20,010
Participants
Start Date
May 1, 2017
Primary Completion Date
April 26, 2023
Study Completion Date
April 26, 2023
SDD Oral Paste
A six-hourly topical application of 0.5g paste, containing colistin 10mg, tobramycin 10mg and nystatin 125,000 IU, to the buccal mucosa and oropharynx
SDD Gastric Suspension
2\. A six-hourly administration of 10 mL of a suspension containing 100 mg colistin, 80 mg tobramycin and 2 x 10 \^6 IU nystatin, to the gastrointestinal tract via a gastric/post-pyloric tube
Intravenous Antibiotic
A four-day course of an intravenous antibiotic in patients not already receiving a therapeutic antibiotic
The George Institute for Global Health, Sydney
Sunnybrook Health Sciences Centre, Toronto
Imperial College London, London
Imperial College London
OTHER
Sunnybrook Health Sciences Centre
OTHER
The George Institute
OTHER