572
Participants
Start Date
July 20, 2015
Primary Completion Date
February 4, 2020
Study Completion Date
March 8, 2022
Atezolizumab (MPDL3280A) [TECENTRIQ], an engineered anti-PDL1 antibody
Atezolizumab 1200 milligram (mg) will be administered as intravenous infusion every 21 days until loss of clinical benefit (as assessed by the investigator), unacceptable toxicity, or death (maximum up to approximately 58 months).
Carboplatin
Carboplatin will be administered as intravenous infusion at a dose of area under the concentration-time curve (AUC) 6 when given in combination with pemetrexed or at a dose of AUC 5 when given in combination with gemcitabine, every 21 days for 4 or 6 cycles as per local standard of care.
Cisplatin
Cisplatin will be administered as intravenous infusion at a dose of 75 mg per meter squared (mg/m\^2) every 21 days for 4 or 6 cycles as per local standard of care.
Gemcitabine
Gemcitabine will be administered as intravenous infusion at a dose of 1250 mg/m\^2 (in combination with cisplatin) or 1000 mg/m\^2 (in combination with carboplatin), on Days 1 and 8 of each 21-day cycle for 4 or 6 cycles as per local standard of care.
Pemetrexed
Pemetrexed will be administered as intravenous infusion at a dose of 500 mg/m\^2 on Day 1 of each 21-day cycle as per local standard of care until disease progression (per RECIST v1.1), unacceptable toxicity, or death (maximum up to approximately 58 months).
Uzsoki Utcai Korhaz, Budapest
Cukurova University Medical Faculty Balcali Hospital, Adana
Szabolcs-Szatmar-Bereg Megyei; Korhazak es Egyetemi Oktatokorhaz, Nyíregyháza
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet; Megyei Onkologiai Kozpont, Szolnok
Pecsi Tudomanyegyetem, Pécs
Azienda Ospedaliera Città della Salute e della Scienza di Torino, Turin
Clinical Center of Serbia, Belgrade
Institute for Oncology and Radiology of Serbia; Medical Oncology, Belgrade
Sotiria Chest Hospital of Athens, Athens
Consorcio Hospitalario Provincial de Castellon, Castellon de LA Plana/castello de LA Plana
Seoul National University Bundang Hospital, Seongnam-si
Hospital Universitario A Coruña, A Coruña
Azienda Socio Sanitaria Territoriale ? ASST di Monza, Monza
Istituto Nazionale dei Tumori, Monza
Istituto Clinico Humanitas, Rozzano (MI)
Ospedale San Raffaele S.r.l., Milan
Istituto Europeo Di Oncologia, Milan
Communal Nonprofit Enterprise Podilsky Regional Center Of Oncology OfTheVinnytsia Regional Council, Vinnytsia
University of Maryland Greenebaum Cancer Center, Baltimore
Institute of Lung Diseases Vojvodina, Kamenitz
Hematology Oncology Associates of Fredericksburg, Inc., Fredericksburg
Complejo Hospitalario de Jaen, Jaén
Asst Papa Giovanni XXIII, Bergamo
Private Enterprise Private Manufacturing Company Acinus, Kirovograd
Azienda Ospedaliera Istituti Ospitalieri, Cremona
Pius-Hospital Oldenburg, Oldenburg
Hospital Clinico San Carlos; Servicio de Oncologia, Madrid
Centro Di Riferimento Oncologico; Struttura Operativa Complessa Di Oncologia Medica B, Aviano
Lynn Cancer Institute - West, Boca Raton
Clinical Center Kragujevac, Kragujevac
Istanbul University Cerrahpasa Medical Faculty, Istanbul
Clinique Clémentville, Montpellier
Ege Universitesi Tip Fakultesi Hastanesi, Izmir
Izmir Dr. Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi, Izmir
Azienda Ospedaliera Universitaria Integrata Verona; UOC Oncologia, Verona
Vanderbilt University Medical Center; Multiple Sclerosis Center, Nashville
Sarah Cannon Cancer Center, Germantown
Khon Kaen University, Khon Kaen
Municipal non profit enterprise of Sumy Regional Council Sumy Regional Clinical Oncology Disp, Sumy
Hospital Universitario Virgen Macarena, Seville
The Municipal Enterprise Volyn Regional Medical Oncology Centre of the Volyn Regional Council, Lutsk
Inonu University Faculty of Medicine Turgut Ozal Medical Center, Malatya
Hospital Clinico Universitario de Valencia, Valencia
Hospital Universitari i Politecnic La Fe de Valencia, Valencia
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola
Hospital Universitario Cruces, Barakaldo
Communal Non-profit Enterprise City Clinical Hospital #4 of Dnipro City Council - PPDS; Chemotherapy, Dnipro
CHU Angers, Angers
Hosp Clinico Univ Lozano Blesa; División De Oncología Médica, Zaragoza
Hospital Universitario Miguel Servet, Zaragoza
Centre D'oncologie de Gentilly, Nancy
EUROMEDICA General Clinic of Thessaloniki; Gastroenterology Department, Thessaloniki
Chiang Rai Prachanukroh Hospital, Muang
Thermi Clinic, Thermi, Thessaloniki
Georgios Papanikolaou General Hosp. of Thessaloniki, Thessaloniki
Chonnam National University Hwasun Hospital, Jeollanam-do
Municipal Noncommercial Institution Regional Center of Oncology, Kharkiv
