902
Participants
Start Date
June 23, 2015
Primary Completion Date
April 14, 2020
Study Completion Date
August 31, 2021
Atezolizumab (MPDL3280A), an engineered anti-PDL1 antibody
Atezolizumab at a fixed dose of 840 milligrams via intravenous (IV) infusion on Days 1 and 15 of each 28-day cycle until disease progression or unacceptable toxicity.
Nab-Paclitaxel
Nab-Paclitaxel at a starting dose of 100 milligrams per square meter via IV infusion on Days 1, 8, and 15 of each 28-day cycle. Nab-Paclitaxel was administered for a target of at least 6 cycles, with no maximum in the absence of disease progression or unacceptable toxicity.
Placebo
Placebo administered via IV infusion on Days 1 and 15 of each 28-day cycle until disease progression or unacceptable toxicity.
National Taiwan Uni Hospital; General Surgery, Taipei
China Medical University Hospital; Surgery, Taichung
Kaohsiung Medical Uni Chung-Ho Hospital; Dept of Surgery, Kaohsiung City
Institute of Oncology Ljubljana, Ljubljana
Institut Jules Bordet, Anderlecht
Medizinische Universität Wien; Univ.Klinik für Innere Medizin I, Vienna
Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly, Budapest
Fövárosi Önkormányzat uzsoki utcai Kórház, Budapest
Cliniques Universitaires St-Luc, Brussels
Chris O'Brien Lifehouse, Camperdown
Sint Augustinus Wilrijk, Wilrijk
Nepean Cancer Care Centre, Sydney
Peter MacCallum Cancer Centre; Medical Oncology, Melbourne
UZ Leuven Gasthuisberg, Leuven
Sunshine Hospital, St Albans
Peninsula and South Eastern Haematology and Oncology Group, Frankston
Ordensklinikum Linz Barmherzige Schwestern; Abt. fur Innere Medizin 1, Linz
Stavanger Universitetssykehus, Helse Stavanger HF, Stavanger
Universitaetsspital Basel; Onkologie, Basel
Icon Cancer Foundation, South Brisbane
Princess Alexandra Hospital; Division of Cancer Services, Woolloongabba
A.Ö. Lhk; Ii. Medizinische Abt. Mit Schwerpunkt Gaströnter. & Onkologie, Steyr
Sørlandet Sykehus Kristiansand, Kristiansand
Daugavpils Regional Hospital, Daugavpils
GHdC Site Notre Dame, Charleroi
St John of God Hospital; Bendat Cancer Centre, Subiaco
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Szeged
Clinic of Oncology, University Clinical Center Sarajevo, Sarajevo
Lkh-Univ. Klinikum Graz; Klinik Für Innere Medizin I, Graz
Universitätsspital Zürich, Zurich
AZ Groeninge, Kortrijk
Kantonsspital St.Gallen Brustzentrum/Chirurgie; Brustzentrum, Sankt Gallen
Laura and ISAAC Perlmutter Cancer Center at NYU Langone., New York
Clinica CIMCA, San José
ICIMED Instituto de Investigación en Ciencias Médicas, San José
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc, Bangkok
National Cancer Center, Goyang-si
Montefiore Medical Center, The Bronx
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology, Bangkok
Clinica del Country, Bogotá
ProHEALTH Care Associates LLP, Lake Success
North Estonia Medical Centre Foundation; Oncology Centre, Tallinn
Ambulantes Tumorzentrum Spandau; Dres. Benno Mohr und Uwe Peters, Berlin
Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba
Magee Womens Hospital, Pittsburgh
St. Luke's Cancer Care Associates, Bethlehem
MedStar Georgetown University Hospital (Lombardi Comprehensive Cancer Center), Washington D.C.
