Dose-Finding Study of Afuresertib Administered in Combination With Either Enzalutamide or Aibraterone

White of off-white round immediate release tablet for oral administration with unit dose strength of 50 mg and 75 mg to achieve the dosage level of 100 mg, 125 mg, 150 mg or 200 mg once daily.

Opaque white to off-white capsule for oral administration with unit dose strength of 40mg to achieve dose level of 160 mg once daily.

White to off-white tablet for oral administration with unit dose strength 250 mg to achieve dose level of 1000 mg once daily.

Continuous twice daily co administration of prednisone 5 mg as per labelled recommendation from United State Prescribing Information.