192
Participants
Start Date
June 16, 2015
Primary Completion Date
August 30, 2017
Study Completion Date
January 4, 2018
Periocular triamcinolone 40 mg
Periocular triamcinolone acetonide, 40 mg injection may be given either by posterior sub-Tenon's approach or by the orbital floor approach, as both appear to have similar efficacy; the approach to the periocular injection will be recorded for analysis if needed.
Intravitreal triamcinolone 4 mg
Intravitreal triamcinolone acetonide, 4 mg injection procedures should be carried out under controlled aseptic conditions which include the use of sterile gloves and a sterile eyelid speculum (or equivalent). Adequate anesthesia and a broad-spectrum microbicide such as betadine, applied to the periocular skin, eyelid and ocular surface are required prior to an intravitreal injection.
Dexamethasone intravitreal implant
• Standard preparation as described for intravitreal injections.
New York Eye and Ear Infirmary, New York
Unniversity of Pittsburgh Medical Center, Pittsburgh
Scheie Eye Institute, University of Pennsylvania, Philadelphia
Wills Eye Hospital, Philadelphia
National Eye Institute, NIH, Bethesda
Johns Hopkins University, Baltimore
Duke Eye Center, Duke University, Durham
Emory University, Atlanta
Anne Bates Leach Eye Hospital, University of Miami Miller School of Medicine, Miami
University of South Florida, Tampa
Kellogg Eye Center, University of Michigan, Ann Arbor
University of Iowa, Iowa City
MAYO Clinic, Rochester
Northwestern University, Chicago
Rush University Medical Center, Chicago
Washington University School of Medicine, St Louis
Vitreoretinal Consultants, Houston
John A. Moran Eye Center, University of Utah, Salt Lake City
Jules Stein Eye Institute, UCLA, Los Angeles
University of California, San Francisco, San Francisco
University of Washington, Seattle
Massachusetts Eye and Ear Infirmary, Boston
Ophthalmic Consultants of Boston, Boston
Royal Victorian Eye & Ear Hospital, East Melbourne
McGill University, Montreal
Moorfields Eye Hospital, London
Lead Sponsor
National Eye Institute (NEI)
NIH
JHSPH Center for Clinical Trials
OTHER