1,902
Participants
Start Date
April 27, 2015
Primary Completion Date
July 29, 2017
Study Completion Date
November 23, 2017
Dupilumab
Solution for injection, Subcutaneous injection in the abdomen, upper thigh or upper arm.
Placebo
Solution for injection, Subcutaneous injection in the abdomen, upper thigh or upper arm.
Inhaled corticosteroid (ICS) therapy
Oral inhalation, stable dose (medium or high dose) of ICS in combination with up to 2 other controller medicines (second or third controller therapy)
Albuterol/Salbutamol
Oral inhalation as needed
Levalbuterol/Levosalbutamol
Oral inhalation as needed
Investigational Site Number 152015, Concepción
Investigational Site Number 158006, Taoyuan District
Investigational Site Number 158004, Kaohsiung City
Investigational Site Number 032011, Caba
Investigational Site Number 348003, Gödöllö
Investigational Site Number 036005, Campbelltown
Investigational Site Number 036004, Parkville
Investigational Site Number 036001, Clayton
Investigational Site Number 036002, Frankston
Investigational Site Number 710005, Durban
Investigational Site Number 710006, Durban
Investigational Site Number 036006, Glen Osmond
Investigational Site Number 036003, Murdoch
Investigational Site Number 710011, Cape Town
Investigational Site Number 710004, Cape Town
Investigational Site Number 710001, Cape Town
Investigational Site Number 710002, Cape Town
Investigational Site Number 710010, Cape Town
Investigational Site Number 710003, Cape Town
Investigational Site Number 710009, Winnie Mandela
Investigational Site Number 840065, New York
Investigational Site Number 158001, Taipei
Investigational Site Number 380011, Torino
Investigational Site Number 840031, The Bronx
Investigational Site Number 276006, Berlin
Investigational Site Number 158009, Taipei
Investigational Site Number 840106, Jamaica
Investigational Site Number 410014, Uijeongbu-si
Investigational Site Number 250010, Marseille
Investigational Site Number 410002, Bucheon-si
Investigational Site Number 840076, Rochester
Investigational Site Number 840028, Pittsburgh
Investigational Site Number 840091, Pittsburgh
Investigational Site Number 276005, Rüdersdorf
Investigational Site Number 724006, Santiago de Compostela
Investigational Site Number 792003, Bursa
Investigational Site Number 410001, Suwon
Investigational Site Number 840085, Hershey
Investigational Site Number 840081, Philadelphia
Investigational Site Number 840010, Philadelphia
Investigational Site Number 840067, Philadelphia
Investigational Site Number 840017, Chevy Chase
Investigational Site Number 840073, Gaithersburg
Investigational Site Number 804012, Vinnytsia
Investigational Site Number 840127, White Marsh
Investigational Site Number 840080, Baltimore
Investigational Site Number 410013, Incheon
Investigational Site Number 840059, Fairfax
Investigational Site Number 840113, Richmond
Investigational Site Number 276007, Lübeck
Investigational Site Number 158008, New Taipei City
Investigational Site Number 840003, Papillion
Investigational Site Number 840007, High Point
Investigational Site Number 840107, Greensboro
Investigational Site Number 840108, Durham
Investigational Site Number 724005, Pozuelo de Alarcón
Investigational Site Number 840126, Charlotte
Investigational Site Number 840083, Charlotte
Investigational Site Number 410003, Cheongju-si
Investigational Site Number 840054, Spartanburg
Investigational Site Number 840082, Charleston
Investigational Site Number 840117, Greenville
Investigational Site Number 250002, Brest
Investigational Site Number 840100, Greer
Investigational Site Number 840084, Gainesville
Investigational Site Number 276004, Hanover
Investigational Site Number 484013, Chihuahua City
Investigational Site Number 484006, Chihuahua City
Investigational Site Number 840044, Savannah
Investigational Site Number 840122, Hialeah
Investigational Site Number 792002, Mersin
Investigational Site Number 840114, South Miami
Investigational Site Number 840069, Miami
Investigational Site Number 840037, Aventura
Investigational Site Number 840053, Loxahatchee Groves
Investigational Site Number 840018, Boynton Beach
Investigational Site Number 840105, Brandon
Investigational Site Number 840048, Tampa
Investigational Site Number 840092, Clearwater
Investigational Site Number 484008, Durango
Investigational Site Number 792001, Istanbul
Investigational Site Number 840055, Sarasota
Investigational Site Number 250005, Montpellier
Investigational Site Number 840123, Ocala
Investigational Site Number 840071, Ocala
Investigational Site Number 792007, Istanbul
Investigational Site Number 840115, Ocoee