Irccs Istituto Europeo Di Oncologia (IEO); Ricerca Di Senologia Medica, Milan
Universitätsklinikum Hamburg-Eppendorf; Frauenklinik, Hamburg
Facharztzentrum Eppendorf, Studien GbR, Hamburg
Maryland Oncology Hematology, Rochville
Mercy Medical Center, Baltimore
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore
Inova Medical Group, Fairfax
Universitätsklinikum Schleswig-Holstein; Campus Lübeck, Lübeck
Hopital Jean Minjoz, Besançon
Instituto Estatal de Cancerologia Colima, Colima
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid
Hospital Universitario La Paz; Servicio de Oncologia, Madrid
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga
Greenville Health System (GHS) Cancer Institute, Greenville
Northwest Georgia Oncology Centers PC - Marietta, Marietta
Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy), Jacksonville
The Mount Siani Comprehensive Cancer Center, Miami Beach
Florida Cancer Research Institute, Plantation
Tampere University Hospital; Dept of Oncology, Tampere
Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building), St. Petersburg
Florida Cancer Specialists - SCRI; Pharmacy, Fort Myers
Istanbul University Cerrahpasa Medical Faculty; Radiation Oncology Department, Istanbul
Medipol University MF; Oncology Department, Istanbul
Institut régional du Cancer Montpellier, Montpellier
Ege Uni Medical Faculty Hospital; Oncology Dept, Izmir
University of Alabama at Birmingham, Birmingham
Sarah Cannon Cancer Center - Tennessee Oncology, Pllc, Nashville
Vanderbilt, Nashville
Wellmont Bristol Regional Medical Center, Bristol
HOPITAL MICHALLON - CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE, Service d'oncologie Médicale, Grenoble
West Clinic, Germantown
Jackson Oncology Associates, PLLC, Jackson
Treatment and Prevention Institution Volyn Regional Oncology Dispensary, Lutsk
The Mark H. Zangmeister Ctr; Mid Ohio Onc/Hem Inc., Columbus
Institut De Cancerologie De L'Ouest; Medical Oncology, Saint-Herblain
St. Johannes Hospital; Abt. für Hämatologie und Onkologie, Dortmund
Clinique Catherine de Sienne, Nantes
Uniklinik Essen; Gynäkologie, Essen
Onc/Hem Care Clin Trials LLC, Cincinnati
Oncologianova GmbH - Gesellschaft für Innovationen in der Onkologie, Recklinghausen
Instituto Valenciano Oncologia; Oncologia Medica, Valencia
Gemeinschaftspraxis für Hämatologie und Onkologie, Münster
Barbara Ann Karmanos Cancer Institute; Oncology, Detroit
Ico - Paul Papin, Angers
West Michigan Cancer Center, Kalamazoo
Chemotherapy SI Dnipropetrovsk MA of MOHU, Dnipropetrovsk
Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH, Georgsmarienhütte
St. Elisabeth-Krankenhaus; Brustzentrum, Cologne
Tartu Uni Hospital; Hematology - Oncology Clinic, Tartu
Dres. Helmut Forstbauer, Carsten Ziske und Kollegen; Onkologische Schwerpunktpraxis, Troisdorf
Mutterhaus der Borromäerinnen gGmbH, Abteilung Hämatologie-Onkologie, Trier
Praxis Köppler, Heymann, Weide, Thomalla; Fä Für Innere Medizin, Koblenz
Centre Oscar Lambret, Lille
Rush University Medical Center - Chicago, Chicago
Washington University School of Medicine, St Louis
Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC, Kansas City
Centro Médico Zambrano Hellion, Monterrey
Centre Paul Strauss, Strasbourg
Centre Leon Berard, Lyon
Universitatsklinik Heidelberg; Universitätshautklinik und Nationales Centrum für Tumorerkrankungen, Heidelberg
Universitätsklinik Tübingen; Frauenklinik & Poliklinik, Tübingen
Highlands Oncology Group, Springdale
Institut Curie, Paris
Hopital La Pitie Salpetriere, Paris
The Methodist Cancer Center, Houston
University of Texas;M.D. Anderson Cancer Center, Houston
Lviv State Oncology Regional Treatment and Diagnostic Centre, Lviv
Texas Oncology- El Paso Cancer Treatment Center Gateway, El Paso
Kaiser Permanente Of Colorado, Aurora
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica, Napoli
Klinikum rechts der Isar der TU München; Klinik und Poliklinik für Frauenheilkunde, München
Institut Sainte Catherine, Avignon
Songklanagarind Hospital; Department of Oncology, Songkhla
Universitätsklinikum Erlangen; Frauenklinik, Erlangen
Kaiser Permanente - San Marcos, San Marcos
Emad Ibrahim, Md, Inc, Redlands
Cancer Research Collaboration, Inc., Santa Ana
Univ of Calif, San Francisco; Breast Cancer Center, San Francisco
Kaiser Permanente of Northern California, Oakland
Kaiser Perm NW - Rheuma, Portland
Providence Cancer Center, Portland
Cancer Care Northwest, Spokane
MVZ Nordhausen gGmbH, Praxis Dr. Grafe, Nordhausen
Main Military Clinical Hospital named after N.N. Burdenko, Moscow
Blokhin Cancer Research Center; Combined Treatment, Moskva
National University Hospital, Singapore
Moscow City Oncology Hospital #62, Moscovskaya Oblast
Ivanovo Regional Oncology Dispensary, Ivanovo
Arkhangelsk Regional Clinical Oncology Dispensary, Arkhangelsk
National Cancer Centre, Singapore
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological), Saint Petersburg
Oncomedica S.A., Montería
Oncomed SRL, Timișoara
Clinical Oncology Dispensary of Ministry of Health of Tatarstan, Kazan'
