A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase

PHASE3CompletedINTERVENTIONAL
Enrollment

512

Participants

Timeline

Start Date

October 22, 2015

Primary Completion Date

July 7, 2021

Study Completion Date

July 7, 2021

Conditions
LymphomaAcute Lymphoblastic Leukemia
Interventions
DRUG

Apixaban

OTHER

No systemic anticoagulant prophylaxis

Trial Locations (96)

1020

Local Institution, Brussels

1094

Local Institution, Budapest

1200

Local Institution, Brussels

2305

Local Institution, New Lambton Heights

2650

Local Institution, Edegem

3000

Local Institution, Leuven

3052

Local Institution, Parkville

3168

Monash Medical Centre Clayton, Clayton

4032

Local Institution, Debrecen

4101

Queensland Children's Hospital, Sth Brisbane

7623

Local Institution, Pécs

8011

Local Institution, Christchurch

9000

Local Institution, Ghent

10595

New York Medical College, Valhalla

12208

Albany Medical Center, Albany

13210

SUNY Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14642

University Of Rochester General Clinical Research Center, Rochester

15224

Children's Hospital Of Pittsburgh Of UPMC, Pittsburgh

17033

Penn State Hershey Medical Center, Hershey

17822

Geisinger Medical Center, Danville

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

19104

Childrens Hospital Of Philadelphia, Philadelphia

19803

Nemours / A. I. duPont Hospital for Children, Wilmington

21215

Sinai Hospital Of Baltimore, Baltimore

21287

Johns Hopkins University, Baltimore

27157

Wake Forest Baptist Health, Winston-Salem

27599

Unv. Of Nc At Chapel Hill, Chapel Hill

30342

Childrens Healthcare Of Atlanta - E, Atlanta

31201

Navicent Health Physician Group, Macon

32207

Nemours Children'S Clinic, Jacksonville

32504

Nemours Children'S Clinic-Pensacola, Pensacola

32827

Nemours Children'S Clinic - Orlando, Orlando

33407

St. Marys Medical Center, West Palm Beach

33701

All Childrens Hospital Specialty Physicians, St. Petersburg

33908

Golisano Childrens Hospital of Southwest Florida, Fort Myers

37203

Children's Hospital at TriStar Centennial, Nashville

37232

Monroe Carell Jr Children'S Hosp. At Vanderbilt Tower, Nashville

39216

University Of Mississippi Medical Center, Jackson

40202

University Of Louisville, Louisville

43205

Nationwide Children'S Hospital, Columbus

44106

University Hospitals, Cleveland

44308

Akron Children'S Hospital, Akron

44340

Local Institution, Guadalajara

46260

Children'S Center For Cancer And Blood Diseases, Indianapolis

48109

University Of Michigan Cancer Center, Ann Arbor

50309

Blank Childrens Hospital, Des Moines

52242

University of Iowa Hospitals and Clinics, Iowa City

53226

Medical College of Wisconsin, Milwaukee

55404

Childrens Hospitals And Clinics Of Minnesota, Minneapolis

55455

University Of Minnesota, Minneapolis

55905

Mayo Clinic Rochester, Rochester

64460

Local Institution, Monterrey

70118

Childrens Hospital New Orleans, New Orleans

70121

Ochsner Medical Center, New Orleans

76502

Scott & White - McLane Children's Specialty Clinic, Temple

77030

Texas Children's Cancer and Hematology Centers, Houston

78207

Children's Hospital of San Antonio, San Antonio

78284

University Hospital, San Antonio

78411

Driscoll Children'S Hospital, Corpus Christi

78723

Dell Children'S Medical Center Of Central Texas, Austin

83712

St. Luke'S Mountain State Tumor Institute, Boise

85016

Phoenix Children'S Hospital/Ctr. For Cancer & Blood Ctr., Phoenix

90027

Childrens Hospital Of La, Los Angeles

91010

City of Hope, Duarte

92350

Loma Linda University Cancer Center, Loma Linda

92868

Children'S Hospital Of Orange County, Orange

94304

Lucile Packard Children's Hospital (LPCH), Palo Alto

98405

MultiCare Institute for Research & Innovation, Tacoma

99204

Providence Sacred Heart Medical Center, Spokane

115478

Local Institution, Moscow

117198

Local Institution, Moscow

197341

Local Institution, Saint Petersburg

197758

Local Institution, Saint Petersburg

610027

Local Institution, Kirov

92123-4282

Rady Children'S Hospital - San Diego, San Diego

06106

Connecticut Children's Medical Center, Hartford

06520

Yale University School Of Medicine, New Haven

32610-0298

Shands Hospital At University Of Florida, Gainesville

40536-0293

University of Kentucky, Lexington

07601

Hackensack University Medical Center, Hackensack

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

07503

Valerie Fund Children's Center at St. Joseph's Children's Hospital, Paterson

45229-3039

Cincinnati Children'S Hospital Medical Center, Cincinnati

T3B 6A8

Alberta Children'S Hospital, Calgary

T6G 2B7

Local Institution, Edmonton

A1B 3V6

Local Institution, St. John's

N6A 5W9

Children'S Hospital London Health Sciences Centre, London

K1H 8L1

Children'S Hospital Of Eastern Ontario, Ottawa

613 00

Klinika detske onkologie, Brno

04530

Local Institution, Df

50-556

Klinika Transplantacji Szpiku Onkologii i Hematologii Dzieciecej, Wroclaw

41-800

Oddzial Hematologii i Onkologii Dzieciecej, Zabrze

00725

Local Institution, Caguas

03080

Local Institution, Seoul

03722

Local Institution, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY