Evaluation of Dupilumab in Patients With Persistent Asthma (Liberty Asthma Quest)

PHASE3CompletedINTERVENTIONAL
Enrollment

1,902

Participants

Timeline

Start Date

April 27, 2015

Primary Completion Date

July 29, 2017

Study Completion Date

November 23, 2017

Conditions
Asthma
Interventions
DRUG

Dupilumab

Solution for injection, Subcutaneous injection in the abdomen, upper thigh or upper arm.

DRUG

Placebo

Solution for injection, Subcutaneous injection in the abdomen, upper thigh or upper arm.

DRUG

Inhaled corticosteroid (ICS) therapy

Oral inhalation, stable dose (medium or high dose) of ICS in combination with up to 2 other controller medicines (second or third controller therapy)

DRUG

Albuterol/Salbutamol

Oral inhalation as needed

DRUG

Levalbuterol/Levosalbutamol

Oral inhalation as needed

Trial Locations (389)

41

Investigational Site Number 152015, Concepción

333

Investigational Site Number 158006, Taoyuan District

807

Investigational Site Number 158004, Kaohsiung City

1120

Investigational Site Number 032011, Caba

2100

Investigational Site Number 348003, Gödöllö

2560

Investigational Site Number 036005, Campbelltown

3050

Investigational Site Number 036004, Parkville

3168

Investigational Site Number 036001, Clayton

3199

Investigational Site Number 036002, Frankston

4001

Investigational Site Number 710005, Durban

4071

Investigational Site Number 710006, Durban

5064

Investigational Site Number 036006, Glen Osmond

6150

Investigational Site Number 036003, Murdoch

7505

Investigational Site Number 710011, Cape Town

7530

Investigational Site Number 710004, Cape Town

7700

Investigational Site Number 710001, Cape Town

Investigational Site Number 710002, Cape Town

7764

Investigational Site Number 710010, Cape Town

8000

Investigational Site Number 710003, Cape Town

9400

Investigational Site Number 710009, Winnie Mandela

10029

Investigational Site Number 840065, New York

10043

Investigational Site Number 158001, Taipei

10128

Investigational Site Number 380011, Torino

10457

Investigational Site Number 840031, The Bronx

10787

Investigational Site Number 276006, Berlin

11031

Investigational Site Number 158009, Taipei

11435

Investigational Site Number 840106, Jamaica

11765

Investigational Site Number 410014, Uijeongbu-si

13015

Investigational Site Number 250010, Marseille

14584

Investigational Site Number 410002, Bucheon-si

14642

Investigational Site Number 840076, Rochester

15213

Investigational Site Number 840028, Pittsburgh

15241

Investigational Site Number 840091, Pittsburgh

15562

Investigational Site Number 276005, Rüdersdorf

15706

Investigational Site Number 724006, Santiago de Compostela

16059

Investigational Site Number 792003, Bursa

16499

Investigational Site Number 410001, Suwon

17033

Investigational Site Number 840085, Hershey

19102

Investigational Site Number 840081, Philadelphia

19107

Investigational Site Number 840010, Philadelphia

19140

Investigational Site Number 840067, Philadelphia

20815

Investigational Site Number 840017, Chevy Chase

20878

Investigational Site Number 840073, Gaithersburg

21001

Investigational Site Number 804012, Vinnytsia

21162

Investigational Site Number 840127, White Marsh

21237

Investigational Site Number 840080, Baltimore

21565

Investigational Site Number 410013, Incheon

22030

Investigational Site Number 840059, Fairfax

23294

Investigational Site Number 840113, Richmond

23538

Investigational Site Number 276007, Lübeck

23561

Investigational Site Number 158008, New Taipei City

27103

Investigational Site Number 840003, Papillion

27262

Investigational Site Number 840007, High Point

27403

Investigational Site Number 840107, Greensboro

27705

Investigational Site Number 840108, Durham

28223

Investigational Site Number 724005, Pozuelo de Alarcón

28226

Investigational Site Number 840126, Charlotte

28277

Investigational Site Number 840083, Charlotte

28644

Investigational Site Number 410003, Cheongju-si

29303

Investigational Site Number 840054, Spartanburg

29407

Investigational Site Number 840082, Charleston

29607

Investigational Site Number 840117, Greenville

29609

Investigational Site Number 250002, Brest

29651

Investigational Site Number 840100, Greer

30506

