Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

420

Participants

Timeline

Start Date

August 6, 2015

Primary Completion Date

June 1, 2031

Study Completion Date

June 1, 2031

Conditions
Germ Cell TumorTeratomaChoriocarcinomaGerminomaMixed Germ Cell TumorYolk Sac TumorChildhood TeratomaMalignant Germ Cell NeoplasmExtragonadal SeminomaNon-seminomatous Germ Cell TumorSeminoma
Interventions
DRUG

paclitaxel

IV

DRUG

ifosfamide

IV

DRUG

cisplatin

IV

DRUG

pegylated G-CSF

IV

DRUG

G-CSF

IV

DRUG

carboplatin

IV

DRUG

etoposide phosphate

IV

PROCEDURE

stem cell reinfusion

surgical procedure

Trial Locations (125)

8

Saint James Hospital, Dublin

1070

Institut Jules Bordet, Anderlecht

1200

University Hospital Saint Luc, Brussels

1211

Hopitaux Universitaires de Geneve, Geneva

2050

Royal Prince Alfred Hospital, Camperdown

2100

Rigshospitalet University Hospital, Copenhagen

3000

Peter MacCallum Cancer Centre, Melbourne

3010

Inselspital, Bern

3128

Box Hill Hospital, Box Hill

4102

Princess Alexandra Hospital, Woolloongabba

8091

University Hospital Zurich, Zurich

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, East White Plains

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

12203

University of Berlin Charite Campus Benjamin Franklin, Berlin

13273

Institut Paoli Calmettes, Marseille

14263

Roswell Park Cancer Institute, Buffalo

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19803

Alfred I duPont Hospital for Children, Wilmington

20007

MedStar Georgetown University Hospital, Washington D.C.

20133

Istituto Nazionale Tumori, Milan

20246

University Medical Center Hamburg-Eppendorf, Hamburg

21052

Ospedale di Circolo di Busto Arsizio, Busto Arsizio

27100

San Matteo Hospital, Pavia

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

28041

Hospital Universitario 12 de Octubre, Madrid

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29425

Medical University of South Carolina, Charleston

29601

Saint Francis Hospital, Greenville

29605

BI-LO Charities Children's Cancer Center, Greenville

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29607

Saint Francis Cancer Center, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30008

Hospital General Universitario Morales Meseguer, Murcia

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

31052

Center Claudius Regaud, Toulouse

32207

Nemours Children's Clinic-Jacksonville, Jacksonville

32610

University of Florida Health Science Center - Gainesville, Gainesville

32806

Arnold Palmer Hospital for Children, Orlando

33155

Nicklaus Children's Hospital, Miami

33176

Miami Cancer Institute, Miami

33607

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

33701

Johns Hopkins All Children's Hospital, St. Petersburg

35033

Philipps University Marburg, Marburg

35233

Children's Hospital of Alabama, Birmingham

37203

The Children's Hospital at TriStar Centennial, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

38105

Saint Jude Children's Research Hospital, Memphis

40225

University of Dusseldorf, Düsseldorf

43210

Ohio State University Comprehensive Cancer Center, Columbus

45122

University of Essen, Essen

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

47014

Istituto Scientifico Romagnolo, Meldola

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

49503

Spectrum Health at Butterworth Campus, Grand Rapids

49519

University of Michigan Health - West, Wyoming

53226

Medical College of Wisconsin, Milwaukee

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54511

Centre Alexis Vautrin, Vandœuvre-lès-Nancy

54548

Marshfield Clinic-Minocqua Center, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

56068

GK-Mittelrhein Saint Martin's, Koblenz

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

63110

Washington University School of Medicine, St Louis

67091

CHRU Strasbourg - Hospital Civil, Strasbourg

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

68114

Nebraska Methodist Hospital, Omaha

69120

UniversitaetsKlinikum Heidelberg, Heidelberg

69373

Centre Leon Berard, Lyon

70121

Ochsner Medical Center Jefferson, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75970

Hopital Tenon/Assistance Publique - Hopitaux de Paris, Paris

77030

M D Anderson Cancer Center, Houston

79905

El Paso Children's Hospital, El Paso

80634

Rotkreuzklinikum Munchen, Munich

89081

University Hospital Ulm, Ulm

89144

Summerlin Hospital Medical Center, Las Vegas

90033

USC / Norris Comprehensive Cancer Center, Los Angeles

90419

Klinikum Nurnberg Nord, Nuremberg

92093

UC San Diego Moores Cancer Center, La Jolla

92354

Loma Linda University Medical Center, Loma Linda

94158

UCSF Medical Center-Mission Bay, San Francisco

94304

Stanford Cancer Institute Palo Alto, Palo Alto

94611

Kaiser Permanente-Oakland, Oakland

94805

Gustave Roussy, Villejuif

98105

Seattle Children's Hospital, Seattle

02215

Dana-Farber Cancer Institute, Boston

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07601

Hackensack University Medical Center, Hackensack

07748

Memorial Sloan Kettering Monmouth, Middletown

07503

Saint Joseph's Regional Medical Center, Paterson

02903

Rhode Island Hospital, Providence

01307

Technical University Dresden, Dresden

1066 CX

The Netherlands Cancer Institute, Amsterdam

9700 GZ

University Medical Center Groningen, Groningen

6500 HB

Radboud University Nijmegen Medical Centre, Nijmegen

08025

Hospital De La Santa Creu I Sant Pau, Barcelona

08908

Duran i Reynals Hospital-Catalan Institute of Oncology, Barcelona

EC1A 7BE

Saint Bartholomew's Hospital, London

M20 4BX

Christie Hospital, Manchester

S10 2SJ

Weston Park Hospital, Sheffield

SO16 6YD

Southampton General Hospital, Southampton

LS9 7TF

Saint James's University Hospital, West Yorkshire

G12 0YN

Beatson Oncology Center, Glasgow

NG5 1PB

Nottingham City Hospital, Nottingham

SM2 5PT

The Royal Marsden NHS Foundation Trust - Sutton, Surrey

Sponsors
All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

collaborator

Movember Foundation

OTHER

collaborator

Institute of Cancer Research (ICR), United Kingdom

UNKNOWN

collaborator

Cancer Research UK

OTHER

collaborator

UNICANCER

OTHER

collaborator

Irish Group CTI

UNKNOWN

lead

Alliance for Clinical Trials in Oncology

OTHER