Investigational Site Number 792005, Izmir
Investigational Site Number 792010, Izmir
Investigational Site Number 840047, Birmingham
Investigational Site Number 804002, Poltava
Investigational Site Number 158005, Taichung
Investigational Site Number 158007, Taichung
Investigational Site Number 840032, Fort Mitchell
Investigational Site Number 724008, Seville
Investigational Site Number 792011, Kocaeli
Investigational Site Number 380002, Modena
Investigational Site Number 380014, Reggio Emilia
Investigational Site Number 840009, Owensboro
Investigational Site Number 840042, Toledo
Investigational Site Number 250003, Nantes
Investigational Site Number 484001, Guadalajara
Investigational Site Number 380003, Ferrara
Investigational Site Number 840049, Middleburg Heights
Investigational Site Number 276003, Bochum
Investigational Site Number 484015, Zapopan
Investigational Site Number 840046, Cincinnati
Investigational Site Number 804014, Ternopil
Investigational Site Number 724007, Valencia
Investigational Site Number 804023, Dnipro
Investigational Site Number 410015, Busan
Investigational Site Number 380006, Florence
Investigational Site Number 840089, Iowa City
Investigational Site Number 792006, Rize
Investigational Site Number 250014, Vandœuvre-lès-Nancy
Investigational Site Number 484014, Cuautitlán Izcalli
Investigational Site Number 276001, Mainz
Investigational Site Number 840005, Minneapolis
Investigational Site Number 276009, Koblenz
Investigational Site Number 380001, Pisa
Investigational Site Number 804007, Chernivtsi
Investigational Site Number 250013, Lille
Investigational Site Number 250011, Lille
Investigational Site Number 840026, Missoula
Investigational Site Number 380004, Ancona
Investigational Site Number 840015, River Forest
Investigational Site Number 276010, Frankfurt am Main
Investigational Site Number 840101, Chicago
Investigational Site Number 804005, Kharkiv
Investigational Site Number 804021, Kharkiv
Investigational Site Number 804001, Kharkiv
Investigational Site Number 840002, St Louis
Investigational Site Number 840093, St Louis
Investigational Site Number 840013, Kansas City
Investigational Site Number 484003, Monterrey
Investigational Site Number 484004, Mexico City
Investigational Site Number 804006, Odesa
Investigational Site Number 484007, Monterrey
Investigational Site Number 250008, Strasbourg
Investigational Site Number 840078, Omaha
Investigational Site Number 804022, Zaporizhia
Investigational Site Number 250004, Lyon
Investigational Site Number 380010, Foggia
Investigational Site Number 792009, Kırıkkale
Investigational Site Number 840132, Little Rock
Investigational Site Number 840112, Edmond
Investigational Site Number 840121, Oklahoma City
Investigational Site Number 840104, Tulsa
Investigational Site Number 250012, Paris
Investigational Site Number 250001, Paris
Investigational Site Number 840070, McKinney
Investigational Site Number 840128, McKinney
Investigational Site Number 840118, Plano
Investigational Site Number 840008, Dallas
Investigational Site Number 840094, Dallas
Investigational Site Number 804004, Ivano-Frankivsk
Investigational Site Number 804009, Ivano-Frankivsk
Investigational Site Number 840022, Fort Worth
Investigational Site Number 840027, Fort Worth
Investigational Site Number 840066, Killeen
Investigational Site Number 484012, San Juan del Río
Investigational Site Number 840119, Spring
Investigational Site Number 840124, Cypress
Investigational Site Number 840133, Sealy
Investigational Site Number 840038, Boerne
Investigational Site Number 840012, San Antonio
Investigational Site Number 840050, Live Oak
Investigational Site Number 840129, San Antonio
Investigational Site Number 840098, Austin
Investigational Site Number 840062, Amarillo
Investigational Site Number 840023, El Paso
Investigational Site Number 840004, Centennial
Investigational Site Number 840034, Denver
Investigational Site Number 840130, Denver
Investigational Site Number 840025, Colorado Springs
Investigational Site Number 158002, Kaohsiung City
Investigational Site Number 840079, Twin Falls
Investigational Site Number 840035, Draper
Investigational Site Number 840077, Murray
Investigational Site Number 840099, Gilbert
Investigational Site Number 840087, Scottsdale
Investigational Site Number 840056, Flagstaff
Investigational Site Number 840011, Los Angeles
Investigational Site Number 840061, Los Angeles
Investigational Site Number 840097, Los Angeles
Investigational Site Number 380009, Palermo
Investigational Site Number 840020, Rolling Hills Estates
Investigational Site Number 840045, Long Beach
Investigational Site Number 840041, North Hollywood