Investigational Site Number 840084, Gainesville

30625

Investigational Site Number 276004, Hanover

31020

Investigational Site Number 484013, Chihuahua City

31200

Investigational Site Number 484006, Chihuahua City

31406

Investigational Site Number 840044, Savannah

33012

Investigational Site Number 840122, Hialeah

33070

Investigational Site Number 792002, Mersin

33143

Investigational Site Number 840114, South Miami

33173

Investigational Site Number 840069, Miami

33180

Investigational Site Number 840037, Aventura

33470

Investigational Site Number 840053, Loxahatchee Groves

33472

Investigational Site Number 840018, Boynton Beach

33511

Investigational Site Number 840105, Brandon

33612

Investigational Site Number 840048, Tampa

33765

Investigational Site Number 840092, Clearwater

34080

Investigational Site Number 484008, Durango

34098

Investigational Site Number 792001, Istanbul

34239

Investigational Site Number 840055, Sarasota

34295

Investigational Site Number 250005, Montpellier

34471

Investigational Site Number 840123, Ocala

34474

Investigational Site Number 840071, Ocala

34668

Investigational Site Number 792007, Istanbul

34761

Investigational Site Number 840115, Ocoee

35040

Investigational Site Number 792005, Izmir

35110

Investigational Site Number 792010, Izmir

35209

Investigational Site Number 840047, Birmingham

36038

Investigational Site Number 804002, Poltava

40201

Investigational Site Number 158005, Taichung

40447

Investigational Site Number 158007, Taichung

41017

Investigational Site Number 840032, Fort Mitchell

41071

Investigational Site Number 724008, Seville

41100

Investigational Site Number 792011, Kocaeli

41124

Investigational Site Number 380002, Modena

42123

Investigational Site Number 380014, Reggio Emilia

42303

Investigational Site Number 840009, Owensboro

43617

Investigational Site Number 840042, Toledo

44093

Investigational Site Number 250003, Nantes

44100

Investigational Site Number 484001, Guadalajara

44124

Investigational Site Number 380003, Ferrara

44130

Investigational Site Number 840049, Middleburg Heights

44789

Investigational Site Number 276003, Bochum

45100

Investigational Site Number 484015, Zapopan

45241

Investigational Site Number 840046, Cincinnati

46000

Investigational Site Number 804014, Ternopil

46017

Investigational Site Number 724007, Valencia

49101

Investigational Site Number 804023, Dnipro

49201

Investigational Site Number 410015, Busan

50134

Investigational Site Number 380006, Florence

52242

Investigational Site Number 840089, Iowa City

53100

Investigational Site Number 792006, Rize

54511

Investigational Site Number 250014, Vandœuvre-lès-Nancy

54769

Investigational Site Number 484014, Cuautitlán Izcalli

55131

Investigational Site Number 276001, Mainz

55402

Investigational Site Number 840005, Minneapolis

56068

Investigational Site Number 276009, Koblenz

56124

Investigational Site Number 380001, Pisa

58001

Investigational Site Number 804007, Chernivtsi

59000

Investigational Site Number 250013, Lille

59037

Investigational Site Number 250011, Lille

59808

Investigational Site Number 840026, Missoula

60126

Investigational Site Number 380004, Ancona

60305

Investigational Site Number 840015, River Forest

60596

Investigational Site Number 276010, Frankfurt am Main

60611

Investigational Site Number 840101, Chicago

61058

Investigational Site Number 804005, Kharkiv

61093

Investigational Site Number 804021, Kharkiv

61124

Investigational Site Number 804001, Kharkiv

63141

Investigational Site Number 840002, St Louis

Investigational Site Number 840093, St Louis

64111

Investigational Site Number 840013, Kansas City

64460

Investigational Site Number 484003, Monterrey

64718

Investigational Site Number 484004, Mexico City

65025

Investigational Site Number 804006, Odesa

66465

Investigational Site Number 484007, Monterrey

67091

Investigational Site Number 250008, Strasbourg

68131

Investigational Site Number 840078, Omaha

69076

Investigational Site Number 804022, Zaporizhia

69317

Investigational Site Number 250004, Lyon

71122

Investigational Site Number 380010, Foggia

71450

Investigational Site Number 792009, Kırıkkale

72209

Investigational Site Number 840132, Little Rock

