Empagliflozin as Adjunctive to InSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)

PHASE3CompletedINTERVENTIONAL
Enrollment

730

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

April 20, 2017

Study Completion Date

October 23, 2017

Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG

Empagliflozin

DRUG

Empagliflozin

DRUG

Placebo

Trial Locations (131)

100

National Taiwan University Hospital, Taipei

402

Chung Shan Medical University Hospital, Taichung

710

Chi Mei Medical Center, Tainan City

1030

KH Rudolfstiftung, 1. Med. Abt., Wien, Vienna

1070

ULB Hopital Erasme, Brussels

1090

Brussels - UNIV UZ Brussel, Brussels

1130

Hospital Hietzing, Vienna

2170

Merksem - HOSP ZNA Jan Palfijn, Merksem

2291

AIM Centre, Merewether

2450

Coffs Endocrine & Diabetes Services, Coffs Harbour

2650

Edegem - UNIV UZ Antwerpen, Edegem

2820

Bonheiden - HOSP Imelda, Bonheiden

Steno Diabetes Center Copenhagen, Gentofte Municipality

3000

UZ Leuven, Leuven

3400

Nordsjællands Hospital - Hillerød, Hillerød

4000

Centre Hospitalier Universitaire de Liège, Liège

Liège - HOSP CHR de la Citadelle, Liège

4006

Royal Brisbane & Women's Hospital-Endocrinology, Herston

4400

LKH Steyr, Kardiologie, Steyr

4600

Køge Sygehus, Køge

6700

Arlon - HOSP Sud Luxembourg - Vivalia, Arlon

6807

VIVIT Instit.am LKH Feldkirch,Abt.f.Innere Med.u.Kardiologie, Feldkirch

7100

La Louvière - UNIV CHU Tivoli, La Louvière

8000

Aarhus Universitets Hospital, Aarhus C

9000

UNIV UZ Gent, Ghent

9100

Aalborg Sygehus Syd, Aalborg

10115

ikfe - Institut für klinische Forschung und Entwicklung Berlin GmbH, Berlin

10301

University Physicians Group Research Division, Staten Island

11100

HOP de Narbonne, diabéto endo, Narbonne, Narbonne

11490

Tri-Service General Hospital, Taipei

12206

Albany Medical Center / Albany Medical College, Albany

14033

HOP Côte de Nacre, Caen

17000

HOP Saint-Louis, La Rochelle

18004

Hospital de la Inmaculada Concepción, Granada

26610

NZOZ Centrum Medyczne AESKULAP,Private Prac, Radom, Radom

28557

Diabetes and Endocrinology Consultants, PC, Morehead City

29010

Hospital Virgen de la Victoria, Málaga

30046

Physicians Research Associates, LLC, Lawrenceville

30076

Endocrine Research Solutions, Inc., Roswell

31011

Dobry Lekarz,Spec.Med.Clinics,Private Prac,Krakow, Krakow

32204

East Coast Institute for Research, LLC, Jacksonville

33156

Baptist Diabetes Associates, PA, Miami

33312

The Center for Diabetes and Endocrine Care, Fort Lauderdale

35614

Gemeinschaftspraxis, Asslar, Aßlar

37212

Diabetes and Obesity Clinical Trials Center, Nashville

40002

Hospital General de Segovia, Segovia

40447

China Medical University Hospital, Taichung

41014

Hospital Nuestra Señora de Valme, Seville

41071

Hospital Virgen Macarena, Seville

45136

InnoDiab Forschung GmbH, Essen

45219

The Carl and Edyth Lindner Center for Research & Education at The Christ Hospital, Cincinnati

