Allogeneic Hematopoietic Stem Cell Transplantation (AlloSCT) Initial Salvage Therapy for Induction Failure Acute Myeloid Leukemia (AML)

Test dose Busulfan 32 mg/m2 given by vein on Day -8. Busulfan AUC 5,000 by vein on Days -6 to -3.

Fludarabine 10 mg/m2 by vein on Days -6 to -3.

"Salvage Chemotherapy Before Transplant: Clofarabine 15 mg/m2 by vein on Days 6 - 9.~Stem Cell Transplant: Clofarabine 40 mg/m2 by vein on Days -6 to -3."

Total body irradiation (TBI) delivered at 2Gy on Day -2.

Thymoglobulin 2.0 mg/Kg by vein on Days -3 and -2.

Fresh or cryopreserved bone marrow or peripheral blood (PB) progenitor cells infused on Day 0. Goal is to infuse 4 X 106 CD34+ cells/kg if PB or \>3.0 X 108 marrow mononuclear cells/kg if bone marrow.

Cyclophosphamide 50 mg/kg by vein on Days +3 and +4.

Tacrolimus 0.015 mg/kg/day by vein or mouth on Day +5.

Mycophenolate mofetil 15 mg/kg/dose by vein or by mouth three times a day from Day +5 to Day+100.

20 mg/m2 by vein on Days 1 - 5.

1 g/m2 by vein on Days 6 - 10.

10 mg/m2 by vein on Days 6 - 8.