73034

Investigational Site Number 840112, Edmond

73103

Investigational Site Number 840121, Oklahoma City

74136

Investigational Site Number 840104, Tulsa

75012

Investigational Site Number 250012, Paris

75018

Investigational Site Number 250001, Paris

75069

Investigational Site Number 840070, McKinney

75071

Investigational Site Number 840128, McKinney

75093

Investigational Site Number 840118, Plano

75231

Investigational Site Number 840008, Dallas

75246

Investigational Site Number 840094, Dallas

76018

Investigational Site Number 804004, Ivano-Frankivsk

Investigational Site Number 804009, Ivano-Frankivsk

76109

Investigational Site Number 840022, Fort Worth

76244

Investigational Site Number 840027, Fort Worth

76542

Investigational Site Number 840066, Killeen

76800

Investigational Site Number 484012, San Juan del Río

77380

Investigational Site Number 840119, Spring

77429

Investigational Site Number 840124, Cypress

77474

Investigational Site Number 840133, Sealy

78006

Investigational Site Number 840038, Boerne

78229

Investigational Site Number 840012, San Antonio

78233

Investigational Site Number 840050, Live Oak

78251

Investigational Site Number 840129, San Antonio

78759

Investigational Site Number 840098, Austin

79106

Investigational Site Number 840062, Amarillo

79903

Investigational Site Number 840023, El Paso

80112

Investigational Site Number 840004, Centennial

80230

Investigational Site Number 840034, Denver

80246

Investigational Site Number 840130, Denver

80907

Investigational Site Number 840025, Colorado Springs

82445

Investigational Site Number 158002, Kaohsiung City

83301

Investigational Site Number 840079, Twin Falls

84020

Investigational Site Number 840035, Draper

84107

Investigational Site Number 840077, Murray

85234

Investigational Site Number 840099, Gilbert

85251

Investigational Site Number 840087, Scottsdale

86001

Investigational Site Number 840056, Flagstaff

90025

Investigational Site Number 840011, Los Angeles

90048

Investigational Site Number 840061, Los Angeles

90064

Investigational Site Number 840097, Los Angeles

90146

Investigational Site Number 380009, Palermo

90274

Investigational Site Number 840020, Rolling Hills Estates

90720

Investigational Site Number 840045, Long Beach

91606

Investigational Site Number 840041, North Hollywood

91910

Investigational Site Number 484011, Veracruz

92626

Investigational Site Number 840052, Costa Mesa

92663

Investigational Site Number 840125, Newport Beach

92691

Investigational Site Number 840019, Mission Viejo

93301

Investigational Site Number 840109, Bakersfield

93720

Investigational Site Number 840116, Fresno

94063

Investigational Site Number 840036, Redwood City

95117

Investigational Site Number 840021, San Jose

95123

Investigational Site Number 380005, Catania

95661

Investigational Site Number 840074, Roseville

97015

Investigational Site Number 840040, Clackamas

97223

Investigational Site Number 840001, Portland

97504

Investigational Site Number 840039, Medford

98225

Investigational Site Number 840051, Bellevue

99202

Investigational Site Number 840043, Spokane

105077

Investigational Site Number 643006, Moscow

109240

Investigational Site Number 643003, Moscow

110131

Investigational Site Number 170006, Bogotá

110221

Investigational Site Number 170001, Bogotá

110231

Investigational Site Number 170002, Bogotá

111321

Investigational Site Number 170003, Bogotá

115280

Investigational Site Number 643005, Moscow

117574

Investigational Site Number 643002, Moscow

123182

Investigational Site Number 643004, Moscow

125315

Investigational Site Number 643001, Moscow

150003

Investigational Site Number 643012, Yaroslavl

193231

Investigational Site Number 643007, Saint Petersburg

194354

Investigational Site Number 643008, Saint Petersburg

195030

Investigational Site Number 643009, Saint Petersburg

197022

Investigational Site Number 643010, Saint Petersburg

390039

Investigational Site Number 643011, Ryazan

427918

Investigational Site Number 152013, Talcahuano

620109

Investigational Site Number 643013, Yekaterinburg

2260877

Investigational Site Number 152003, Quillota

2520594

Investigational Site Number 152011, Viña del Mar

