47
Participants
Start Date
April 30, 2015
Primary Completion Date
October 31, 2019
Study Completion Date
October 31, 2019
Regorafenib
The dose of regorafenib will be escalated in fixed increments to establish the maximum tolerated dose (MTD) from day 1-21 against a cytotoxic backbone of paclitaxel 80mg/m2 on days 1, 8 and 15 of a 28 day cycle
Paclitaxel
Paclitaxel will be administered in combination with regorafenib to serve as a cytotoxic backbone, it will be given in a dose of 80mg/m2 on days 1,8 and 15 of a 28 day cycle.
Academic Medical Center, Medical Oncology, Amsterdam
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
OTHER