NCT02429557View on ClinicalTrials.gov

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

PHASE1RecruitingINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

April 30, 2015

Primary Completion Date

December 15, 2025

Study Completion Date

December 31, 2025

Conditions
Orthostatic HypotensionPure Autonomic FailureMultiple System AtrophyAutonomic Failure
Interventions
OTHER

Abdominal compression

Abdominal compression of 40 mmHg with a commercial inflatable cuff applied during head up tilt

OTHER

Sham abdominal compression

Sham abdominal compression of 5 mmHg with a commercial inflatable cuff applied during head up tilt

DRUG

Placebo pill

Placebo pill given 1 hour before the second heat up tilt

DRUG

midodrine

Midodrine single dose 2.5-10mg PO given 1 hour before the second head up tilt

Trial Locations (1)

37232

RECRUITING

Vanderbilt University, Nashville

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Vanderbilt University Medical Center

OTHER