3460001

Investigational Site Number 152004, Talca

4781156

Investigational Site Number 152016, Temuco

7500588

Investigational Site Number 152014, Santiago

7500692

Investigational Site Number 152001, Santiago

7500698

Investigational Site Number 152002, Santiago

7500710

Investigational Site Number 152008, Santiago

7560994

Investigational Site Number 152017, Santiago

8207257

Investigational Site Number 152007, Santiago

8380456

Investigational Site Number 152005, Santiago

8910131

Investigational Site Number 152009, Santiago

06504

Investigational Site Number 840102, New Haven

04401

Investigational Site Number 840064, Bangor

02747

Investigational Site Number 840014, North Dartmouth

08723

Investigational Site Number 840111, Brick

07712

Investigational Site Number 840068, Ocean City

08540

Investigational Site Number 840016, Princeton

08775

Investigational Site Number 840096, Toms River

02286

Investigational Site Number 840029, Lincoln

05403

Investigational Site Number 840057, South Burlington

B8000JRB

Investigational Site Number 032006, Bahía Blanca

C1121ABE

Investigational Site Number 032002, Buenos Aires

C1414AIF

Investigational Site Number 032007, Caba

C1425BEN

Investigational Site Number 032001, Caba

C1425FVH

Investigational Site Number 032003, Caba

C1426ABP

Investigational Site Number 032010, Caba

C1425DUC

Investigational Site Number 032005, Capital Federal

B1900DXM

Investigational Site Number 032008, La Plata

S2000JKR

Investigational Site Number 032004, Rosario

T4000CHE

Investigational Site Number 032012, San Miguel de Tucumán

T4000IAR

Investigational Site Number 032009, San Miguel de Tucumán

88040-970

Investigational Site Number 076009, Florianópolis

90020-090

Investigational Site Number 076007, Porto Alegre

90610-000

Investigational Site Number 076001, Porto Alegre

41940-455

Investigational Site Number 076003, Salvador

09715-090

Investigational Site Number 076013, São Bernardo do Campo

04266-010

Investigational Site Number 076012, São Paulo

05403-000

Investigational Site Number 076008, São Paulo

05437-010

Investigational Site Number 076006, São Paulo

18040-425

Investigational Site Number 076002, Sorocaba

L7N 3V2

Investigational Site Number 124019, Burlington

T2N 4Z6

Investigational Site Number 124009, Calgary

L5A 3V4

Investigational Site Number 124003, Mississauga

H2W 1T8

Investigational Site Number 124001, Montreal

H4A 3J1

Investigational Site Number 124012, Montreal

H4J 1C5

Investigational Site Number 124010, Montreal

K1G 6C6

Investigational Site Number 124013, Ottawa

G1V 4G5

Investigational Site Number 124018, Québec

G1V 4W2

Investigational Site Number 124014, Québec

J1H 5N4

Investigational Site Number 124008, Sherbrooke

M5G 1E2

Investigational Site Number 124015, Toronto

M5T 3A9

Investigational Site Number 124002, Toronto

G8T 7A1

Investigational Site Number 124007, Trois-Rivières

V5Z 1M9

Investigational Site Number 124006, Vancouver

Unknown

Investigational Site Number 152010, Valdivia

Investigational Site Number 152012, Viña del Mar

Investigational Site Number 392185, Akashi-Shi

Investigational Site Number 392128, Asahikawa-Shi

Investigational Site Number 392118, Chiyoda-Ku

Investigational Site Number 392112, Chūōku

Investigational Site Number 392157, Fukui-shi

Investigational Site Number 392137, Fukuoka

Investigational Site Number 392117, Fukuyama-Shi

Investigational Site Number 392121, Habikino-Shi

Investigational Site Number 392154, Higashiosaka-Shi

Investigational Site Number 392109, Himeji-Shi

Investigational Site Number 392108, Hiroshima

Investigational Site Number 392158, Hiroshima

Investigational Site Number 392107, Iizuka-Shi

Investigational Site Number 392101, Isesaki-Shi

Investigational Site Number 392147, Itabashi-Ku

Investigational Site Number 392150, Kagoshima

Investigational Site Number 392178, Kagoshima

Investigational Site Number 392110, Kanazawa

Investigational Site Number 392136, Kanazawa

Investigational Site Number 392142, Kasuga-Shi

Investigational Site Number 392166, Kawaguchi-Shi

Investigational Site Number 392119, Kishiwada-Shi

Investigational Site Number 392162, Kobe

Investigational Site Number 392182, Kodaira-Shi

Investigational Site Number 392174, Kokubunji-Shi

