A Study of Atezolizumab in Combination With Bevacizumab Versus Sunitinib in Participants With Untreated Advanced Renal Cell Carcinoma (RCC)

PHASE3CompletedINTERVENTIONAL
Enrollment

915

Participants

Timeline

Start Date

May 20, 2015

Primary Completion Date

February 14, 2020

Study Completion Date

December 13, 2021

Conditions
Renal Cell Carcinoma
Interventions
DRUG

Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody

Atezolizumab will be administered at a fixed dose of 1200 milligrams (mg) via intravenous (IV) infusion on Days 1 and 22 of each 42-day cycle.

DRUG

Bevacizumab

Bevacizumab will be administered at a dose of 15 milligrams per kilogram (mg/kg) via IV infusion on Days 1 and 22 of each 42-day cycle.

DRUG

Sunitinib

Sunitinib will be administered at a dose of 50 mg once daily, orally via capsule, on Day 1 through Day 28 of each 42-day cycle.

Trial Locations (154)

100

National Taiwan Uni Hospital; Dept of Oncology, Taipei

333

Chang Gung Medical Foundation-Linkou, Urinary Oncology, Taoyuan District

407

Taichung Veterans General Hospital; Division of Urology, Taichung

2050

Lifehouse, Camperdown

2109

Macquarie University Hospital, Macquarie Park

2298

Calvary Mater Newcastle; Medical Oncology, Waratah

2730

Herlev Hospital; Afdeling for Kræftbehandling, Herlev

3084

Austin Hospital; Medical Oncology, Heidelberg

4101

Icon Cancer Foundation, South Brisbane

5000

Odense Universitetshospital, Onkologisk Afdeling R, Odense C

5037

Ashford Cancer Center Research, Kurralta Park

6150

St John of God Hospital, Murdoch

8200

Aarhus Universitetshospital; Kræftafdelingen, Aarhus N

8208

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell

10065

Memorial Sloan-Kettering Cancer Center, New York

10330

Chulalongkorn Hospital; Medical Oncology, Bangkok

10400

Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc, Bangkok

10408

National Cancer Center, Goyang-si

10700

Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology, Bangkok

12208

New York Oncology Hematology,P.C.-Albany, Albany

13273

Institut Paoli Calmettes; Oncologie Medicale, Marseille

13620

Seoul National University Bundang Hospital, Seongnam-si

14004

Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba

14076

Centre Francois Baclesse; Urologie Gynecologie, Caen

20132

Irccs Ospedale San Raffaele;Oncologia Medica, Milan

20162

Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia, Milan

22770

Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department, Edirne

24014

Oncology and Hematology Associates of SW Virginia-Raonoke, Roanoke

27100

Fondazione IRCCS Policlinico San Matteo, Oncologia, Pavia

28007

Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid

28034

Hospital Ramon y Cajal; Servicio de Oncologia, Madrid

28041

Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid

30318

Piedmont Cancer Institute, PC, Atlanta

33075

Hopital Saint Andre; Oncologie 2, Bordeaux

33486

Lynn Cancer Institute/Boca Raton Regional Hospital, Boca Raton

33705

Florida Cancer Specialist, North Region, St. Petersburg

33980

Florida Cancer Specialists - Port Charlotte, Port Charlotte

34300

Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology, Istanbul

35015

Chungnam National University Hospital, Daejeon

37203

Sarah Cannon Cancer Center and Research Institute, Nashville

37232

Vanderbilt Univ Medical Ctr, Nashville

37404

SCRI Tennessee Oncology Chattanooga, Chattanooga

40202

Norton Cancer Institute, Louisville

41013

Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Seville

41100

A.O. Universitaria Policlinico Di Modena; Oncologia, Modena

44195

Cleveland Clinic Foundation; Taussig Cancer Center, Cleveland

44805

ICO - Site René Gauducheau, Saint-Herblain

45122

Universitätsklinikum Essen; Innere Klinik und Poliklinik für Tumorforschung, Essen

45242

Oncology Hematology Care Inc, Cincinnati

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola

49055

ICO Paul Papin; Oncologie Medicale., Angers

50180

Centro Oncologico Estatal ISSEMYM, Toluca

50200

Maharaj Nakorn Chiangmai Hospital; Department of Surgery/ Urology unit, Chiang Mai

52100

Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato;U.O.C. Oncologia, Arezzo

54100

Centre D'Oncologie de Gentilly; Oncology, Nancy

59020

Centre Oscar Lambret, Lille

60637

The University of Chicago, Chicago

69120

Nationales Centrum für Tumorerkrankungen Heidelberg (NCT); Thoraxklinik Heidelberg, Heidelberg

69373

Centre Léon Bérard, Lyon

72076

Universitätsklinikum Tübingen; Klinik für Urologie, Tübingen

75246

Texas Oncology-Baylor Sammons Cancer Center, Dallas

75475

APHP - Hospital Saint Louis, Paris

75908

Hopital Europeen Georges Pompidou; Service D'Oncologie Medicale, Paris

76090

Cancerología, Querétaro

78000

University Clinical Centre of the Republic of Srpska, Banja Luka

80045

University of Colorado; Anschutz Cancer Pavilion, Aurora

80131

Az. Osp. Cardarelli; Divisione Di Oncologia, Napoli

80303

Rocky Mountain Cancer Center; Medical Oncology, Boulder

81377

Klinikum d.Universität München Campus Großhadern, München

85719

University of Arizona Cancer Center, Tucson

89169

Comprehensive Cancer Centers of Nevada - Eastern Avenue, Las Vegas

90110

Songklanagarind Hospital; Department of Oncology, Songkhla

92868

University of California at Irvine Medical Center; Department of Oncology, Orange

94158

University of California, San Francisco

94805

Institut Gustave Roussy; Departement Oncologie Medicale, Villejuif

97223

Northwest Cancer Specialists, P.C., Tigard

98109

Seattle Cancer Care Alliance, Seattle

117599

National University Hospital, Singapore

125284

P.A. Herzen Oncological Inst. ; Oncology, Moscow

143423

City Clinical Oncology Hospital, Moscow

169610

National Cancer Centre; Medical Oncology, Singapore

603001

GBUZ Nizhegorodskay Region: Clinical Diagnostic Center, Nizhny Novgorod

656049

"ALTAI REGIONAL ONCOLOGICAL CENTER; Nadezhda Clinic", Barnaul

20016-1468

Georgetown U; Lombardi Comp Can, Washington D.C.

