Study of Gemcitabine/Carboplatin First-line Chemotherapy +/- Apatorsen in Advanced Squamous Cell Lung Cancers

PHASE2UnknownINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

June 30, 2014

Primary Completion Date

May 31, 2018

Study Completion Date

June 30, 2018

Conditions
Squamous Cell Lung Cancer
Interventions
DRUG

Apatorsen (OGX-427)

Apatorsen (OGX-427) is a second generation antisense oligonucleotide designed to bind to Hsp27 mRNA

DRUG

Gemcitabine

"Gemcitabine is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. Gemcitabine is classified as an antimetabolite"

DRUG

Carboplatin

"Carboplatin is an anticancer drug (antineoplastic or cytotoxic) chemotherapy drug. Carboplatin is classified as an alkylating agent."

Trial Locations (20)

TR1 3LQ

Royal Cornwall Hospitals NHS Trust, Truro

ME7 5NY

Medway NHS Foundation Trust, Gillingham

B9 5SS

Heart of England NHS Foundation Trust, Birmingham

BS2 8ED

University Hospitals Bristol NHS Foundation Trust, Bristol

CF14 2TL

Velindre Cancer Centre, Cardiff

CO3 3NB

Colchester Hospital University NHs Foundation Trust, Colchester

LL18 5UJ

Betsi Cadwaladr University Health Board, Denbighshire

DD2 1UB

NHS Tayside, Dundee

GU2 7XX

Royal Surrey County Hospital NHS Foundation Trust, Guildford

IV2 3UJ

NHS Highland, Inverness

EC1M 6BQ

Barts Health NHS Trust, London

NW1 2PG

University College London Hospitals NHS Foundation Trust, London

NW3 2QG

Royal Free London NHS Foundation Trust, London

SE13 6LH

Lewisham and Greenwich NHS Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

NG5 1PB

Nottingham University Hospitals NHS Trust, Nottingham

RG1 5AN

Royal Berkshire NHS Foundation Trust, Reading

SA2 8QA

Abertawe Bro Morgannwg University Health Board, Swansea

BS23 4TQ

Weston Area Health NHS Trust, Weston-super-Mare

BA21 4AT

Yeovil District Hospital NHS Foundation Trust, Yeovil

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Achieve Life Sciences

INDUSTRY

lead

Queen Mary University of London

OTHER