Investigational Site Number 484011, Veracruz
Investigational Site Number 840052, Costa Mesa
Investigational Site Number 840125, Newport Beach
Investigational Site Number 840019, Mission Viejo
Investigational Site Number 840109, Bakersfield
Investigational Site Number 840116, Fresno
Investigational Site Number 840036, Redwood City
Investigational Site Number 840021, San Jose
Investigational Site Number 380005, Catania
Investigational Site Number 840074, Roseville
Investigational Site Number 840040, Clackamas
Investigational Site Number 840001, Portland
Investigational Site Number 840039, Medford
Investigational Site Number 840051, Bellevue
Investigational Site Number 840043, Spokane
Investigational Site Number 643006, Moscow
Investigational Site Number 643003, Moscow
Investigational Site Number 170006, Bogotá
Investigational Site Number 170001, Bogotá
Investigational Site Number 170002, Bogotá
Investigational Site Number 170003, Bogotá
Investigational Site Number 643005, Moscow
Investigational Site Number 643002, Moscow
Investigational Site Number 643004, Moscow
Investigational Site Number 643001, Moscow
Investigational Site Number 643012, Yaroslavl
Investigational Site Number 643007, Saint Petersburg
Investigational Site Number 643008, Saint Petersburg
Investigational Site Number 643009, Saint Petersburg
Investigational Site Number 643010, Saint Petersburg
Investigational Site Number 643011, Ryazan
Investigational Site Number 152013, Talcahuano
Investigational Site Number 643013, Yekaterinburg
Investigational Site Number 152003, Quillota
Investigational Site Number 152011, Viña del Mar
Investigational Site Number 152004, Talca
Investigational Site Number 152016, Temuco
Investigational Site Number 152014, Santiago
Investigational Site Number 152001, Santiago
Investigational Site Number 152002, Santiago
Investigational Site Number 152008, Santiago
Investigational Site Number 152017, Santiago
Investigational Site Number 152007, Santiago
Investigational Site Number 152005, Santiago
Investigational Site Number 152009, Santiago
Investigational Site Number 840102, New Haven
Investigational Site Number 840064, Bangor
Investigational Site Number 840014, North Dartmouth
Investigational Site Number 840111, Brick
Investigational Site Number 840068, Ocean City
Investigational Site Number 840016, Princeton
Investigational Site Number 840096, Toms River
Investigational Site Number 840029, Lincoln
Investigational Site Number 840057, South Burlington
Investigational Site Number 032006, Bahía Blanca
Investigational Site Number 032002, Buenos Aires
Investigational Site Number 032007, Caba
Investigational Site Number 032001, Caba
Investigational Site Number 032003, Caba
Investigational Site Number 032010, Caba
Investigational Site Number 032005, Capital Federal
Investigational Site Number 032008, La Plata
Investigational Site Number 032004, Rosario
Investigational Site Number 032012, San Miguel de Tucumán
Investigational Site Number 032009, San Miguel de Tucumán
Investigational Site Number 076009, Florianópolis
Investigational Site Number 076007, Porto Alegre
Investigational Site Number 076001, Porto Alegre
Investigational Site Number 076003, Salvador
Investigational Site Number 076013, São Bernardo do Campo
Investigational Site Number 076012, São Paulo
Investigational Site Number 076008, São Paulo
Investigational Site Number 076006, São Paulo
Investigational Site Number 076002, Sorocaba
Investigational Site Number 124019, Burlington
Investigational Site Number 124009, Calgary
Investigational Site Number 124003, Mississauga
Investigational Site Number 124001, Montreal
Investigational Site Number 124012, Montreal
Investigational Site Number 124010, Montreal
Investigational Site Number 124013, Ottawa
Investigational Site Number 124018, Québec
Investigational Site Number 124014, Québec
Investigational Site Number 124008, Sherbrooke
Investigational Site Number 124015, Toronto
Investigational Site Number 124002, Toronto
Investigational Site Number 124007, Trois-Rivières
Investigational Site Number 124006, Vancouver
Investigational Site Number 152010, Valdivia
Investigational Site Number 152012, Viña del Mar
Investigational Site Number 392185, Akashi-Shi
Investigational Site Number 392128, Asahikawa-Shi
Investigational Site Number 392118, Chiyoda-Ku
Investigational Site Number 392112, Chūōku
Investigational Site Number 392157, Fukui-shi
Investigational Site Number 392137, Fukuoka
Investigational Site Number 392117, Fukuyama-Shi
Investigational Site Number 392121, Habikino-Shi
Investigational Site Number 392154, Higashiosaka-Shi
Investigational Site Number 392109, Himeji-Shi