Buddhachinnaraj Hospital, Phitsanulok
Municipal Noncomercial Enterprise Odessa Regional Oncology Center ofthe Odessa StateAdministration, Odesa
Centre Paul Strauss, Strasbourg
Hopital Tenon, Paris
Asklepios-Fachklinik Muenchen-Gauting; Klinik Für Pneumologie, Gauting
Hôpital Universitaire Dupuytren, Limoges
Prince of Songkla University; Department Of Internal Medicine, Faculty Of Medicine, Hat Yai
University of California San Diego, La Jolla
Hospital d Instructions des Armees Percy, Clamart
Hopital d'Instruction des Armees de Begin, Saint-Mandé
Azienda Ospedaliero-Universitaria ?PoliclinicoVittorio Emanuele?- P.O. G. Rodolico; Oncologia Medica, Catania
Oregon Health & Science Uni, Portland
Centre Hospitalier Regional La Reunion Site Felix Guyon, Saint-Denis
Centre Hospitalier Regional Sud Reunion, Saint-Pierre
VA Puget Sound Health Care Sys, Seattle
Principal Military Clinical Hospital n.a. N.N. Burdenko, Moscow
Moscow City Oncology Hospital #62, Moscovskaya Oblast
Harbin Medical University Tumor Hospital, Harbin
Arkhangelsk Regional Clinical Oncology Dispensary, Arkhangelsk
Saint Petersburg Clinical Hospital of the Russian Academy of Sciences, Saint Petersburg
Leningrad Regional Clinical Hospital, Saint Petersburg
St. Petersburg Med Univ; n.a. I.P. Pavlov; Pulmonology Research, Saint Petersburg
Oncology Center Sf. Nectarie, Craiova
Federal State Institution Medical Radiology Research Center, Obninsk
Oncocenter Clinical Oncology, Timi?oara
Oncomed SRL, Timișoara
Regional Clinical Oncology Center, Ryazan
Prof. Dr. I. Chiricuta Institute of Oncology, Cluj-Napoca
Volgograd Regional Clinical Oncology Dispensary, Volgograd
Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic, Kazan'
Mordovia State University, Saransk
Teo Health SA - Saint Constantin Hospital, Brasov
Sibiu Emergency Clinical County Hospital, Sibiu
Institutul Regional de Oncologie Iasi; Clinica de Hematologie, Iași
Yale Cancer Center, New Haven
Centro de Pesquisas Clinicas em Oncologia - CPCO, Cachoeiro de Itapemirim
Oncovida*X, Salvador
Instituto Nacional de Cancer - INCa; Oncologia, Rio de Janeiro
Associacao Hospital de Caridade Ijui*X; Departamento De Oncologia, Ijuí
Hospital da Cidade de Passo Fundo; Centro de Pesquisa em Oncologia, Passo Fundo
Santa Casa de Misericordia de Porto Alegre, Porto Alegre
Hospital Sao Lucas - PUCRS, Porto Alegre
Instituto Joinvilense de Hematologia E Oncologia, Joinville
*X*Fundacao PIO XII, Barretos
Instituto Do Câncer Do Estado de São Paulo Octávio Frias de Oliveira, São Paulo
Hospital Santa Marcelina, São Paulo
IASO General Hospital of Athens, Athens
Metropolitan Hospital, Athens
Attikon University General Hospital, Chaïdári
University General Hospital of Larissa, Larissa
University General Hospital of Patras, Pátrai
Bioclinic Thessaloniki, Thessaloniki
Papageorgiou General Hospital of Thessaloniki, Thessaloniki
Aichi Cancer Center Hospital; Respiratory Medicine, Aichi
Nagoya University Hospital; Respiratory Medicine, Aichi
Kyushu University Hospital; Respiratory, Fukuoka
Hokkaido University Hospital, Hokkaido
Kobe City Medical Center General Hospital; Respiratory Medicine, Hyōgo
Hyogo Cancer Center; Thoracic Oncology, Hyōgo
Ibaraki Prefectural Central Hospital; Division of respiratory, Ibaraki
Sendai Kousei Hospital; Pulmonary Medicine, Miyagi
Okayama University Hospital; Respiratory and Allergy Medicine, Okayama
Osaka International Cancer Institute; Thoracic Oncology, Osaka
Kansai Medical university Hospital; Thoracic Oncology, Osaka
Osaka Habikino Medical Center, Osaka
National Hospital Organization Kinki-Chuo Chest Medical Center, Sakaishi
Saitama Cancer Center; Thoracic Oncology, Satima
National Cancer Center Hospital; Thoracic Medical Oncology, Tokyo
Tokyo Medical University Hospital; Dept of Surgery, Tokyo
Uniwersyteckie Centrum Kliniczne, Gdansk
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie; Oddzial onkologii z pododdzialem chemioterapii, Olsztyn
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy, Otwock
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu, Poznan
Med-Polonia Sp. z o.o., Poznan
Kangbuk Samsung Hospital, Seoul
Hospital Universitario Son Espases, Palma de Mallorca
Hospital Son Llatzer, Palma de Mallorca
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Badalona
Hospital del Mar, Barcelona
Hospital Universitario Vall d'Hebron - PPDS, Barcelona
Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara
Kyiv Railway Clinical Hospital #3 of Branch Health Center of the PJSC Ukrainian Railway, Kyiv
Birmingham Heartlands Hospital, Birmingham
Colchester General Hospital, Colchester, Essex
Christie Hospital, Manchester
Hoffmann-La Roche
INDUSTRY