Euromedical General Clinic of Thessaloniki; Oncology Department, Thessaloniki
Sociedad de Investigaciones Medicas Ltda (SIM), Temuco
Centro de Cancer Pontificie Universidad Catolica de Chile, Santiago
Stanford Univ School of Med; Oncology, Stanford
Yale Cancer Center; Medical Oncology, New Haven
Norwalk Hospital, Norwalk
Stamford Hospital; BCC, MOHR, Stamford
New Hampshire Hematology Oncology, Manchester
The Valley Hospital, Ridgewood
Centro de Oncologia e Investigacion Buenos Aires (COIBA), Buenos Aires
Fundación CENIT para la Investigación en Neurociencias, Buenos Aires
Centro Oncologico Riojano Integral (CORI), La Rioja
Crio - Centro Regional Integrado de Oncologia, Fortaleza
Santa Casa de Misericordia de Salvador, Salvador
Hospital Araujo Jorge; Departamento de Ginecologia E Mama, Goiânia
Hospital de Caridade de Ijui; Oncologia, Ijuí
Hospital das Clinicas - UFRGS, Porto Alegre
Hospital Sao Lucas - PUCRS, Porto Alegre
Centro de Pesquisas Oncologicas - CEPON, Florianópolis
Clinica de Neoplasias Litoral, Itajaí
Hospital Perola Byington, São Paulo
Hospital Sao Jose, São Paulo
Tom Baker Cancer Centre-Calgary, Calgary
Cross Cancer Institute ; Dept of Medical Oncology, Edmonton
BC Cancer - Kelowna (Sindi Ahluwalia Hawkins Centre), Kelowna
British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre, Vancouver
Queen Elizabeth II Health Sciences Centre; Oncology, Halifax
Kingston General Hospital, Kingston
Lakeridge Health Oshawa; Oncology, Oshawa
The Ottawa Hospital Cancer Centre, Ottawa
Sunnybrook Odette Cancer Centre, Toronto
Jewish General Hospital, Montreal
Hopital du Saint Sacrement, Québec
Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc
Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika, Prague
Fakultni nemocnice v Motole, Prague
"Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden", Dresden
Universitätsklinikum Halle (Saale); Universitätsklinik Und Poliklinik Für Gynäkologie, Halle
Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine, Athens
IASO General Hospital of Athens, Athens
Univ General Hosp Heraklion; Medical Oncology, Heraklion
University Hospital of Patras Medical Oncology, Pátrai
Grupo Angeles, Guatemala City
Queen Mary Hospital; Dept of Medicine, Hong Kong
Helse Bergen HF Haukeland universitetssjukehus kreftavdelingen poliklinikk, Bergen
Aichi Cancer Center Hospital, Aichi
Fukushima Medical University Hospital, Fukushima
Gunma Prefectural Cancer Center, Gunma
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
Hiroshima University Hospital, Hiroshima
National Hospital Organization Hokkaido Cancer Center, Hokkaido
Hyogo Medical University Hospital, Hyōgo
Sagara Hospital, Kagoshima
St. Marianna University Hospital, Kanagawa
Tokai University Hospital, Kanagawa
Kumamoto University Hospital, Kumamoto
Kyoto University Hospital, Kyoto
Mie University Hospital, Mie
Tohoku University Hospital, Miyagi
Niigata Cancer Center Hospital, Niigata
Okayama University Hospital, Okayama
Naha-nishi Clinic, Okinawa
National Hospital Organization Osaka National Hospital, Osaka
Osaka International Cancer Institute, Osaka
Kindai University Hospital, Osaka
Saitama Medical University International Medical Center, Saitama
Saitama Cancer Center, Saitama
Shizuoka Cancer Center, Shizuoka
National Cancer Center Hospital, Tokyo
St. Luke's International Hospital, Tokyo
Komagome Hospital, Tokyo
The Cancer Institute Hospital of JFCR, Tokyo
Riga East Clinical University Hospital Latvian Oncology Centre, Riga
Centro Medico Dalinde, Mexico City
Iem-Fucam, D.F.
Consultorio de Medicina Especializada; Dentro de Condominio San Francisco, Mexico City
Centro Oncológico de Panamá, Panama City
Centrum Onkologii w Bydgoszczy; Oddzial Kliniczny Onkologii, Bydgoszcz
Szpitale Wojewodzkie w Gdyni Sp. z o.o., Gdynia
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii, Krakow
Centrum Onkologii Ziemi LUBELSKIEJ im. Sw Jana z Dukli, I oddz. Chemioterapii, Lublin
Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad; Klinika Nowtw.Piersi i Chir.Rekonstr, Warsaw
Wojskowy Instytut Medyczny, Warsaw
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hospital del Mar; Servicio de Oncologia, Barcelona
Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona
Hospital Duran i Reynals; Oncologia, Barcelona
Sodersjukhuset; Onkologkliniken, Stockholm
Akademiska sjukhuset, Onkologkliniken, Uppsala
VETERANS GENERAL HOSPITAL; Department of General Surgery, Taipei
Cukurova Uni Faculty of Medicine; Medical Oncology, Adana
Hacettepe Uni Medical Faculty Hospital; Oncology Dept, Sihhiye/Ankara
Kyiv City Clinical Oncological Center, Kyiv
Velindre Cancer Centre, Cardiff
Western General Hospital; Clinical Oncology, Edinburgh
St Bartholomew's Hospital, London
Guys ST Thomas Hospital, London
Royal Marsden Hospital - London, London
Christie Hospital Nhs Trust; Medical Oncology, Manchester
Derriford Hospital, Plymouth
Royal Preston Hosptial, Preston
Weston Park Hospital, Sheffield
Royal Marsden Hospital; Dept of Medical Oncology, Sutton
Hoffmann-La Roche
INDUSTRY