Genomic Sequencing for Childhood Risk and Newborn Illness

NACompletedINTERVENTIONAL
Enrollment

1,205

Participants

Timeline

Start Date

May 31, 2015

Primary Completion Date

April 30, 2020

Study Completion Date

August 5, 2021

Conditions
Hereditary DiseaseGenetic Predisposition to Disease
Interventions
GENETIC

Genomic sequencing

Both sick and healthy infants randomized to receive genomic sequencing will receive a 'Genomic Newborn Sequencing Report' (GNSR) which will include pathogenic or likely pathogenic variants identified in genes associated with childhood-onset disease.

OTHER

Family history report

Participants from all arms of the study will have a family history taken by a study genetic counselor. Information collected through the family history will be summarized in a family history report that will be reviewed with all participants.

Trial Locations (2)

02115

Boston Children's Hospital, Boston

Brigham and Women's Hospital, Boston

All Listed Sponsors
collaborator

Boston Children's Hospital

OTHER

collaborator

Baylor College of Medicine

OTHER

collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

collaborator

National Human Genome Research Institute (NHGRI)

NIH

collaborator

Massachusetts General Hospital

OTHER

lead

Brigham and Women's Hospital

OTHER

NCT02422511 - Genomic Sequencing for Childhood Risk and Newborn Illness | Biotech Hunter | Biotech Hunter