Investigational Site Number 392108, Hiroshima
Investigational Site Number 392158, Hiroshima
Investigational Site Number 392107, Iizuka-Shi
Investigational Site Number 392101, Isesaki-Shi
Investigational Site Number 392147, Itabashi-Ku
Investigational Site Number 392150, Kagoshima
Investigational Site Number 392178, Kagoshima
Investigational Site Number 392110, Kanazawa
Investigational Site Number 392136, Kanazawa
Investigational Site Number 392142, Kasuga-Shi
Investigational Site Number 392166, Kawaguchi-Shi
Investigational Site Number 392119, Kishiwada-Shi
Investigational Site Number 392162, Kobe
Investigational Site Number 392182, Kodaira-Shi
Investigational Site Number 392174, Kokubunji-Shi
Investigational Site Number 392131, Koshi-Shi
Investigational Site Number 392183, Koshigaya-Shi
Investigational Site Number 392129, Kurashiki-Shi
Investigational Site Number 392153, Kyoto
Investigational Site Number 392176, Kyoto
Investigational Site Number 392184, Kyoto
Investigational Site Number 392133, Machida-Shi
Investigational Site Number 392135, Matsuyama
Investigational Site Number 392172, Mibu
Investigational Site Number 392114, Minatoku
Investigational Site Number 392122, Minatoku
Investigational Site Number 392144, Minatoku
Investigational Site Number 392106, Mizunami-Shi
Investigational Site Number 392164, Muroran-Shi
Investigational Site Number 392161, Nagakute-Shi
Investigational Site Number 392163, Nagoya
Investigational Site Number 392102, Naka-Gun
Investigational Site Number 392125, Nakano
Investigational Site Number 392115, Naruto-Shi
Investigational Site Number 392187, Obihiro-Shi
Investigational Site Number 392177, Ome-Shi
Investigational Site Number 392152, Osaka Sayama-Shi
Investigational Site Number 392155, Osaka Sayama-Shi
Investigational Site Number 392170, Osaki-Shi
Investigational Site Number 392138, Ota-Shi
Investigational Site Number 392123, Oura-Gun
Investigational Site Number 392120, Ōta-ku
Investigational Site Number 392127, Ōta-ku
Investigational Site Number 392169, Sagamihara-Shi
Investigational Site Number 392149, Sapporo
Investigational Site Number 392179, Seto-Shi
Investigational Site Number 392186, Shibuya-Ku
Investigational Site Number 392139, Shinagawa-Ku
Investigational Site Number 392167, Shinagawa-Ku
Investigational Site Number 392130, Shinjuku-Ku
Investigational Site Number 392165, Sumida-Ku
Investigational Site Number 392146, Tachikawa-Shi
Investigational Site Number 392173, Tachikawa-Shi
Investigational Site Number 392103, Tokyo
Investigational Site Number 392113, Tomakomai-Shi
Investigational Site Number 392151, Tsu
Investigational Site Number 392168, Uozu-Shi
Investigational Site Number 392132, Urasoe-Shi
Investigational Site Number 392134, Uruma
Investigational Site Number 392116, Wakayama
Investigational Site Number 392140, Yokohama
Investigational Site Number 392159, Yonago-Shi
Investigational Site Number 484010, México
Investigational Site Number 616006, Bialystok
Investigational Site Number 616003, Gdansk
Investigational Site Number 616007, Krakow
Investigational Site Number 616001, Lodz
Investigational Site Number 616005, Lodz
Investigational Site Number 616009, Lodz
Investigational Site Number 616002, Poznan
Investigational Site Number 616004, Sopot
Investigational Site Number 616008, Strzelce Opolskie
Investigational Site Number 710007, Pretoria
Investigational Site Number 410008, Seoul
Investigational Site Number 410006, Seoul
Investigational Site Number 410004, Seoul
Investigational Site Number 410012, Seoul
Investigational Site Number 410005, Seoul
Investigational Site Number 410007, Seoul
Investigational Site Number 410009, Seoul
Investigational Site Number 410010, Seoul
Investigational Site Number 410011, Seoul
Investigational Site Number 724002, Barcelona
Investigational Site Number 724001, Barcelona
Investigational Site Number 724010, Palma de Mallorca
Investigational Site Number 724004, Sant Boi de Llobregat
Investigational Site Number 792004, Ankara
Investigational Site Number 792008, Ankara
Investigational Site Number 804003, Kyiv
Investigational Site Number 804008, Kyiv
Investigational Site Number 804011, Kyiv
Investigational Site Number 804013, Kyiv
Investigational Site Number 804017, Kyiv
Investigational Site Number 804016, Kyiv
Investigational Site Number 826001, Bradford
Investigational Site Number 826002, London
Investigational Site Number 826005, Newcastle upon Tyne
Investigational Site Number 826007, Portsmouth
Investigational Site Number 826006, South Shields
Investigational Site Number 826003, Sutton in Ashfield
Lead Sponsor
Regeneron Pharmaceuticals
INDUSTRY
Sanofi
INDUSTRY