02114

Massachusetts General Hospital, Boston

02115

Dana Farber Cancer Inst., Boston

02215

Beth Israel Deaconess Medical Center, Boston

07601

Hackensack University Medical Center, Hackensack

98700-000

Hospital de Caridade de Ijui; Oncologia, Ijuí

90050-170

Santa Casa de Misericordia de Porto Alegre, Porto Alegre

90610-000

Hospital Sao Lucas - PUCRS, Porto Alegre

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo

B3H 2Y9

Queen Elizabeth II Health Sciences Centre; Oncology, Halifax

L4M 6M2

Royal Victoria Hospital, Barrie

L8V 5C2

Hamilton Health Sciences - Juravinski Cancer Centre, Hamilton

N6A 4L6

London Regional Cancer Centre, London

L1G 2B9

Lakeridge Health Oshawa; Oncology, Oshawa

K1H 8L6

The Ottawa Hospital Cancer Centre; Oncology, Ottawa

M4N 3M5

Sunnybrook Odette Cancer Centre, Toronto

M5G 1Z5

Princess Margaret Cancer Center, Toronto

H3T 1E2

Jewish General Hospital, Montreal

G1R 2J6

CHU de Quebec Hotel-Dieu de Quebec, Québec

656 53

Masarykuv onkologicky ustav, Brno

779 00

Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc

128 08

Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika, Prague

140 59

Thomayerova nemocnice, Praha 4 - Krc

01307

"Universitätsklinikum Carl Gustav Carus; Klinik und Poliklinik für Urologie", Dresden

00152

Azienda Ospedaliera San Camillo Forlanini; Oncologia Medica, Rome

466-8560

Nagoya University Hospital; Urology, Aichi

260-8717

Chiba Cancer Center, Chiba

812-8582

Kyushu University Hospital, Fukuoka

371-8511

Gunma University Hospital, Gunma

060-8648

Hokkaido University Hospital, Hokkaido

305-8576

University of Tsukuba Hospital; Urology, Ibaraki

236-0004

Yokohama City University Hospital, Kanagawa

252-0375

Kitasato University Hospital, Kanagawa

860-8556

Kumamoto University Hospital, Kumamoto

951-8520

Niigata University Medical & Dental Hospital, Niigata

028-3695

Iwate Medical University Hospital, Numakunai

700-8558

Okayama University Hospital, Okayama

541-8567

Osaka International Cancer Institute; Urology, Osaka

545-8586

Osaka Metropolitan University Hospital, Osaka

565-0871

Osaka University Hospital, Osaka

589-8511

Kindai University Hospital, Osaka

770-8503

Tokushima University Hospital, Tokushima

105-8470

Toranomon Hospital, Tokyo

113-8519

Tokyo Medical and Dental University Hospital, Tokyo

113-8603

Nippon Medical School Hospital, Tokyo

135-8550

The Cancer Institute Hospital, JFCR; Urology, Tokyo

160-8582

Keio University Hospital, Tokyo

162-0054

Tokyo Women's Medical University, Tokyo

20-090

Centrum Onkologii Ziemi Lubelskiej im. św. Jana z Dukli, Lublin

60-569

Szpital Kliniczny; Przemienienia Panskiego;Uniwersytetu Medyczny im.; Karola Marcinkowskiego w Pozna, Poznan

02-616

Saint Elizabeth's Hospital, Warsaw

04-125

MAGODENT Sp. z o.o., Warsaw

003-722

Severance Hospital, Yonsei University Health System, Seoul

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

135-710

Samsung Medical Center, Seoul

08035

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona

08036

Hospital Clínic i Provincial; Servicio de Oncología, Barcelona

08907

Hospital Duran i Reynals; Oncologia, Barcelona

06100

Hacettepe University Medical Faculty, Ankara

CH63 4JY

Clatterbridge Cancer Centre, Bebington

B15 2TH

Queen Elizabeth Hospital, Birmingham

BB2 3HH

Royal Blackburn Hospital, Blackburn

CB2 0QQ

Addenbrookes Nhs Trust; Oncology Clinical Trials Unit, Cambridge

EC1A 7BE

Barts Health NHS Trust - St Bartholomew's Hospital, London

NW3 2QG

Royal Free Hospital; Dept of Oncology, London

M2O 4BX

Christie Hospital Nhs Trust; Medical Oncology, Manchester

OX3 7LJ

Churchill Hospital; Oxford Cancer and Haematology Centre, Oxford

SO16 6YD

Southampton General Hospital; Medical Oncology, Southampton

SM2 5PT

Royal Marsden Hospital; Dept of Medical Oncology, Sutton

SA2 8QA

Singleton Hospital; Pharmacy Department, Swansea

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02420821 - A Study of Atezolizumab in Combination With Bevacizumab Versus Sunitinib in Participants With Untreated Advanced Renal Cell Carcinoma (RCC) | Biotech Hunter | Biotech Hunter