

June 10, 2024

Study Completion Date

December 24, 2025

Conditions
Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell TypeRefractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type
Interventions
PROCEDURE

Autologous Bone Marrow Transplantation

Undergo autologous hematopoietic progenitor cells or bone marrow transplant

PROCEDURE

Autologous Hematopoietic Stem Cell Transplantation

Undergo autologous hematopoietic progenitor cells or bone marrow transplant

DRUG

Carmustine

Given IV

DRUG

Cyclophosphamide

Given IV

DRUG

Cytarabine

Given IV

DRUG

Etoposide

Given IV

DRUG

Ibrutinib

Given PO

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Melphalan

Given IV

OTHER

Pharmacogenomic Study

Correlative studies

OTHER

Placebo Administration

Given PO

Trial Locations (282)

10065

NYP/Weill Cornell Medical Center, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Children's Hospital at Montefiore, The Bronx

Montefiore Medical Center - Moses Campus, The Bronx

11211

King Faisal Specialist Hospital and Research Centre, Riyadh

13126

Upstate Cancer Center at Oswego, Oswego

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

16801

Geisinger Medical Group, State College

17044

Lewistown Hospital, Lewistown

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17870

Geisinger Medical Oncology-Selinsgrove, Selinsgrove

17901

Geisinger Cancer Services-Pottsville, Pottsville

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18510

Community Medical Center, Scranton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19111

Fox Chase Cancer Center, Philadelphia

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

TidalHealth Nanticoke / Allen Cancer Center, Seaford

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

University of Virginia Cancer Center, Charlottesville

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

27157

Wake Forest University Health Sciences, Winston-Salem

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Medical Center, Durham

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29325

Prisma Health Cancer Institute - Laurens, Clinton

29425

Medical University of South Carolina, Charleston

29601

Saint Francis Hospital, Greenville

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29607

Saint Francis Cancer Center, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Northside Hospital, Atlanta

30912

Augusta University Medical Center, Augusta

32610

University of Florida Health Science Center - Gainesville, Gainesville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33612

Moffitt Cancer Center, Tampa

37067

Vanderbilt-Ingram Cancer Center Cool Springs, Franklin

37204

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

43210

Ohio State University Comprehensive Cancer Center, Columbus

44106

Case Western Reserve University, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49009

Ascension Borgess Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49048

Ascension Borgess Hospital, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

Aurora BayCare Medical Center, Green Bay

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Medical Center-Marshfield, Marshfield

Marshfield Medical Center, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire

Marshfield Medical Center-EC Cancer Center, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54848

Marshfield Medical Center - Ladysmith, Ladysmith

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54937

Aurora Health Center-Fond du Lac, Fond du Lac

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

57105

Avera Cancer Institute, Sioux Falls

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59102

Saint Vincent Frontier Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60153

Loyola University Medical Center, Maywood

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

63104

SSM Health Saint Louis University Hospital, St Louis

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

66044

Lawrence Memorial Hospital, Lawrence

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66502

Cancer Center of Kansas-Manhattan, Manhattan

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

68118

Nebraska Medicine-Village Pointe, Omaha

68123

Nebraska Medicine-Bellevue, Bellevue

68198

University of Nebraska Medical Center, Omaha

70112

Tulane University School of Medicine, New Orleans

70121

Ochsner Medical Center Jefferson, New Orleans

70806

Baton Rouge General Medical Center, Baton Rouge

70809

Hematology/Oncology Clinic PLLC, Baton Rouge

71103

LSU Health Sciences Center at Shreveport, Shreveport

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

The Medical Center of Aurora, Aurora

80026

Good Samaritan Hospital - Cancer Centers of Colorado, Lafayette

80045

UCHealth University of Colorado Hospital, Aurora

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Swedish Medical Center, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

80204

Denver Health Medical Center, Denver

80206

National Jewish Health-Main Campus, Denver

80209

The Women's Imaging Center, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

Saint Joseph Hospital - Cancer Centers of Colorado, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

80303

Boulder Community Foothills Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80401

National Jewish Health-Western Hematology Oncology, Golden

Intermountain Health Lutheran Hospital, Wheat Ridge

80524

Poudre Valley Hospital, Fort Collins

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

80909

UCHealth Memorial Hospital Central, Colorado Springs

81501

Saint Mary's Hospital and Regional Medical Center, Grand Junction

81505

Grand Valley Oncology, Grand Junction

82001

Cheyenne Regional Medical Center-West, Cheyenne

82414

Billings Clinic-Cody, Cody

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

84003

American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork

84009

South Jordan Health Center, South Jordan

84025

Farmington Health Center, Farmington

84065

Riverton Hospital, Riverton

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84143

LDS Hospital, Salt Lake City

84321

Logan Regional Hospital, Logan

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center, Provo

84720

Sandra L Maxwell Cancer Center, Cedar City

84770

Saint George Regional Medical Center, St. George

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

90048

Cedars Sinai Medical Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92093

UC San Diego Moores Cancer Center, La Jolla

92354

Loma Linda University Medical Center, Loma Linda

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94143

UCSF Medical Center-Parnassus, San Francisco

95817

University of California Davis Comprehensive Cancer Center, Sacramento

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97045

Providence Willamette Falls Medical Center, Oregon City

97132

Providence Newberg Medical Center, Newberg

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97239

Oregon Health and Science University, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98109

FHCC South Lake Union, Seattle

Fred Hutchinson Cancer Center, Seattle

98112

Kaiser Permanente Washington, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98201

Providence Regional Cancer Partnership, Everett

98221

Cancer Care Center at Island Hospital, Anacortes

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99204

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown, Spokane

99216

MultiCare Deaconess Cancer and Blood Specialty Center - Valley, Spokane Valley

99218

MultiCare Deaconess Cancer and Blood Specialty Center - North, Spokane

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

99701

Fairbanks Memorial Hospital, Fairbanks

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

01420

Simonds-Sinon Regional Cancer Center, Fitchburg

01655

UMass Memorial Medical Center - University Campus, Worcester

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH