Carboplatin/Nab-Paclitaxel and Pembrolizumab in NSCLC

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

June 4, 2015

Primary Completion Date

April 14, 2022

Study Completion Date

April 14, 2022

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Carboplatin

Carboplatin AUC 6 IV, D1 for 4 cycles (cycle = 21 days)

DRUG

Nab-paclitaxel

Nab-paclitaxel 100 mg/m2 IV, D1, D8, D15 for 4 cycles (cycle = 21 days)

DRUG

MK-3475 (Phase I)

"MK-3475 2 mg/kg IV, D1 for 4 cycles (Cohort 1) or 3 cycles (Cohort 2) (cycle = 21 days)~Maintenance MK-3475 2 mg/kg IV continues every 21 days after Cycle 4 for up to 2 years."

DRUG

MK-3475 (Phase II)

"MK-3475 200 mg IV Day 1 of each cycle (cycle = 21 days)~Maintenance MK-3475 2 mg/kg IV continues every 21 days after Cycle 4 for up to 2 years."

Trial Locations (5)

22908

University of Virginia Cancer Center, Charlottesville

46202

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

46219

IU Health Central Indiana Cancer Center, Indianapolis

60611

Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago

91010

City of Hope, Duarte

All Listed Sponsors
collaborator

Hoosier Cancer Research Network

OTHER

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Celgene Corporation

INDUSTRY

lead

Nisha Mohindra, MD

OTHER