50265

Iowa Diabetes and Endocrinology Research Center, West Des Moines

51092

HOP Robert Debré, Reims

54511

HOP de Brabois, Vandœuvre-lès-Nancy

60005

Northwest Endo Diabetes Research, LLC, Arlington Heights

60012

Midwest Endocrinology, Crystal Lake

63739

Studienzentrum Aschaffenburg, Aschaffenburg

66121

Praxis Dr. Hirschhäuser, Saarbrücken

66386

Praxis Dr. Segner, St. Ingbert, Saint Ingbert/Oberwürzbach

66780

Allgemeinmedizinische und Diabetologische Schwerpunktpraxis, Rehlingen-Siersburg

68114

Diabetes anddocrine Associates, PC, Omaha

69200

HOP les Portes du Sud, Diabéto, Vénissieux, Vénissieux

75231

North Texas Endocrine Center, Dallas

77090

Office of Dr. Michelle Zaniewski-Singh, Houston

78681

Texas Diabetes and Endocrinology, Round Rock

80246

Creekside Endocrine Associates, PC, Denver

83404

Rocky Mountain Diabetes and Osteoporosis Center, Idaho Falls

84102

Bateman Horne Center, Salt Lake City

84405

Advanced Research Institute, South Ogden

89052

Desert Endocrinology Clinical Research Center, Henderson

89148

Palm Research Center, Las Vegas

90057

National Research Institute, Los Angeles

91356

Metabolic Institute of America, Tarzana

92025

AMCR Institute, Inc., Escondido

92648

Diabetes/Lipid Management and Research Center, Huntington Beach

92780

University Clinical Investigators, Inc., Tustin

94401

Mills-Peninsula Health Services, San Mateo

97421

Ambulanzzentrum Schweinfurt, Schweinfurt

98003

Larry D Stonesifer, MD Inc., PS, Federal Way

98057

Rainier Clinical Research Center, Inc, Renton

98104

The Polyclinic, Seattle

98405

MultiCare Institute for Research and Innovation, Tacoma

03063

Southern New Hampshire Diabetes and Endocrinology, Nashua

T2H 2G4

LMC Endocrinology Centres (Calgary) Ltd., Calgary

T4N 6V7

The Bailey Clinic, Red Deer

V8R 1J8

Royal Jubilee Hospital, Victoria

R3E 3P4

Health Sciences Centre Winnipeg, Winnipeg

Quebec

CHUM - Pavillon R, Montreal

B3H 1V7

Capital District Health Auth., Halifax

K7L 2V7

Kingston General Hospital, Kingston

L4J 8L7

LMC Thornhill/Vaughan, Thornhill

M5T 3L9

Mount Sinai Hospital, Toronto

H3A 1A1

Royal Victoria Hospital, Montreal

128 08

General Univ.hosp.in Prague (VFN), Diabetes ambulance, Prague

274 01

Diabetology and Internal Practice Dr. Vladimir Lelek, Slaný

401 13

Masaryk Hospital, Internal Department, Ústí nad Labem

FI-70100

IteLasaretti, Kuopio

FI-90100

Terveystalo Oulu, Diapolis, Oulu

FI-20520

TYKS, Turku

01796

Praxis Dr. Kosch, Pirna, Pirna

1815 JD

Noordwest Ziekenhuisgroep, Alkmaar

1105 AZ

Academisch Medisch Centrum (AMC), Amsterdam

6815 AD

Rijnstate Hospital, Arnhem

9728 NT

Martini Ziekenhuis, Groningen

7909 AA

Bethesda Ziekenhuis Hoogeveen, Hoogeveen

3045 PM

Sint Franciscus Gasthuis, Rotterdam

3331 LZ

Albert Schweitzer Ziekenhuis, Zwijndrecht, Zwijndrecht

N-6026

Helse Møre og Romsdal HF, Ålesund sjukehus, Ålesund

N-2318

Sykehuset Innlandet HF, Avd. Hamar, Hamar

N-1478

Akershus Universitetssykehus HF, Lørenskog

N-0424

Oslo Universitetssykehus HF, Aker Sykehus, Oslo

15-276

Med Univ Bialystok Clin Dep Endocrinol, Diabetol & Int Dis, Bialystok

15-435

NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny, Bialystok

20-538

"NZOZ Specialized Ambulance MEDICA", Lublin

60-834

Marcinkowski Poznan Univ of Med Sci, Clin Dept Diab, Poznan, Poznan

35-055

Centrum Medyczne Medyk, Rzeszów

00-465

NBR Polska, Warsaw

08025

C.A.P. Sardenya, Barcelona

08035

Hospital Vall d'Hebron, Barcelona

506 30

Ladulaas Kliniska Studier, Borås

651 85

Centralsjukhuset, Karlstad, Karlstad

162 68

Läkarhuset, Vällingby, Vällingby

MK65LD

Milton Keynes Hospital, Buckinghamshire

CB2 0QQ

Addenbrooke's Hospital, Cambridge

EH4 2XU

Wellcome Trust Clinical Research Facility, Edinburgh

LE5 4PW

Leicester General Hospital, Leicester

E1 1BB

Royal London Hospital, London

NG7 2UH

Queen's Medical Centre, Nottingham

CV10 7DJ

George Eliot Hospital, Nuneaton

RH1 5RH

East Surrey Hospital, Surrey

AL7 4HQ

Queen Elizabeth II Hospital, Welwyn Garden City

Sponsors
All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

Boehringer Ingelheim

INDUSTRY