120
Participants
Start Date
May 1, 2015
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2025
Surgery followed by adjuvant second-line therapy
"Surgery:~Surgery must take place between day 1 and 14 after study inclusion and within 21 days from the MRI on which recurrence was diagnosed. The modalities of surgery and the choice of pre- and intra-operative technical adjuncts is at the treating neurosurgery discretion. Surgery must take place between day 1 and 14 after study inclusion and within 21 days from the MRI on which recurrence was diagnosed. The modalities of surgery and the choice of pre- and intra-operative technical adjuncts is at the treating neurosurgery discretion. However, some form of intra-operative resection control (iMRI or intra-operative fluorescence) and function control (electrophysiology) should be available to the surgeon and used when warranted.~Adjuvant second-line therapy:~Patients will be seen after surgery by the treating neurooncologist. Modalities of adjuvant second-line therapy are individually defined according to local guidelines and are not stipulated by study protocol."
Second-line therapy alone
Patients randomized to the non-surgical cohort receive second-line therapy according to local guidelines. Modalities thereof are not stipulated by study protocol.
RECRUITING
Dep. of Neurosurgery, Centre hospitalier universitaire vaudois, Lausanne
ACTIVE_NOT_RECRUITING
Dep. of Neurosurger, Hôpitaux Universitaires de Genève, Geneva
RECRUITING
Dep. of Neurosurgery, Bern University Hospital, Bern
RECRUITING
Universitätsspital Basel, Basel
RECRUITING
Kantonsspital Aarau, Aarau
RECRUITING
Kantonsspital Luzern, Lucerne
RECRUITING
Ospedale Regionale di Lugano, Lugano
RECRUITING
Dep. of Neurosurgery, University Hospital of Zurich, Zurich
RECRUITING
Department of Neurosurgery, Kantonsspital St. Gallen, Sankt Gallen
RECRUITING
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan
RECRUITING
Universitätsklinikum Gießen und Marburg, Giessen
RECRUITING
Universitätsklinikum Münster, Münster
RECRUITING
Department of Neurosurgery, Universitätsklinikum Frankfurt, Frankfurt
RECRUITING
Dep. of Neurosurgery, Universitätsklinikum Freiburg, Freiburg im Breisgau
RECRUITING
Helios Klinikum Erfurt, Erfurt
RECRUITING
Universitätsklinikum Innsbruck, Innsbruck
RECRUITING
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz
RECRUITING
Department of Neurosurgery, Amsterdam University Medical Center, Amsterdam
RECRUITING
Department of Neurosurgery, Radboud University Medical Center, Nijmegen, Nijmegen
RECRUITING
Department of Neurosurgery, Haaglanden Medical Center, The Hague, The Hague
RECRUITING
Department of Neurosurgery, L'Hospitalet de Llobregat, Barcelona, Barcelona
RECRUITING
Department of Neurosurgery, Puerta de Hierro University Hospital, Madrid, Madrid
RECRUITING
Department of Neurosurgery, Hospital of Larissa & General Hospital of Larissa, Larissa
RECRUITING
Department of Neurosurgery, AHEPA University Hospital, Thessaloniki
RECRUITING
Department of Neurosurgery, Centro Hospitalar Universitário Lisboa Norte - Hospital de Santa Maria, Lisbon
RECRUITING
"Department of Neurosurgery, Spitalul Clinic De Urgență Bagdasar-Arseni", Bucharest
European Organisation for Research and Treatment of Cancer - EORTC
NETWORK
Insel Gruppe AG, University Hospital Bern
OTHER