Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine

PHASE4CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

August 31, 2015

Primary Completion Date

May 31, 2016

Study Completion Date

May 31, 2016

Conditions
Coronary Artery Disease
Interventions
DRUG

Methylnaltrexone

Methylnaltrexone will be administered diluted with 5 ml of normal saline as a single iv bolus

OTHER

Placebo

Placebo will be administered as a 0.9% sodium chloride iv injection

DRUG

Morphine

After methylnaltrexone, patients will receive 5-mg intravenous morphine

DRUG

Ticagrelor

After morphine administration, patients will receive a 180-mg ticagrelor loading dose

Trial Locations (1)

32209

University of Florida, Jacksonville

All Listed Sponsors
lead

University of Florida

OTHER

NCT02403830 - Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine | Biotech Hunter | Biotech Hunter