Timing for Bone Marrow Mononuclear Cells After Acute Myocardial Infarction

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

104

Participants

Timeline

Start Date

February 28, 2005

Primary Completion Date

August 31, 2006

Study Completion Date

August 31, 2006

Conditions
Myocardial Infarction
Interventions
OTHER

BMC therapy within 24 hours

The BMCs were isolated by Ficoll density gradient centrifugation on Lymphocyte Separation Medium. BMCs were infused into IRA at the site of the previous occlusion. This was accomplished with the use of a microtubular. After positioning of the microtubular into the distal segment vessel of the stent position in the infarct-related artery, 15 milliliter of the whole cell suspension was slowly administered via microtubular. The usual time should be over 10min to prevent back-flow and to prolong cellular contact time for cellular migration into the tissue. Patients in BMC therapy group within 24 hours remained in the cath-lab until the entire procedure, including primary PCI and intracoronary BMC infusion, was completed.

OTHER

BMC therapy within 3-7 days

Patients in this group, who underwent a second procedure, to receive BMC transplantation in the cath-lab during the same hospitalization or returned for a second hospitalization.

OTHER

BMC therapy within 7-30 days

Patients in this group, who underwent a second procedure, to receive BMC transplantation in the cath-lab during the same hospitalization or returned for a second hospitalization.

OTHER

PCI only

The saline was intracoronary infusion with the use of microtubular.

All Listed Sponsors
collaborator

Fudan University

OTHER

lead

The First Affiliated Hospital of Dalian Medical University

OTHER

NCT02425358 - Timing for Bone Marrow Mononuclear Cells After Acute Myocardial Infarction | Biotech Hunter | Biotech Hunter