Investigational Site Number 392131, Koshi-Shi

Investigational Site Number 392183, Koshigaya-Shi

Investigational Site Number 392129, Kurashiki-Shi

Investigational Site Number 392153, Kyoto

Investigational Site Number 392176, Kyoto

Investigational Site Number 392184, Kyoto

Investigational Site Number 392133, Machida-Shi

Investigational Site Number 392135, Matsuyama

Investigational Site Number 392172, Mibu

Investigational Site Number 392114, Minatoku

Investigational Site Number 392122, Minatoku

Investigational Site Number 392144, Minatoku

Investigational Site Number 392106, Mizunami-Shi

Investigational Site Number 392164, Muroran-Shi

Investigational Site Number 392161, Nagakute-Shi

Investigational Site Number 392163, Nagoya

Investigational Site Number 392102, Naka-Gun

Investigational Site Number 392125, Nakano

Investigational Site Number 392115, Naruto-Shi

Investigational Site Number 392187, Obihiro-Shi

Investigational Site Number 392177, Ome-Shi

Investigational Site Number 392152, Osaka Sayama-Shi

Investigational Site Number 392155, Osaka Sayama-Shi

Investigational Site Number 392170, Osaki-Shi

Investigational Site Number 392138, Ota-Shi

Investigational Site Number 392123, Oura-Gun

Investigational Site Number 392120, Ōta-ku

Investigational Site Number 392127, Ōta-ku

Investigational Site Number 392169, Sagamihara-Shi

Investigational Site Number 392149, Sapporo

Investigational Site Number 392179, Seto-Shi

Investigational Site Number 392186, Shibuya-Ku

Investigational Site Number 392139, Shinagawa-Ku

Investigational Site Number 392167, Shinagawa-Ku

Investigational Site Number 392130, Shinjuku-Ku

Investigational Site Number 392165, Sumida-Ku

Investigational Site Number 392146, Tachikawa-Shi

Investigational Site Number 392173, Tachikawa-Shi

Investigational Site Number 392103, Tokyo

Investigational Site Number 392113, Tomakomai-Shi

Investigational Site Number 392151, Tsu

Investigational Site Number 392168, Uozu-Shi

Investigational Site Number 392132, Urasoe-Shi

Investigational Site Number 392134, Uruma

Investigational Site Number 392116, Wakayama

Investigational Site Number 392140, Yokohama

Investigational Site Number 392159, Yonago-Shi

06700

Investigational Site Number 484010, México

15-010

Investigational Site Number 616006, Bialystok

80-952

Investigational Site Number 616003, Gdansk

31-159

Investigational Site Number 616007, Krakow

90-141

Investigational Site Number 616001, Lodz

90-153

Investigational Site Number 616005, Lodz

90-329

Investigational Site Number 616009, Lodz

60-693

Investigational Site Number 616002, Poznan

81-741

Investigational Site Number 616004, Sopot

47-100

Investigational Site Number 616008, Strzelce Opolskie

0087

Investigational Site Number 710007, Pretoria

02559

Investigational Site Number 410008, Seoul

03080

Investigational Site Number 410006, Seoul

03722

Investigational Site Number 410004, Seoul

04763

Investigational Site Number 410012, Seoul

05505

Investigational Site Number 410005, Seoul

06351

Investigational Site Number 410007, Seoul

06591

Investigational Site Number 410009, Seoul

06973

Investigational Site Number 410010, Seoul

08308

Investigational Site Number 410011, Seoul

08035

Investigational Site Number 724002, Barcelona

08036

Investigational Site Number 724001, Barcelona

07120

Investigational Site Number 724010, Palma de Mallorca

08830

Investigational Site Number 724004, Sant Boi de Llobregat

06100

Investigational Site Number 792004, Ankara

Investigational Site Number 792008, Ankara

03680

Investigational Site Number 804003, Kyiv

Investigational Site Number 804008, Kyiv

Investigational Site Number 804011, Kyiv

Investigational Site Number 804013, Kyiv

Investigational Site Number 804017, Kyiv

04050

Investigational Site Number 804016, Kyiv

BD9 6RJ

Investigational Site Number 826001, Bradford

EC1M 6BQ

Investigational Site Number 826002, London

NE7 7DN

Investigational Site Number 826005, Newcastle upon Tyne

PO6 3LY

Investigational Site Number 826007, Portsmouth

NE34 0PL

Investigational Site Number 826006, South Shields

NG17 4JL

Investigational Site Number 826003, Sutton in Ashfield

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Regeneron Pharmaceuticals

INDUSTRY

lead

Sanofi

INDUSTRY