A Study of Treatment With RO6864018 in Virologically Suppressed Participants With Chronic Hepatitis B Virus (HBV) Infection

PHASE2CompletedINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

May 17, 2015

Primary Completion Date

October 16, 2017

Study Completion Date

October 16, 2017

Conditions
Hepatitis B, Chronic
Interventions
DRUG

Entecavir

Entecavir will be administered as per local labeling.

DRUG

Placebo

Participants will be administered PO placebo capsules matched to RO6864018, either QOD or QWk for 12 weeks of treatment.

DRUG

RO6864018

Participants will be administered RO6864018 as 200-mg PO capsules at a dose of 800 mg or 1200 mg, either QOD or QWk for 12 weeks of treatment.

DRUG

Tenofovir

Tenofovir will be administered as per local labeling.

Trial Locations (14)

112

Taipei Veterans General Hospital, Taipei

807

Kaohsiung Medical Uni Chung-Ho Memorial Hospital; Dept of Internal Medicine, Kaohsiung City

1010

Auckland Clinical Studies Limited, Grafton

3248

Waikato Hospital, Hamilton

10002

National Taiwan University Hospital, Taipei

59100

University Malaya Medical Center, Kuala Lumpur

68000

Hospital Ampang, Ampang

68100

Hospital Selayang; Medicine, Batu Caves

529889

Changi General Hospital, Singapore

Unknown

Queen Mary Hospital, Hong Kong

Prince of Wales Hospital; Special Medical Clinic, N.T.

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02391805 - A Study of Treatment With RO6864018 in Virologically Suppressed Participants With Chronic Hepatitis B Virus (HBV) Infection | Biotech Hunter | Biotech Hunter