Cough According to Stimulus Type in PD

PHASE1CompletedINTERVENTIONAL
Enrollment

158

Participants

Timeline

Start Date

April 30, 2015

Primary Completion Date

February 10, 2017

Study Completion Date

February 13, 2019

Conditions
Parkinson's Disease
Interventions
DRUG

Capsaicin vapor

Single-breath and continuous inhalation paradigm to induce cough.

OTHER

fog

Continuous inhalation of fog until a cough is produced, or up to 60 seconds (whichever is shortest)

RADIATION

Videofluoroscopic swallow evaluation

Fluoroscopic evaluation of oropharyngeal swallowing function.

DEVICE

Nebulizer

A hand-held nebulizer will be used to aerosolize the capsaicin and water solutions. Participants will inhale through the device's mouthpiece, and cough if they need to.

Trial Locations (1)

32611

University of Florida Center for Movement Disorders and Neurorestoration, Gainesville

All Listed Sponsors
collaborator

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

lead

University of Florida

OTHER

NCT02390089 - Cough According to Stimulus Type in PD | Biotech Hunter | Biotech Hunter