Carboplatin in EARLY Triple Negative Breast Cancer Trial (PEARLY Trial)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

878

Participants

Timeline

Start Date

September 1, 2015

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2025

Conditions
Breast Cancer
Interventions
DRUG

taxane plus carboplatin

"Doxorubicin (60 mg/m2) IV + cyclophosphamide (600 mg/m2) IV every 3 weeks for 4 cycles followed by taxane plus carboplatin for 4 cycles The taxane plus carboplatin regimen can be selected based on the investigator's discretion from among the following two regimens.~* Docetaxel (75 mg/m2) IV plus carboplatin (AUC 5) IV every 3 weeks for 4 cycles~* Paclitaxel (80 mg/m2) IV weekly for 12 doses plus carboplatin (AUC 5) IV every 3 weeks for 4 cycles"

DRUG

Taxane

"Doxorubicin (60 mg/m2) IV + cyclophosphamide (600 mg/m2) IV every 3 weeks for 4 cycles followed by taxane for 4 cycles The taxane regimen can be selected at the investigator's discretion from among the following two regimens.~* Docetaxel (75 mg/m2) IV every 3 weeks for 4 cycles~* Paclitaxel (80 mg/m2) IV weekly for 12 doses"

Trial Locations (21)

Unknown

Chungbuk university hospital, Cheonju

National Cancer Center, Goyang

National Health Insurance Service Ilsan Hospital, Ilsan

Bundang Cha Hospital, Seongnam

Ajou universwity Medical Center, Suwon

Soonchunhyang university Cheonan hospital, Cheonan

Inje University Haeundae Paik Hospital, Busan

Keimyung University Dongsan Medical Center, Daegu

Gachon University Gil Medical Center, Incheon

Seoul national university Bundang Hospital, Seongnam

Asan Medical Center, Seoul

Boramae Medical Center, Seoul

Catholic university of Korea, Seoul St. Mary's Hospital, Seoul

Chung Ang University Heaelthcare System, Seoul

Gangnam Severance hospital, Seoul

Korea University Anam hospital, Seoul

Kyunghee University Healthcare System, Seoul

Samsung Medical Center, Seoul

Yonsei Cancer Center at Yonsei University Medical Center, Seoul

Ulsan University Hospital, Ulsan

Wonju Severance Christian Hospital, Wŏnju

All Listed Sponsors
lead

Yonsei University

OTHER