Impact of iMRI on the Extent of Resection in Patients With Newly Diagnosed Glioblastomas

NACompletedINTERVENTIONAL
Enrollment

315

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

June 30, 2020

Study Completion Date

July 1, 2021

Conditions
Glioblastoma
Interventions
DEVICE

iMRI-guided surgery

For iMRI-guided glioma resections the surgery can be paused and a direct intraoperative resection control is possible by performing an intraoperative MRI scan. If residual tumor is found, the resection might be continued.

DRUG

5-ALA-guided surgery

For 5-ALA guided glioma resections patients have to drink 100ml of a solution with 5-Aminolevulinic acid 4-6 hours before surgery. Intraoperatively the light source of the surgical microscope can be switched to a certain wave length to enable fluorescence of the glioma cells, which helps resecting the tumor as radical as possible.

Trial Locations (15)

Unknown

Department of Neurosurgery, Universitätsklinikum Bonn, Bonn, Germany, Bonn

Department of Neurosurgery, Universität zu Köln, Köln, Germany, Cologne

Städtisches Klinikum Dresden Friedrichstadt, Dresden

Department of Neurosurgery, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Düsseldorf

Department of Neurosurgery, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen

Department of Neurosurgery, Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt a.M.

Department of Neurosurgery, Georg-August-Universität Göttingen, Göttingen,, Göttingen

Department of Neurosurgery, University of Ulm, Hospital Günzburg,, Günzburg

Asklepios Klinik Hamburg, Klinik für Neurochirurgie, Hamburg

International Neuroscience Institute Hannover, Hannover, Germany, Hanover

Department of Neurosurgery, Ruprecht-Karls-University Heidelberg, Heidelberg

Department of Neurosurgery, University of Schleswig-Holstein, Kiel, Germany, Kiel

Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany, Münster

Department of Neurosurgery, Eberhard Karls University, Tübingen,, Tübingen

Department of Neurosurgery, Julius-Maximilians-Universität Würzburg, Würzburg

All Listed Sponsors
lead

University Hospital Tuebingen

OTHER

NCT02379572 - Impact of iMRI on the Extent of Resection in Patients With Newly Diagnosed Glioblastomas | Biotech Hunter | Biotech Hunter